Exercise and type 2 diabetes: new prescription for an old problem.

Abstract:

:During the past 50 years, the prevalence of a cluster of chronic, inactivity-related diseases including obesity, insulin resistance and type 2 diabetes mellitus (T2DM), collectively referred to as 'metabolic syndrome' (MetS) has reached global epidemic proportions. Appropriate exercise training is a clinically proven, cost-effective, primary intervention that delays and in many cases prevents the health burdens associated with MetS. Indeed, there is no single intervention with greater efficacy than physical exercise to reduce the risk of virtually all chronic diseases simultaneously. However compliance to National guidelines for physical activity remains low, with "a lack of time" the most frequently cited barrier to exercise participation by adults, irrespective of age, sex and ethnic background. Part of the growing apathy to modify lifestyle habits is that current public health recommendations may be unrealistic and unattainable for the majority of the populace. Hence, there is an urgent need for innovations in exercise prescription that can be incorporated into daily living and induce clinically beneficial health outcomes. Here we focus attention on a novel form of exercise prescription, high-intensity interval training (HIT), and provide evidence that HIT is a time-efficient and well-tolerated therapeutic intervention to improve cardio-metabolic health in a number of pre-clinical and clinical populations.

journal_name

Maturitas

journal_title

Maturitas

authors

Bird SR,Hawley JA

doi

10.1016/j.maturitas.2012.05.015

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

311-6

issue

4

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(12)00199-5

journal_volume

72

pub_type

杂志文章,评审
  • Dose proportionality study of four doses of an estradiol transdermal system, Estradot.

    abstract:OBJECTIVES:To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot, in healthy postmenopausal women and to evaluate the wear and irritation properties of the ETS. METHODS:In an open label, single-dose, randomized, four-period crossover study, healthy postmenopausal wome...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(03)00189-0

    authors: Hossain M,Quebe-Fehling E,Sergejew T,Schmidt G,Skerjanec A,Ibarra de Palacios P,Krinsky L

    更新日期:2003-11-20 00:00:00

  • Oral, water-soluble combined estrogen/calcium preparation for postmenopausal therapy.

    abstract:OBJECTIVES:Estrogen is often prescribed for symptoms and sequelae of ovarian estrogen loss after menopause. METHODS:To assess efficacy and acceptability of a new, highly soluble estrogen-calcium preparation, we formulated a water-soluble powdered combination of estrogen (0.625 mg estrone piperazine sulfate) and calciu...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(00)00218-8

    authors: Downey D,Spencer SJ,Deghenghi R,Jaffe RB

    更新日期:2001-04-20 00:00:00

  • A review of select vitamins and minerals used by postmenopausal women.

    abstract:OBJECTIVES:The purpose of this review is to summarize the effectiveness of select vitamins, minerals and trace elements in postmenopausal women for their effects on bone health, cardiovascular health, breast cancer, cognition and vasomotor symptoms. METHODS:Review of the relevant literature and results from recent cli...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2010.06.003

    authors: Dennehy C,Tsourounis C

    更新日期:2010-08-01 00:00:00

  • Effect of hormone replacement therapy on uterine fibroids in postmenopausal women--a 3-year study.

    abstract:OBJECTIVE:The aim of this prospective 3-year clinical study was to examine the effect of hormone replacement therapy (HRT) on uterine fibroid growth among postmenopausal women. METHODS:Thirty-seven postmenopausal women with uterine solitary fibroids were recruited randomly for HRT in a 3-year program. All participants...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00159-7

    authors: Yang CH,Lee JN,Hsu SC,Kuo CH,Tsai EM

    更新日期:2002-09-30 00:00:00

  • Treatment with percutanous testosterone gel in postmenopausal women with decreased libido--effects on sexuality and psychological general well-being.

    abstract:OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2005.01.002

    authors: Nathorst-Böös J,Flöter A,Jarkander-Rolff M,Carlström K,Schoultz Bv

    更新日期:2006-01-10 00:00:00

  • Chinese women's health and wellbeing in middle life: Unpacking the influence of menopause, lifestyle activities and social participation.

    abstract:OBJECTIVES:To examine Chinese middle-aged women's health and wellbeing and the associated biosocial correlates. STUDY DESIGN:This study used a cross-sectional design, including selected retrospectively collected information on the final menstrual period, drawn from the 2013 wave of the China Health and Retirement Long...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2020.10.008

    authors: Falkingham J,Evandrou M,Qin M,Vlachantoni A

    更新日期:2021-01-01 00:00:00

  • Risk of onset of menopausal symptoms in periods surrounding menopause.

    abstract:OBJECTIVE:To assess the risk of onset of menopausal symptoms at different periods surrounding menopause, and variations in this risk according to age at menopause and type of menopause. METHODS:We analyzed the 27,897 women participating in the French E3N cohort study who reached menopause during a 10-year follow-up pe...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.09.012

    authors: Sabia S,Fournier A,Mesrine S,Boutron-Ruault MC,Clavel-Chapelon F

    更新日期:2007-12-20 00:00:00

  • Factors affecting bone loss around menopause in women without HRT: a prospective study.

    abstract:OBJECTIVES:The present study evaluated the effects of menopause and other putative bone loss modifying factors on bone mineral density (BMD) change. METHODS:The study population, 396 healthy women aged 48-59 years with no history of hormone replacement therapy (HRT) use or any bone affecting disease or medications, wa...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(03)00150-6

    authors: Sirola J,Kröger H,Honkanen R,Jurvelin JS,Sandini L,Tuppurainen MT,Saarikoski S,OSTPRE Study Group.

