Abstract：
:Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and endometrial histopathology. Vasomotor disturbances were completely relieved. No recurrence of symptoms was recorded in the oestrogen-free week. Withdrawal bleedings were regular and slight, which was a positive experience for those women who had previously been treated with other oestrogen-progestogen regimens. In most patients inactive or weak secretory endometrial epithelium was found during treatment. Two women developed differing degrees of hyperplasia after 2.5 and 3 yr, respectively. This fact emphasizes the necessity of adding progestogens for at least 10 days each month even if the oestrogens and progestogens are administered separately. It may also be wise to perform an endometrial biopsy when sex hormones are administered on a long-term basis.
journal_name
Maturitasjournal_title
Maturitasauthors
Cullberg G,Knutsson F,Mattsson LAdoi
10.1016/0378-5122(84)90065-3subject
Has Abstractpub_date
1984-07-01 00:00:00pages
55-63issue
1eissn
0378-5122issn
1873-4111pii
0378-5122(84)90065-3journal_volume
6pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:Associations between depression and impaired functioning are well known and have been documented in numerous clinical, primary care and epidemiological studies. Reviews of this research have focused on the elderly. Recent studies suggest that women become increasingly vulnerable during the menopausal transition to dec...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.09.017
更新日期：2009-11-20 00:00:00
abstract：OBJECTIVES:The aim of this study is to determine if the depression in perimenopausal women is symptomatologically different than depression in premenopausal women, and if these depressive women are under more risk for depression when factors like premenstrual dysphoric syndrome, socio-economical status, vasomotor sympt...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.02.001
更新日期：2006-09-20 00:00:00
abstract：BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.maturitas.2016.02.015
更新日期：2016-05-01 00:00:00
abstract：:It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2010.03.027
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:Menopausal status is a common covariate in epidemiologic studies. Still, there are no standard definitions for menopausal status using observational data. This study assesses distinctions between menopausal status definitions using commonly collected epidemiologic data, and explores their impact on study out...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2010.04.015
更新日期：2010-09-01 00:00:00
abstract：:Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital sympt...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2007.05.003
更新日期：2007-09-20 00:00:00
abstract：OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(99)00056-0
更新日期：1999-12-15 00:00:00
abstract：OBJECTIVE:To compare the effects of (i) continuous low dosage C-19 progestin (dl-norgestrel, NG) plus cyclical conjugated estrogen (CEE) versus (ii) continuous low dosage C-21 progestin [medroxyprogesterone acetate (MPA)] plus CEE on postmenopausal vaginal bleeding, mood and somatic, psychosomatic and psychological sym...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(99)00053-5
更新日期：1999-10-24 00:00:00
abstract：OBJECTIVE:To examine whether physical activity during the last five years is related to later breast mammographic density in postmenopausal Greek women. METHODS:We designed a cross-sectional study in 724 women, of ages 45-67 years. An interview-administered questionnaire was used to obtain information on duration and ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2011.02.003
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:Qualitative studies show that women link menopause to the ageing process, and yet surprisingly little research has investigated how attitudes to ageing might shape women's experience of menopause, as well as their overall well-being at midlife. This study validated the Attitudes to Ageing Questionnaire (AAQ)...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.06.042
更新日期：2015-10-01 00:00:00
abstract：AIMS:Women in the West can now expect to live one third of their life in a postmenopausal state, and consequently in a state of estrogen deficiency. This can have a number of consequences, and many women suffer vasomotor symptoms during the climacteric. Estrogen deficiency can also result in changes to the skin, hair, ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:Alterations in sleep quality and metabolism during menopause are improved by menopausal hormone therapy (MHT). The mechanisms mediating these effects remain unclear. Orexin A (OxA) is a neuro-peptide that regulates sleep/wakefulness, food intake and metabolism. This study examined changes in plasma OxA levels...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2017.01.016
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. METHODS:Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiti...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00068-3
