Abstract：
:Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative condition of the central nervous system that preferentially afflicts women more than men. Low estrogen states such as menopause and the postpartum period favor exacerbations of multiple sclerosis in women with the disease. Existing and emerging evidence suggests a role for estrogen in the alleviation of symptoms and reversal of pathology associated with MS. While clinical evidence is sparse regarding the benefit of estrogen therapy for women at risk for MS exacerbations, scientific data demonstrates that estrogen potentiates numerous neuroprotective effects on the central nervous system (CNS). Estrogens play a wide range of roles involved in MS disease pathophysiology, including increasing antiinflammatory cytokines, decreasing demyelination, and enhancing oxidative and energy producing processes in CNS cells.
journal_name
Maturitasjournal_title
Maturitasauthors
Christianson MS,Mensah VA,Shen Wdoi
10.1016/j.maturitas.2014.11.013subject
Has Abstractpub_date
2015-02-01 00:00:00pages
133-9issue
2eissn
0378-5122issn
1873-4111pii
S0378-5122(14)00366-1journal_volume
80pub_type
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