Abstract:
:The aim of this trial was to study the vaginal absorption of oestriol and to investigate whether morning rather than evening oestriol administration would produce different plasma oestriol patterns. The influence of food intake on plasma oestriol levels was also investigated. Nine post-menopausal women were given 0.5 mg oestriol (ovula supplied by Leo AB, Sweden) intravaginally every evening for 16 days. Thereafter, 1 mg oestriol was given every evening for another 5 days, except on treatment days 18 and 19 when 1 mg oestriol was given in the morning instead. Venous blood samples were collected at frequent intervals on day 19 (morning administration) and a meal was allowed 4 h later. On the day 21 (evening administration), venous blood samples were taken at frequent intervals during the night and no meal was given until the next morning. Plasma concentrations of unconjugated oestriol were measured by means of a specific radioimmunoassay (RIA). A difference was seen in the plasma oestriol patterns when the results following morning and evening administration were compared. However, no significant difference as regards the total 24-h systemic availability of oestriol was observed. A minimal increase in plasma oestriol levels was seen after a meal in the case of both morning and evening intravaginal oestriol administration, possibly as a result of enterohepatic recirculation.
journal_name
Maturitasjournal_title
Maturitasauthors
Heimer GM,Englund DEdoi
10.1016/0378-5122(86)90031-9subject
Has Abstractpub_date
1986-10-01 00:00:00pages
239-43issue
3eissn
0378-5122issn
1873-4111pii
0378-5122(86)90031-9journal_volume
8pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVES:Menopausal status is a common covariate in epidemiologic studies. Still, there are no standard definitions for menopausal status using observational data. This study assesses distinctions between menopausal status definitions using commonly collected epidemiologic data, and explores their impact on study out...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.04.015
更新日期:2010-09-01 00:00:00
abstract::Urogenital symptoms associated with estrogen loss can occur episodically throughout a woman's life (e.g. during lactation, during treatment with GnRH agonists, etc.) but it is most common and chronic in duration in postmenopausal women. More than 50% of postmenopausal women experience lack of vaginal lubrication and f...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(95)00956-6
更新日期:1995-12-01 00:00:00
abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.08.006
更新日期:2012-12-01 00:00:00
abstract::With ageing populations a major challenge is to maintain physical and cognitive function, quality of life and independence. The literature does not only indicate important gender differences in lifestyle behaviours, but also how these behaviours might affect health outcomes. The current review has a male perspective w...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2013.02.011
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:The STOP-BANG questionnaire (snoring, tiredness, observed apneas, high blood pressure, body mass index, age, neck size, gender) was originally validated to screen for obstructive sleep apnea (OSA) in the surgical population. It has been validated in mixed populations of men and women. We aimed to evaluate it...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.02.004
更新日期:2020-05-01 00:00:00
abstract::Five men and 8 women, 60-69 yr of age, and 4 men and 5 women, 17-37 yr of age, volunteered for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics of radioimmunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from r...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(81)90009-8
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVES:Qualitative studies show that women link menopause to the ageing process, and yet surprisingly little research has investigated how attitudes to ageing might shape women's experience of menopause, as well as their overall well-being at midlife. This study validated the Attitudes to Ageing Questionnaire (AAQ)...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.06.042
更新日期:2015-10-01 00:00:00
abstract::Population health outcomes are shaped by complex interactions between individuals and the environments in which they live, work and play. Environments encompass streets and buildings (physical environment), attitudes, supports and relationships with others (social environment), as well as social and political systems ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.07.011
更新日期:2009-09-20 00:00:00
abstract::End-of-life (EoL) care1 is increasingly used as a generic term in preference to palliative care or terminal care, particularly with reference to individuals with chronic disease, who are resident in community and long-term care (LTC) settings. This review evaluates studies based on patient reported outcome measures (P...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.11.004
更新日期:2017-02-01 00:00:00
abstract::A review of how the anthropologist has studied the menopause, the climacteric and middle age is given. The types of field methodology used by the anthropologist in the above-mentioned studies are described, and their application for research in other fields is suggested. Research problems which have yet to be addresse...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(82)90047-0
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.02.261
更新日期:2015-05-01 00:00:00
abstract::Two case reports of women treated with an individual cognitive behavioral treatment (CBT) for menopausal hot flashes are presented. Both women reported substantial improvements in the number of hot flashes experienced as well as in their quality of life as measured by the Menopause Quality of Life Scale (MENQOL), the ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.12.006
