Abstract:
OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland biopsies were taken from the minor labial salivary glands (n=6), submandibular glands (n=5) and parotid gland (n=1) from women at different ages. METHODS:total RNA extracted from the tissue samples was reverse-transcripted (RT) to single-stranded cDNA, and the RT-polymerase chain reaction (RT-PCR) product was subjected to nucleotide sequencing to confirm the match with ER cDNA. Immunohistochemistry (IHC) with a monoclonal ER antibody (ER-ICA, Abbott) and Western blot analysis with monoclonal antibody against ER-related antigen (ER-D5, Amersham) were performed on the biopsies taken from the postmenopausal women. RESULTS:ER mRNA was expressed in 18/20 (90%) and 20/20 (100%) of the mucosal biopsies in the postmenopausal and 19-year-old women, respectively. The expression of mRNA was detected in all the submandibular gland samples, in the single parotid gland, as well as, in 4/6 (67%) of the labial glands. ER expression could not be detected by IHC, indicating either a very low level of expressed protein or difficulties in recognizing the epitopes by IHC. However, Western blot demonstrated 8/8 (100%) of the mucosal biopsies of postmenopausal women positive for ER-related antigen. CONCLUSIONS:the presence of ER mRNA and immunoreactive ER protein suggests that estrogens have a biological role in oral mucosa and salivary glands.
journal_name
Maturitasjournal_title
Maturitasauthors
Leimola-Virtanen R,Salo T,Toikkanen S,Pulkkinen J,Syrjänen Sdoi
10.1016/s0378-5122(00)00138-9keywords:
subject
Has Abstractpub_date
2000-08-31 00:00:00pages
131-7issue
2eissn
0378-5122issn
1873-4111pii
S0378-5122(00)00138-9journal_volume
36pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVES:To test the hypothesis that differences by gender will be observed in the association of hip fracture risk with stages of cognitive impairment; and to explore the association between Petersen's "mild cognitive impairment" (MCI) and DSM-5 "mild neurocognitive disorder" (MND). STUDY DESIGN:A community sample ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.12.007
更新日期:2018-03-01 00:00:00
abstract:UNLABELLED:Social engagement provides dynamic stimulation for older individuals that influences cognition. Grandparenting is an increasingly popular form of childcare that provides social activity for older adults. OBJECTIVE:To investigate the relationship between grandparenting, as a form of social engagement, and co...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.03.013
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00124-9
更新日期:2000-06-30 00:00:00
abstract:OBJECTIVE:To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. DESIGN:A 3-year non-comparative prospective clinical trial. SUBJECT...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2003.07.002
更新日期:2004-05-28 00:00:00
abstract::The aim of this chronobiological study was to investigate temporal correlations in the circadian patterns of 6 hormones, namely somatotrophic hormone (STH), prolactin (PRL), cortisol (F), aldosterone (ALD), insulin (IRI) and C-peptide (CP), assayed in systemic blood serum drawn at 07:00, 10:00, 13:00, 16:00, 19:00 and...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(85)90024-6
更新日期:1985-07-01 00:00:00
abstract::Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(98)00059-0
更新日期:1998-11-16 00:00:00
abstract:OBJECTIVES:The objectives of the study were to find the prevalence of major depressive disorder (MDD) in male climacteric outpatients in Japan, and to determine whether symptoms on the Aging Males' Symptoms (AMS) scale scores differed between patients with and without MDD, with the aim of increasing the specificity of ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.04.001
更新日期:2006-01-20 00:00:00
abstract::Pain has been associated with cognitive problems in pain patients. This study evaluated the extent to which experiences of pain are associated with cognitive performance in a community sample of mid-life women, and the contribution of depressive symptoms to this association. A cross-sectional analysis was used with da...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.10.013
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To examine Chinese middle-aged women's health and wellbeing and the associated biosocial correlates. STUDY DESIGN:This study used a cross-sectional design, including selected retrospectively collected information on the final menstrual period, drawn from the 2013 wave of the China Health and Retirement Long...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.10.008
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To describe the characteristics, metabolic control and health-related quality of life (HRQL) of type 2 diabetes mellitus (T2DM) geriatric patients. STUDY DESIGN:Cross-sectional descriptive study of consecutive patients attended at a geriatric outpatient clinic in a tertiary hospital over three months. Socio...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2011.05.001
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2006.11.001
更新日期:2007-04-20 00:00:00
abstract:OBJECTIVE:The activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis. METHODS:Utilizing a cohort of 39 postmenopausa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.03.014
更新日期:2012-10-01 00:00:00
