Abstract:
OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and their relationship to bone mineral density. METHODS:The PTH secretion test was performed by induction of hypocalcemia through intravenous administration of EDTA for 2h. Blood samples were collected every 10 min and used for ionic calcium and PTH measurements. During the basal period, an additional sample was collected for the determination of osteocalcin, FSH, and estradiol. A sample of early morning second voided urine was collected for analysis of deoxypiridinoline and creatinine as well as bone mass density (BMD) was determined by dual X-ray energy absorptiometry (DEXA). RESULTS:The aged patients presented lower femoral BMD (Y=0.860 g/cm(2) vs. M=0.690 g/cm(2), p<0.01), with four of them having a T score lower than -2.5 S.D. Basal, and during the EDTA infusion, PTH values were similar in both groups. However, among aged volunteers, the rise in PTH levels was higher for subjects with normal bone mass (NM: peak=236 pg/ml) than for subjects with osteoporosis (OM: peak=134.4 pg/ml). CONCLUSIONS:The present results suggest that PTH can have a modulating effect on the rate of bone loss during late menopause.
journal_name
Maturitasjournal_title
Maturitasauthors
Pereira LC,Pereira FA,Sá MF,Foss MC,de Paula FJdoi
10.1016/j.maturitas.2007.10.002subject
Has Abstractpub_date
2008-01-20 00:00:00pages
91-4issue
1eissn
0378-5122issn
1873-4111pii
S0378-5122(07)00293-9journal_volume
59pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(00)00159-6
更新日期:2000-11-30 00:00:00
abstract::Heart disease is a major cause of death, disease and disability in the developed world for both men and women. Women appear to be under-diagnosed and treated both because they fail to visit the doctor or hospital with relevant symptoms and because doctors tend to dismiss the seriousness of women's symptoms of heart di...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.11.019
更新日期:2010-03-01 00:00:00
abstract::Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(94)90100-7
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.01.013
更新日期:2006-09-20 00:00:00
abstract::Population health outcomes are shaped by complex interactions between individuals and the environments in which they live, work and play. Environments encompass streets and buildings (physical environment), attitudes, supports and relationships with others (social environment), as well as social and political systems ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.07.011
更新日期:2009-09-20 00:00:00
abstract:OBJECTIVE:To examine whether physical activity during the last five years is related to later breast mammographic density in postmenopausal Greek women. METHODS:We designed a cross-sectional study in 724 women, of ages 45-67 years. An interview-administered questionnaire was used to obtain information on duration and ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2011.02.003
更新日期:2011-05-01 00:00:00
abstract::The aim of this trial was to study the vaginal absorption of oestriol and to investigate whether morning rather than evening oestriol administration would produce different plasma oestriol patterns. The influence of food intake on plasma oestriol levels was also investigated. Nine post-menopausal women were given 0.5 ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(86)90031-9
更新日期:1986-10-01 00:00:00
abstract:OBJECTIVES:Frailty and cognitive impairment in late life increase the risk of mortality. Physical frailty is closely associated with cognitive impairment. The aim of the study was to examine the independent and interaction effects of frailty and cognitive impairment in predicting mortality. STUDY DESIGN:A nationally r...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.10.006
更新日期:2018-01-01 00:00:00
abstract::Earlier menopause onset has been linked to a greater risk of cardiovascular disease. Both menopause onset and cardiovascular disease risk vary by geographical region, race/ethnicity and socioeconomic status. As such, it is plausible to hypothesize that these factors may influence the association of menopause onset and...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2020.06.007
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To clarify the effect of programmed exercise (PE), performed for at least six weeks, on perceived stress (PS) in middle aged and old women. METHODS:A structured search was carried out in PubMed, Embase, Cochrane Library, Scielo, Web of Science and Scopus, from database inception through January 10, 2018, wit...