更新日期:2006-04-20 00:00:00
abstract:OBJECTIVE:To assess the risk of onset of menopausal symptoms at different periods surrounding menopause, and variations in this risk according to age at menopause and type of menopause. METHODS:We analyzed the 27,897 women participating in the French E3N cohort study who reached menopause during a 10-year follow-up pe...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.09.012
更新日期:2007-12-20 00:00:00
abstract::To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00111-0
更新日期:2000-05-29 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the putative changes in serum angiotensinase activities (aminopeptidase N, APN; aminopeptidase B, APB; aminopeptidase A, APA; aspartyl aminopeptidase, ASAP) involved in the renin-angiotensin system (RAS) in women with breast cancer treated or not with a neoadjuvant thera...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.02.007
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:To date, no worldwide studies have been conducted to estimate the biological age of five organs using clinical biomarkers that are associated with the aging status. Therefore, we conducted this study to develop the models for estimating the biological age of five organs (heart, lung, liver, pancreas, and kid...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.04.008
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:The effects of supplemental testosterone on cognition, mood and wellbeing in ageing men are unclear. This study aimed to assess the effect of 12-months of oral testosterone supplementation on cognitive function, mood and quality of life in elderly men with low-normal gonadal status, not specifically selected...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2004.05.002
更新日期:2005-02-14 00:00:00
abstract:OBJECTIVE:To compare the effects of (i) continuous low dosage C-19 progestin (dl-norgestrel, NG) plus cyclical conjugated estrogen (CEE) versus (ii) continuous low dosage C-21 progestin [medroxyprogesterone acetate (MPA)] plus CEE on postmenopausal vaginal bleeding, mood and somatic, psychosomatic and psychological sym...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00053-5
更新日期:1999-10-24 00:00:00
abstract::Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossibl...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(99)00069-9
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of hormone replacement therapy (HT) use by postmenopausal women doctors and doctors' wives in Italy and to explore the relationship between their personal characteristics and HT use. DESIGN:A total of 500 women doctors and 500 men doctors answering on behalf of their female partner...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.10.008
更新日期:2006-05-20 00:00:00
abstract:OBJECTIVES:25-hydroxyvitamin D [25(OH)D] deficiency is related to an increase in cardiovascular risk but the association between low 25(OH)D and hospitalization and mortality in heart failure (HF) patients remains unclear. The objective of this study was therefore to determine whether 25(OH)D deficiency is associated w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2019.11.005
更新日期:2020-02-01 00:00:00
abstract::Estrogen is a well-known mitogen in human breast epithelium but the action of progestogen is complex and incompletely understood. During the last years, accumulating data from animal, clinical and observational studies suggest a proliferative effect in breast tissue when progestogen is added to estrogen. Findings in s...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2004.06.008
更新日期:2004-09-24 00:00:00
abstract:UNLABELLED:Social engagement provides dynamic stimulation for older individuals that influences cognition. Grandparenting is an increasingly popular form of childcare that provides social activity for older adults. OBJECTIVE:To investigate the relationship between grandparenting, as a form of social engagement, and co...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.03.013
更新日期:2015-06-01 00:00:00
abstract::The increased risk of breast cancer recently observed with some specific estro-progestin associations has raised concerns about the harmful effects of menopausal hormone replacement therapy (HRT). It has been proposed that phytoestrogens (PEs), which have a similar chemical structure to estrogens, could be used as HRT...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.07.001
更新日期:2011-11-01 00:00:00
abstract::Associations between depression and impaired functioning are well known and have been documented in numerous clinical, primary care and epidemiological studies. Reviews of this research have focused on the elderly. Recent studies suggest that women become increasingly vulnerable during the menopausal transition to dec...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.09.017
更新日期:2009-11-20 00:00:00
abstract::S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0378-5122(00)00175-4
更新日期:2001-01-31 00:00:00
abstract::Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(87)90045-4
更新日期:1987-04-01 00:00:00
abstract:INTRODUCTION:The use of menopausal hormone therapy (MHT) has decreased in many countries in the past 10 years. This is a consequence of the initial publication of the results of the Women's Health Initiative (WHI) randomized trial of estrogen plus progestin. In various countries, further studies then analyzed the incid...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.11.010
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To investigate if women with a history of having experienced intimate partner violence (IPV) who undertook caregiving would experience worse mental and physical health compared to those without caregiving roles. STUDY DESIGN AND MAIN OUTCOME MEASURES:IPV, caregiving history and data on covariates were colle...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.03.027
更新日期:2010-08-01 00:00:00