Abstract:
BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY DESIGN:Postmenopausal women were studied by an open randomised study during 9 months. Subjects were recruited from outpatient clinics in a rural area of Sweden. Major inclusive criteria comprised body mass index (BMI) >28, serum triglycerides >1.5 mmol/l. Participants were at least 12 months postmenopause with a concomitant serum Follicle Stimulating Hormone (FSH) above 28 IU/l. After inclusion in the study patients were instructed to adhere to a low-fat and caloric diet for 3 months and after this period randomised into two groups of intervention; a lipidlowering fibrate (LLF) group and one hormone replacement therapy group (HRT). The LLF group was given gemfibrozil 600 mg orally twice daily and HRT group received 2 mg oestradiol in combination with 1 mg norethisterone acetate as a continuous combined therapy once daily. After 3 months, the LLF group added the HRT regimen and patients in the HRT group added gemfibrozil. Hence, all participants received the regimens combined for the last 6 months of the study. RESULTS:Serum s-cholesterol was markedly decreased in both groups during the first 3 months of single treatment (P<0.0001). This decrease reflected a reduction especially of calculated low density lipoprotein (LDL) s-cholesterol (P<0.001). High density lipoprotein (HDL) s-cholesterol was reduced in the HRT group (P<0.005) but increased (P<0.004) in the LLF group. Triglycerides were also decreased by both treatments but more marked in the LLF group (P<0.0001) than in the HRT group (P<0.02). After 9 months the reduction remained in both groups but no additive effects were encountered in any of the groups. CONCLUSION:The effects by gemfibrozil on s-cholesterol and triglycerides levels seem to be superior to continuous combined HRT in overweight women with elevated triglycerides. The combination of the two drugs did not seem to offer any additional benefit concerning the routine serum lipid or lipoprotein profile.
journal_name
Maturitasjournal_title
Maturitasauthors
Nerbrand C,Nyberg P,Nordström L,Samsioe Gdoi
10.1016/s0378-5122(01)00302-4keywords:
subject
Has Abstractpub_date
2002-05-20 00:00:00pages
55-62issue
1eissn
0378-5122issn
1873-4111pii
S0378512201003024journal_volume
42pub_type
临床试验,杂志文章,随机对照试验相关文献
MATURITAS文献大全abstract::Vitamin D is a hormone that controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D synthesis is a process in which the skin, liver, and kidney are sequentially involved. The vitamin D pool is completed by the amount taken with food and supplements. Vitamin D deficiency causes osteopeni...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2007.05.002
更新日期:2007-10-20 00:00:00
abstract::The identification of early biochemical predictors of osteoarthritis (OA) has been the focus of much research over the past few years. However, it still is unclear whether current biochemical markers can be used in prognostic risk assessment of OA. The aim of this systematic review is to evaluate the possible prognost...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.04.004
更新日期:2015-09-01 00:00:00
abstract::Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the as...
journal_title:Maturitas
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.maturitas.2018.03.004
更新日期:2018-06-01 00:00:00
abstract::The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.10.008
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Decision-making during menopause (especially surgical menopause) can be complex given the variability in risk-benefit perceptions of menopausal treatments. Decision aid tools (DATs) help women participate in decision-making about options. Our objective is to identify and evaluate the content and development o...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2017.09.006
更新日期:2017-12-01 00:00:00
abstract::The two most important risk factors for maintaining skeletal health are the bone mass obtained at skeletal maturity (peak bone mass) and the subsequent bone loss. Those women with a low peak bone mass and a rapid bone loss are thus at increased risk of developing osteoporosis in the future, and should be identified. T...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(90)90006-r
更新日期:1990-09-01 00:00:00
abstract::It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.03.027
更新日期:2010-08-01 00:00:00
abstract::Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(87)90045-4
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVES:To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. RESULTS AND CONCLUSIONS:Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascu...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(01)00270-5
更新日期:2001-10-31 00:00:00
abstract::Menopause marks a time of dramatic hormonal and often social change for women. Both risk factors and health needs are likely to change as women pass through menopause. This paper examines the demographic characteristics of the world population of menopausal and post-menopausal women, and also examines the implication ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(95)00968-x
更新日期:1996-03-01 00:00:00
abstract::While low back pain significantly impacts on an individual's well-being, our understanding of the role of well-being in the natural history of low back pain is limited. This cohort study aimed to investigate the association between psychological and general well-being and the development and progression of low back pa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.04.007
更新日期:2018-07-01 00:00:00