journal_title:Maturitas
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.maturitas.2018.05.004
更新日期:2018-08-01 00:00:00
abstract::Forty-five healthy postmenopausal women participated in a study designed to examine the effects on bone and mineral metabolism of SHD 386L, a new hormone replacement therapy (HRT) regime. This oral preparation delivers 2 mg estradiol valerate daily and 75 micrograms of levonorgestrel from days 17-28 inclusive of a 28-...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(92)90114-j
更新日期:1992-03-01 00:00:00
abstract::This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly mens...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(93)90120-7
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA1/2 families from the northern Netherlands. STUDY DESIGN:A consecutive series of 1763 mutation car...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.07.001
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. STUDY DESIGN:This was a single-blind randomi...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2019.10.014
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Traditionally, general practitioners (GPs) are not involved in cancer-related treatment decisions, despite their often long relationship with patients, and their unique position to explore patients' values, especially with older patients. Therefore, we designed a randomised controlled trial to study the effect,...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2016.11.014
更新日期:2017-02-01 00:00:00
abstract::Serum cholesterol concentrations in lipoprotein fractions and subfractions were determined in 11 peri-menopausal women both before and after bilateral oophorectomy, as well as 60 days after commencement of oral oestradiol replacement therapy. Pre-operatively, all subjects were found to have normal lipid and lipoprotei...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(83)90002-6
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVES:Bone mineral density (BMD) and development of osteoporosis are partly determined by genetic factors. The associations between one of suggested candidate, apolipoprotein E (apo E) genotype to bone mineral density (BMD) and bone biochemical markers was studied in 464 subjects recruited from a population-based ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00084-5
更新日期:2000-01-15 00:00:00
abstract::Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and end...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(84)90065-3
更新日期:1984-07-01 00:00:00
abstract::In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00010-5
更新日期:2002-04-15 00:00:00
abstract::The effect of two forms of exogenous estrogen and a placebo on diastolic blood pressure and bodyweight was evaluated in 50 oophorectomized women. There was no significant change in bodyweight on any form of treatment, nor was there any significant elevation in mean diastolic blood pressure. However, 2 out of 49 female...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(78)90003-8
更新日期:1978-06-01 00:00:00
abstract:OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00259-6
更新日期:2002-02-26 00:00:00
abstract:BACKGROUND:Several studies drawn from the Ecuadorian population have previously reported that more than half of mid-aged women present hot flushes, which can impair their quality of life. However up-to-date risk factors for their presence and severity have not been assessed. OBJECTIVE:To assess hot flush frequency and...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.11.024
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:Evaluate the association of self-reported vasomotor symptom (VMS) frequency with race/ethnicity among a diverse midlife US population and explore menopause symptom differences by dietary soy isoflavone (genistein+daidzein) consumption. STUDY DESIGN:Cross-sectional population-based study of peri- and postmen...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.03.003
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the prevalence of depressive symptoms in peri- and post-menopausal Taiwanese women, and to investigate the relation between depressive symptoms and demographic variables, chronic disease status, health habits, stress management, menopausal symptoms, and attitudes towa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.04.021
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(95)00983-3
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant furth...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00302-4
更新日期:2002-05-20 00:00:00
abstract:INTRODUCTION:Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. METHODS:A prospective randomized...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2013.06.016
更新日期:2013-10-01 00:00:00
abstract::Health care focuses on controlling symptoms and managing risk factors to improve survival by avoiding future complications. Diagnoses describe a group of signs and symptoms, often implying specific aetiologies and underlying pathophysiological disease processes. The diagnosis provides a tool for the health professiona...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2019.02.010
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Decision-making during menopause (especially surgical menopause) can be complex given the variability in risk-benefit perceptions of menopausal treatments. Decision aid tools (DATs) help women participate in decision-making about options. Our objective is to identify and evaluate the content and development o...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2017.09.006
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:We aimed to prospectively examine the relationship between vision and hearing loss and successful aging in a cohort of older adults. STUDY DESIGN:We analyzed 5-year data (1997-9 to 2002-4) from 1,085 adults aged 55+ years, who were free of cancer, coronary artery disease and stroke at baseline and who had co...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.10.015
更新日期:2021-01-01 00:00:00