abstract::Androgen insensitivity syndrome (AIS) is one of the most common sexual developmental disorders. According to the grade of the remaining androgen receptor (AR) function, AIS is classified as complete (CAIS), partial (PAIS) or mild (MAIS). In CAIS, the prevalence of germ cell tumours is increased compared with the gener...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2019.06.004
更新日期:2019-09-01 00:00:00
abstract::Menopause is a time of anatomic, physiological and psychological changes that often influence in the sexuality of aging female. Being sexual functioning an important aspect of health and well-being, doctors should have an holistic approach reassuring about the possibility of treating the various symptoms. The central ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(02)00150-0
更新日期:2002-08-30 00:00:00
abstract::Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.12.006
更新日期:2012-03-01 00:00:00
abstract::Perimenopause is an imprecise period in woman over 40 years of age, which comprises the time between the moment that the first changes in the menstrual cycle appear and the year following the definitive cessation of the menses. Besides irregular bleeding, many women also complain of hot flashes and other characteristi...
journal_title:Maturitas
pub_type: 杂志文章,实务指引
doi:10.1016/j.maturitas.2012.12.010
更新日期:2013-03-01 00:00:00
abstract::From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 1...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2008.09.010
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:Whether menopausal stage is associated with abnormalities in serum lipid and lipoprotein profiles remains unclear; studies have been conducted mostly in Western populations. This study aimed to examine the prevalence of lipid and lipoprotein abnormalities by recently updated menopausal stages in middle-aged ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.12.016
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:We investigated the association of visceral fat with the metabolic syndrome (MetS) and its separate components; the associations of both physical activity and muscle strength with the MetS and its separate components independent of visceral fat. Furthermore, we studied these associations within participants w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.06.015
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To date, no worldwide studies have been conducted to estimate the biological age of five organs using clinical biomarkers that are associated with the aging status. Therefore, we conducted this study to develop the models for estimating the biological age of five organs (heart, lung, liver, pancreas, and kid...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.04.008
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:Menopausal status is a common covariate in epidemiologic studies. Still, there are no standard definitions for menopausal status using observational data. This study assesses distinctions between menopausal status definitions using commonly collected epidemiologic data, and explores their impact on study out...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.04.015
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:Modern data on endometrial cancer (EC) incidence demonstrate that it is one of the most prevalent gynecologic malignancies. It is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism differently contribute into susceptibility to described types of this disea...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.04.017
更新日期:2006-07-20 00:00:00
abstract::Globally our populations are ageing and with this trend, there is a rise in chronic disease. We know that lifestyle and environment are significant contributors to risk for disease, quality of life and function. Despite this representing an opportunity to improve health and quality of life in ageing, there is a paucit...
journal_title:Maturitas
pub_type: 社论
doi:10.1016/j.maturitas.2016.07.004
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00224-9
更新日期:2001-09-28 00:00:00
abstract::Population health outcomes are shaped by complex interactions between individuals and the environments in which they live, work and play. Environments encompass streets and buildings (physical environment), attitudes, supports and relationships with others (social environment), as well as social and political systems ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.07.011
更新日期:2009-09-20 00:00:00
abstract::Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.07.004
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.07.001
更新日期:2013-10-01 00:00:00
abstract::The recreational use of methamphetamine (METH, or ice) is a global burden. It pervades and plagues contemporary society; it has been estimated that there are up to 35 million users worldwide. METH is a highly addictive psychotropic compound which acts on the central nervous system, and chronic use can induce psychotic...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2018.12.003
更新日期:2019-03-01 00:00:00
abstract::During the past 50 years, the prevalence of a cluster of chronic, inactivity-related diseases including obesity, insulin resistance and type 2 diabetes mellitus (T2DM), collectively referred to as 'metabolic syndrome' (MetS) has reached global epidemic proportions. Appropriate exercise training is a clinically proven,...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.05.015
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this internation...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.maturitas.2003.12.012
更新日期:2004-07-15 00:00:00