Abstract:
OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) in uterine artery wall. METHODS:The uterine artery intima samples were obtained in connection with surgery of 21 postmenopausal and 51 premenopausal women. The amount of FC, CE and phospholipid fatty acids were measured by gas chromatography after extraction and fractionation and these lipid values were related to menopausal status, age and serum total and low-density lipoprotein (LDL) cholesterol levels. RESULTS:Premenopausal females had significantly less intimal FC (161 +/- 50 vs. 407 +/- 276 microg/100 mg wet weight, P = 0.003) and CE (19 +/- 34 vs. 305 +/- 348 microg/100 mg wet weight, P = 0.050) and smaller proportion of linoleic acid out of all phospholipid fatty acids (4.2 vs. 7.2%, P = 0.002) than postmenopausal women after adjustment with age. The content of CE (r = 0.34, P = 0.025) and the FC-to-CE ratio (r = -0.45, P = 0.002) correlated with age in premenopausal but not in postmenopausal women. Moreover, the intimal content of CE correlated with the percentage of intimal phospholipid linoleic acid in postmenopausal women (r = 0.79, P = 0.020). The same was true for FC (r = 0.73, P < 0.001). CONCLUSIONS:These results indicate that CE and FC accumulation into the wall of uterine artery depends on menopausal status, independently of age, and that the phospholipid long-chain fatty acid composition differs significantly between premenopausal and postmenopausal women. This suggests that estrogens may be involved in the regulation of artery wall lipid composition.
journal_name
Maturitasjournal_title
Maturitasauthors
Jokela H,Salomäki A,Lehtimäki T,Teisala K,Heinonen PK,Aine R,Rontu R,Punnonen Rdoi
10.1016/s0378-5122(03)00247-0keywords:
subject
Has Abstractpub_date
2004-02-20 00:00:00pages
115-22issue
2eissn
0378-5122issn
1873-4111pii
S0378512203002470journal_volume
47pub_type
杂志文章相关文献
MATURITAS文献大全abstract::We investigated the association between fear of falling (FoF) and motor imagery (MI) abilities in older people. Cross-sectional data from 3552 French older adults were used to conduct a multiple linear regression analysis looking at the association between FoF and MI abilities after controlling for several factors (e....
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.01.001
更新日期:2018-04-01 00:00:00
abstract::Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(88)90100-4
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVES:The study purpose was to evaluate the longitudinal effects, after 3 months and 1-year, of a perimenopausal health education intervention for mid-life women in Taiwan. METHODS:This study was conducted at two hospitals and their neighborhood communities (each included three subgroups, traditional Chinese, gyn...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2007.01.013
更新日期:2007-07-20 00:00:00
abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00138-9
更新日期:2000-08-31 00:00:00
abstract:OBJECTIVES:We conducted this study to examine premenopausal risk factors associated with premature ovarian failure (POF) and early menopause (EM) among Korean women. METHODS:A 73% of total women aged 30-69 at four districts in the KMCC (Korean Multi-center Cancer Cohort) was participated in this study during 2002-2003...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.04.001
更新日期:2007-09-20 00:00:00
abstract::Age-related changes in the concentrations of the main plasma electrolytes and in the urinary excretion of some of these ions have been examined in 436 pre-menopausal and 117 post-menopausal women. The main changes up to the menopause were decreases in the mean plasma potassium, calcium and total protein concentrations...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(82)90055-x
更新日期:1982-12-01 00:00:00
abstract::Although age is the most crucial predictor of a woman's reproductive capacity, it is assumed that there is still a risk of pregnancy in menopause transition, as occasional spontaneous ovulation is possible. Moreover, age alone is not sufficient to contraindicate the use of any contraceptive method, whether hormonal or...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.02.017
更新日期:2014-05-01 00:00:00
abstract::Estrogen is a well-known mitogen in human breast epithelium but the action of progestogen is complex and incompletely understood. During the last years, accumulating data from animal, clinical and observational studies suggest a proliferative effect in breast tissue when progestogen is added to estrogen. Findings in s...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2004.06.008
更新日期:2004-09-24 00:00:00
abstract:OBJECTIVES:To design a valid and reliable questionnaire, the Malaysian Osteoporosis Knowledge Tool (MOKT), to assess the knowledge of postmenopausal osteoporotic women in Malaysia, on osteoporosis and its treatment. METHODS:A 40-item instrument was designed and tested in this study. The scores ranged from 1 to 40, whi...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2008.04.006
更新日期:2008-06-20 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.07.009
更新日期:2005-06-16 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of two sex hormones on normal mammary gland of female rats. METHODS:Forty 250-day-old female rats, 20 of them with offspring and 20 not, were ovariectomized and, divided into 4 subgroups in order to receive one of the following subcutaneous treatment: est...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.09.007
更新日期:2005-08-16 00:00:00
abstract::Premature ovarian failure (POF) is common, affecting approximately 1% of women. It is defined as gonadal failure before the age of 40 and patients may clinically present with either primary or secondary amenorrhoea. This review concentrates on the clinical aspects of POF, with sequential discussion on the aetiology an...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(95)00966-3
更新日期:1996-02-01 00:00:00
abstract::From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(85)90041-6
