Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.


BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY DESIGN:Postmenopausal women were studied by an open randomised study during 9 months. Subjects were recruited from outpatient clinics in a rural area of Sweden. Major inclusive criteria comprised body mass index (BMI) >28, serum triglycerides >1.5 mmol/l. Participants were at least 12 months postmenopause with a concomitant serum Follicle Stimulating Hormone (FSH) above 28 IU/l. After inclusion in the study patients were instructed to adhere to a low-fat and caloric diet for 3 months and after this period randomised into two groups of intervention; a lipidlowering fibrate (LLF) group and one hormone replacement therapy group (HRT). The LLF group was given gemfibrozil 600 mg orally twice daily and HRT group received 2 mg oestradiol in combination with 1 mg norethisterone acetate as a continuous combined therapy once daily. After 3 months, the LLF group added the HRT regimen and patients in the HRT group added gemfibrozil. Hence, all participants received the regimens combined for the last 6 months of the study. RESULTS:Serum s-cholesterol was markedly decreased in both groups during the first 3 months of single treatment (P<0.0001). This decrease reflected a reduction especially of calculated low density lipoprotein (LDL) s-cholesterol (P<0.001). High density lipoprotein (HDL) s-cholesterol was reduced in the HRT group (P<0.005) but increased (P<0.004) in the LLF group. Triglycerides were also decreased by both treatments but more marked in the LLF group (P<0.0001) than in the HRT group (P<0.02). After 9 months the reduction remained in both groups but no additive effects were encountered in any of the groups. CONCLUSION:The effects by gemfibrozil on s-cholesterol and triglycerides levels seem to be superior to continuous combined HRT in overweight women with elevated triglycerides. The combination of the two drugs did not seem to offer any additional benefit concerning the routine serum lipid or lipoprotein profile.






Nerbrand C,Nyberg P,Nordström L,Samsioe G





Has Abstract


2002-05-20 00:00:00














  • Predictive ability and reliability of the STOP-BANG questionnaire in screening for obstructive sleep apnea in midlife women.

    abstract:OBJECTIVES:The STOP-BANG questionnaire (snoring, tiredness, observed apneas, high blood pressure, body mass index, age, neck size, gender) was originally validated to screen for obstructive sleep apnea (OSA) in the surgical population. It has been validated in mixed populations of men and women. We aimed to evaluate it...


    pub_type: 杂志文章


    authors: Orbea CAP,Lloyd RM,Faubion SS,Miller VM,Mara KC,Kapoor E

    更新日期:2020-05-01 00:00:00

  • Sitting time increases the overweight and obesity risk independently of walking time in elderly people from Spain.

    abstract:INTRODUCTION:Obesity, defined as an excess of total body fat, is a matter of concern all over the world, and its prevalence is still increasing among elderly people. OBJECTIVES:To examine whether sedentary behaviour (hours sitting per day) is associated with higher risk of central obesity, overweight-obesity and overf...


    pub_type: 杂志文章


    authors: Gómez-Cabello A,Pedrero-Chamizo R,Olivares PR,Hernández-Perera R,Rodríguez-Marroyo JA,Mata E,Aznar S,Villa JG,Espino-Torón L,Gusi N,González-Gross M,Casajús JA,Ara I,Vicente-Rodríguez G,EXERNET Study Group.

    更新日期:2012-12-01 00:00:00

  • Progestins in HRT: sufferance or desire?

    abstract::While the benefits of progestins in hormonal replacement therapy are well recognized as far as endometrial protection is concerned the data on breast tissue and the cardiovascular system are contentious. Following the Women's Health Initiative study, the Million Women Study and The Women's International Study of Long-...


    pub_type: 杂志文章,评审


    authors: Skouby SO,Jespersen J

    更新日期:2009-04-20 00:00:00

  • Neuropsychiatric aspects of dementia.

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    pub_type: 杂志文章,评审


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    更新日期:2014-10-01 00:00:00

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    abstract::A review of how the anthropologist has studied the menopause, the climacteric and middle age is given. The types of field methodology used by the anthropologist in the above-mentioned studies are described, and their application for research in other fields is suggested. Research problems which have yet to be addresse...


    pub_type: 杂志文章


    authors: Flint M

    更新日期:1982-11-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Tax L,Goorissen EM,Kicovic PM

    更新日期:1987-01-01 00:00:00

  • Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women.

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    pub_type: 杂志文章


    authors: Iki M,Kajita E,Dohi Y,Nishino H,Kusaka Y,Tsuchida C,Yamamoto K,Ishii Y

    更新日期:1996-08-01 00:00:00

  • Screening for women with increased risk of fragility fractures in a general female population using digital X-ray radiogrammetry (DXR).

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    authors: Wilczek ML,Bhatta L,Brumpton BM,Freyschuss B,Brismar TB

    更新日期:2021-02-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Wildemeersch D,Janssens D,Pylyser K,De Wever N,Verbeeck G,Dhont M,Tjalma W

    更新日期:2007-06-20 00:00:00

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    pub_type: 杂志文章


    authors: Gambrell RD Jr

    更新日期:1986-07-01 00:00:00

  • Menopausal symptoms and symptom clustering in Chinese women.

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    authors: Ho SC,Chan SG,Yip YB,Cheng A,Yi Q,Chan C

    更新日期:1999-12-15 00:00:00

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    authors: Dam AE,de Vugt ME,Klinkenberg IP,Verhey FR,van Boxtel MP

    更新日期:2016-03-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Rapuri PB,Gallagher JC,Knezetic JA,Haynatzka V

    更新日期:2006-03-20 00:00:00

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    authors: Stamatelopoulos K,Papavagelis C,Augoulea A,Armeni E,Karagkouni I,Avgeraki E,Georgiopoulos G,Yannakoulia M,Lambrinoudaki I

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bottiglione F,Volpe A,Esposito G,Aloysio DD

    更新日期:1995-11-01 00:00:00

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    authors: Berstein L,Zimarina T,Imyanitov E,Kovalevskij A,Maximov S,Pujol P,Thijssen J

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    abstract::From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...


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    authors: McCoy NL,Davidson JM

    更新日期:1985-09-01 00:00:00

  • Association between physical inactivity and health-related quality of life in adults with coronary heart disease.

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    abstract:OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...


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    authors: Tikkanen MJ

    更新日期:1996-05-01 00:00:00

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    abstract::It is important for our aging population to remain active, particularly those with chronic diseases, like Parkinson disease (PD), which limit mobility. Recent studies in older adults and people with PD suggest dance interventions provide various motor benefits. The literature for dance in PD is growing, but many knowl...


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    authors: McNeely ME,Duncan RP,Earhart GM

    更新日期:2015-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Heimer GM,Englund DE

    更新日期:1986-10-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    authors: Cugini P,Scavo D,Halberg F,Sothern RB,Cornelissen G,Meucci T,Salandi E,Massimiani F

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    authors: van der Mooren MJ,Hanselaar AG,Borm GF,Rolland R

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    pub_type: 杂志文章


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