更新日期：2002-07-25 00:00:00
abstract：:Since the launch in 2008 by the National Osteoporosis Guideline Group (NOGG), of guidance for the diagnosis and management of osteoporosis in postmenopausal women and older men in the UK there have been significant advances in risk assessment and treatment. These have been incorporated into an updated version of the g...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2013.05.013
更新日期：2013-08-01 00:00:00
abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(94)00855-2
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism. METHOD:Postmenopausal women were treated with conjugated estrogens, 0.625 mg/medroxyprogesterone acetate, 2.5 or 5 mg (CEE/MPA) or tibolone 2.5 mg daily for 13 28-day cycles. Serum glucose and insuli...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.maturitas.2005.03.003
更新日期：2006-01-10 00:00:00
abstract：OBJECTIVE:Mandibular indices, measured on panoramic radiographs, may be useful screening implements for low skeletal bone mass density (BMD). Recent studies suggest that radiographic examination of mandible may constitute an effective process for the early diagnosis of osteoporosis. Biochemical markers of bone turnover...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2008.01.006
更新日期：2008-03-20 00:00:00
abstract：BACKGROUND:Studies assessing physical functionality with questions on ability to perform activities of daily living (ADLs) commonly make use of self- and informant-report measures. OBJECTIVES:Delineate the scenarios from which disagreement can arise and show evidence for the presence of disagreements when reporting on...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.06.012
更新日期：2012-10-01 00:00:00
abstract：:Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2015.07.004
更新日期：2015-10-01 00:00:00
abstract：:Ageing is accompanied with a progressive loss of muscle mass and force generating capacity. Ultimately, the muscle wasting and weakness may dramatically impact on mobility and the quality of life, where the elderly has increasing problems with performing activities of daily life, such as rising from a chair or climbin...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2012.07.015
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. METHODS:Eighty-six postmenopausal and 51 bilaterally ovariectomized ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.maturitas.2004.03.013
更新日期：2005-01-10 00:00:00
abstract：:The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(81)90003-7
更新日期：1981-08-01 00:00:00
abstract：OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(03)00247-0
更新日期：2004-02-20 00:00:00
abstract：:Worldwide, the number of menopausal women is increasing. They present with complex medical issues that lie beyond the traditional scope of gynaecologists and general practitioners (GPs). The European Menopause and Andropause Society (EMAS) therefore provides a holistic model of care for healthy menopause (HM). The HM ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.06.018
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:The activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis. METHODS:Utilizing a cohort of 39 postmenopausa...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.03.014
更新日期：2012-10-01 00:00:00
abstract：:The aim of this chronobiological study was to investigate temporal correlations in the circadian patterns of 6 hormones, namely somatotrophic hormone (STH), prolactin (PRL), cortisol (F), aldosterone (ALD), insulin (IRI) and C-peptide (CP), assayed in systemic blood serum drawn at 07:00, 10:00, 13:00, 16:00, 19:00 and...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(85)90024-6
更新日期：1985-07-01 00:00:00
abstract：:Vitamin D receptor (VDR) gene polymorphisms and the risks for various breast and ovarian cancers have been reported in many epidemiological studies. However, the associations between VDR gene polymorphisms and the risk for each type of cancer are unclear. The aim of this meta-analysis was to evaluate the associations ...
journal_title：Maturitas
pub_type： 杂志文章,meta分析
doi：10.1016/j.maturitas.2015.03.010
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.07.009
更新日期：2005-06-16 00:00:00
abstract：OBJECTIVE:To determine the percentage of endometrial hyperplasia positive for p53 expression in both spontaneously occurring cases or following the use of unopposed estradiol. METHODS:Fifty-four postmenopausal patients with endometrial hyperplasia diagnosed by endometrial biopsy and hysteroscopy were recruited to this...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00326-2
更新日期：2003-03-28 00:00:00
abstract：:The management of medications in persons with frailty presents challenges. There is evidence of inappropriate prescribing and a lack of consensus among healthcare professionals on the judicious use of medications, particularly for patients with more severe frailty. This study reviews the evidence on the use of commonl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.04.212
更新日期：2019-08-01 00:00:00
