Abstract：
OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential therapy, while the remaining 51 women were given placebo for 2 years with no subsequent therapy. After 2 years of the trial, the women were followed in an open investigation for a total of 8 years. RESULTS:After 8 years, 112 (85%) women were interviewed. None of the women in the combined group had changed to other therapies (46% were still in treatment), 32% were still being treated with sequential therapy and 18% had changed to other HRTs (mainly because the women disliked the monthly bleeding induced). Of the placebo group, 18% had started HRT while 53% still did not receive any therapy. Of the women who had taken combined therapy for 5 years, 95% were still in therapy at the 8-year stage. Of the 25 women who had taken sequential therapy for 5 years, 52% continued until the 8-year stage and a further 16% received other types of HRT. The women who changed HRT switched to continuous combined therapy. CONCLUSION:The continuous combined treatment might provide an alternative to sequential treatment in postmenopausal women to achieve high long-term compliance.
journal_name
Maturitasjournal_title
Maturitasauthors
Eiken P,Kolthoff Ndoi
10.1016/0378-5122(95)00921-7subject
Has Abstractpub_date
1995-09-01 00:00:00pages
97-103issue
2eissn
0378-5122issn
1873-4111pii
0378-5122(95)00921-7journal_volume
22pub_type
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