abstract::Cardiovascular disease is the leading determinant of mortality and morbidity in women. Functional foods are attracting interest as potential regulators of the susceptibility to disease. Supported by epidemiological evidence, chocolate has emerged as a possible modulator of cardiovascular risk. Chocolate, or cocoa as t...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.05.011
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:The effects of supplemental testosterone on cognition, mood and wellbeing in ageing men are unclear. This study aimed to assess the effect of 12-months of oral testosterone supplementation on cognitive function, mood and quality of life in elderly men with low-normal gonadal status, not specifically selected...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2004.05.002
更新日期:2005-02-14 00:00:00
abstract::A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch appli...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(91)90098-b
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVES:Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype's trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.03.002
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate whether a previous fracture is a risk factor for fracture later in life and its association with tobacco smoking, menopausal age and the use of oral contraceptives. This is an epidemiological population study based on a questionnaire. A sample of 10000 women from ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(95)01024-6
更新日期:1996-05-01 00:00:00
abstract::From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 1...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2008.09.010
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(99)00056-0
更新日期:1999-12-15 00:00:00
abstract::The Dallas Heart Study dataset was used to examine relationships between menopausal symptoms and depressive symptom severity in 384 women (37-73 years old) self-reporting as menopausal. Self-reported menopausal symptoms were grouped based on the Menopause-specific Quality of Life Questionnaire (MENQOL). Depressive sym...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.09.009
更新日期:2021-01-01 00:00:00
abstract::Menopause is a time of anatomic, physiological and psychological changes that often influence in the sexuality of aging female. Being sexual functioning an important aspect of health and well-being, doctors should have an holistic approach reassuring about the possibility of treating the various symptoms. The central ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(02)00150-0
更新日期:2002-08-30 00:00:00
abstract:OBJECTIVE:To determine the association between relationship distress and menopausal symptoms. STUDY DESIGN:A retrospective analysis was conducted of questionnaires completed by women 40-65 years of age seeking menopause or sexual health consultation between May, 2015 and May, 2017. MAIN OUTCOME MEASURES:Associations ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2019.09.006
更新日期:2019-12-01 00:00:00
abstract::Serum oestrone, oestradiol and oestriol concentrations were investigated during oral treatment with oestradiol valerate and oestriol succinate in ovariectomized women. The dosages used were 1 mg oestradiol valerate in the morning and 2 mg oestriol succinate in the evening of the first day and 2 mg oestradiol valerate ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(78)90014-2
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVES:Cryostorage of ovarian cortical tissue, before devastating chemo- and/or radiotherapy for cancer, permits survival of primordial and early preantral follicles. This work aims for a system allowing the long-term maturation in vitro (IVM) of small immature oocytes up to fertilisable metaphase II oocytes. METH...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(98)00071-1
更新日期:1998-10-12 00:00:00
abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(81)90003-7
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.10.002
更新日期:2008-01-20 00:00:00
abstract::Sera were sampled from 83 people (pre- and post-menopausal women and men). Climacteric symptoms of 23 women were treated with conjugated estrogen. Sera were sampled serially until the 21st day of estrogen administration. Serum concentrations of 40 protein components were measured by micro single radial immunodiffusion...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(91)90282-u
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVES:The study purpose was to evaluate the longitudinal effects, after 3 months and 1-year, of a perimenopausal health education intervention for mid-life women in Taiwan. METHODS:This study was conducted at two hospitals and their neighborhood communities (each included three subgroups, traditional Chinese, gyn...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2007.01.013
更新日期:2007-07-20 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS:In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die ...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2005.02.010
更新日期:2006-01-10 00:00:00
abstract:OBJECTIVE:Ovarian cancer screening (OCS) for BRCA1/2 mutation carriers was stopped in our family cancer clinic in 2009 because of its ineffectiveness. The study objective was to investigate the effect of stopping OCS on the timing and uptake of risk-reducing salpingo-oophorectomy (RRSO) and on the percentage of occult ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.12.009
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00138-9
更新日期:2000-08-31 00:00:00