更新日期:1985-09-01 00:00:00
abstract::Two-thirds of patients with type 2 diabetes mellitus (T2DM) have arterial hypertension. Hypertension increases the incidence of both micro- and macrovascular complications in these patients, while the co-existence of these two major risk factors leads to a four-fold increased risk for cardiovascular disease (CVD) comp...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2018.03.013
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate gynecologists' knowledge of the WHI study, and its repercussions on their attitudes and practice 3 years after publication. DESIGN:A self-administered, anonymous questionnaire containing 19 questions was sent to 6000 gynecologists, members of the São Paulo Society ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.06.022
更新日期:2007-02-20 00:00:00
abstract::Pain has been associated with cognitive problems in pain patients. This study evaluated the extent to which experiences of pain are associated with cognitive performance in a community sample of mid-life women, and the contribution of depressive symptoms to this association. A cross-sectional analysis was used with da...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.10.013
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to evaluate the effects of low doses of hormone replacement therapy (HRT) in normal young postmenopausal women. METHODS:In an open trial healthy, non-obese postmenopausal women received for 2 years a low-dose continuous combined HRT (LD-HRT) containing 1mg estradiol+0.5 mg n...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.10.007
更新日期:2008-01-20 00:00:00
abstract:OBJECTIVES:To better define the longitudinal changes in renal function, to examine the associated risk factors, and to investigate whether there is an independent association of decline in renal function with presence of carotid plaque in a middle-aged and elderly healthy population. METHODS:245 healthy individuals (9...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.07.014
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The use of hormone replacement therapy (HRT) declined strongly in many countries after publication of the WHI-study. The purpose of the present study was to investigate HRT usage patterns and motives for initiation, temporary discontinuation, and permanent discontinuation of HRT use among Norwegian women. ME...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.07.010
更新日期:2009-09-20 00:00:00
abstract::Sera were sampled from 83 people (pre- and post-menopausal women and men). Climacteric symptoms of 23 women were treated with conjugated estrogen. Sera were sampled serially until the 21st day of estrogen administration. Serum concentrations of 40 protein components were measured by micro single radial immunodiffusion...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(91)90282-u
更新日期:1991-03-01 00:00:00
abstract::Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the lit...
journal_title:Maturitas
pub_type: 杂志文章,实务指引
doi:10.1016/j.maturitas.2019.08.006
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:A large body of work has investigated the relationship between menopausal factors and negative well-being (e.g. anxiety and depressive symptoms), but less is known about positive well-being and its correlates among midlife women. This study tests two models with both positive and negative well-being indices ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.03.001
更新日期:2015-06-01 00:00:00
abstract::Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(98)00056-5
更新日期:1998-09-20 00:00:00
abstract::It is important for our aging population to remain active, particularly those with chronic diseases, like Parkinson disease (PD), which limit mobility. Recent studies in older adults and people with PD suggest dance interventions provide various motor benefits. The literature for dance in PD is growing, but many knowl...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.02.007
更新日期:2015-05-01 00:00:00
abstract::Beneficial effects on health of limiting food intake for certain periods of time have been recognized for a long time. While many diets can produce short-term weight loss, most fail to result in a long-lasting impact. Current data suggest that intermittent fasting may be beneficial for overall health and wellbeing. Ho...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.08.007
更新日期:2014-11-01 00:00:00
abstract::To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00111-0
更新日期:2000-05-29 00:00:00
abstract::In the past decade, the leading international cardiology societies have released statements that emphasize the importance of sex-specific reporting of the findings of clinical trials in cardiovascular research. To find out whether this has led to improvement, we compared sex-specific reporting of efficacy and safety o...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.09.007
更新日期:2021-02-01 00:00:00
abstract::Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital sympt...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.05.003
更新日期:2007-09-20 00:00:00
abstract:OBJECTIVES:Bone mineral density (BMD) and development of osteoporosis are partly determined by genetic factors. The associations between one of suggested candidate, apolipoprotein E (apo E) genotype to bone mineral density (BMD) and bone biochemical markers was studied in 464 subjects recruited from a population-based ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00084-5
更新日期:2000-01-15 00:00:00
abstract:OBJECTIVE:To compare the effects of (i) continuous low dosage C-19 progestin (dl-norgestrel, NG) plus cyclical conjugated estrogen (CEE) versus (ii) continuous low dosage C-21 progestin [medroxyprogesterone acetate (MPA)] plus CEE on postmenopausal vaginal bleeding, mood and somatic, psychosomatic and psychological sym...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00053-5
更新日期:1999-10-24 00:00:00