    更新日期:2003-07-25 00:00:00

  • The role of clinical breast examination in cancer screening for women at average risk: A mini review.

    abstract::As the debate about the potential benefits and harms of screening mammography continues, it is timely to consider the role of clinical breast examination in screening for women at average risk of breast cancer. This article reviews the results from clinical trials and discusses the varied recommendations around the wo...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2016.07.011

    authors: Brennan ME

    更新日期:2016-10-01 00:00:00

  • Characteristics of female outpatients with urinary incontinence participating in a 6-month observational study in 14 European countries.

    abstract:OBJECTIVE:To describe the characteristics of women seeking treatment for symptoms of urinary incontinence (UI) in European countries. DESIGN:Prospective urinary incontinence research (PURE) was a 6-month, observational, pan-European study, primarily aimed at determining the direct costs of urinary incontinence treatme...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.maturitas.2005.09.003

    authors: Sykes D,Castro R,Pons ME,Hampel C,Hunskaar S,Papanicolaou S,Quail D,Samsioe G,Voss S,Wagg A,Monz BU

    更新日期:2005-11-30 00:00:00

  • The role of depressive symptomatology in peri- and post-menopause.

    abstract:OBJECTIVES:There is evidence that menopausal symptoms manifested at peri-menopause occur less frequently when compared to the symptoms experienced at post-menopause. The aim of this study was to investigate this and to test the hypothesis that depressive symptomatology mediates the relationship between menopausal stage...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.03.007

    authors: Borkoles E,Reynolds N,Thompson DR,Ski CF,Stojanovska L,Polman RC

    更新日期:2015-06-01 00:00:00

  • Fatty acid and cholesterol composition of the uterine artery intima in relation to menopausal status, age, and serum cholesterol.

    abstract:OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(03)00247-0

    authors: Jokela H,Salomäki A,Lehtimäki T,Teisala K,Heinonen PK,Aine R,Rontu R,Punnonen R

    更新日期:2004-02-20 00:00:00

  • Comparing TCM textbook descriptions of menopausal syndrome with the lived experience of London women at midlife and the implications for Chinese medicine research.

    abstract::Almost without exception clinical research seeking to evaluate the effectiveness of Chinese medicine relies on TCM textbook knowledge - accessed directly or via practitioners' clinical usage - in order to frame its hypotheses. Recent historical research shows that these textbooks, products of a politically directed pr...

    journal_title:Maturitas

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.maturitas.2010.03.021

    authors: Scheid V,Ward T,Tuffrey V

    更新日期:2010-08-01 00:00:00

  • Managing hot flushes in men after prostate cancer--a systematic review.

    abstract:CONTEXT AND OBJECTIVE:The aim of this study was to describe hot flushes in men with prostate cancer, and their treatment methods. METHOD:A systematic review was conducted of the literature indexed between 1966 and 2009 on the MEDLINE, the ISI Web of Knowledge, Cinahl and PsycINFO. Of 252 articles identified, 32 were s...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.10.017

    authors: Frisk J

    更新日期:2010-01-01 00:00:00

  • Declining socioeconomic differences in the use of menopausal and postmenopausal hormone therapy in Finland.

    abstract:OBJECTIVE:Sales figures for the use of menopausal and postmenopausal hormone therapy in Finland show a rapid increase during the 1980s continued into the first half of the 1990s. Hormone therapy use became very common in Finland compared to many other Western countries. The aim of our study was to investigate the socio...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(99)00027-4

    authors: Topo P,Luoto R,Hemminki E,Uutela A

    更新日期:1999-08-16 00:00:00

  • Thyrotropin-releasing hormone and the menopausal hot flash.

    abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/0378-5122(81)90003-7

    authors: Molnar GW

    更新日期:1981-08-01 00:00:00

  • Adrenocortical steroids, bone mineral content and endometrial condition in post-menopausal women.

    abstract::In 23 post-menopausal women, serum levels of cortisol, unconjugated dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS), testosterone, unconjugated and total oestrone and prolactin were measured before and during an ACTH test. Significant positive correlations were found between basal levels of DHA an...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(82)90037-8

    authors: Brody S,Carlström K,Lagrelius A,Lunell NO,Rosenborg L

    更新日期:1982-08-01 00:00:00

  • Hormone replacement therapy: the benefits in tailoring the regimen and dose.

    abstract::Despite the clear benefits of long-term hormone replacement therapy (HRT), the majority of patients tend to undergo short-term treatment. The cyclical bleedings induced by the sequential progestogen administration are often unacceptable namely in the elderly postmenopausal women. At the standard doses HRT preparations...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(01)00281-x

    authors: Gambacciani M,Genazzani AR

    更新日期:2001-12-14 00:00:00

  • Effects of tibolone and raloxifene on health-related quality of life and sexual function.

    abstract:OBJECTIVES:Study to compare the effects of tibolone and raloxifene on health-related quality of life, sexuality and vaginal atrophy. METHODS:A double-blind, randomized study was conducted in 308 osteopenic, but otherwise healthy, postmenopausal women (mean age 66 years) who received tibolone 1.25mg/day or raloxifene 6...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.maturitas.2007.07.005

    authors: Nijland EA,Weijmar Schultz WC,Davis SR

    更新日期:2007-10-20 00:00:00

  • Bone turnover markers in statin users: a population-based analysis from the Camargo Cohort Study.

    abstract:OBJECTIVE:To analyze the effects of statin use on bone turnover markers (BTM), in participants from a large population-based cohort. SUBJECTS AND METHODS:Cross-sectional study that included 2431 subjects (1401 women and 930 men) from the Camargo Cohort. We analyzed the differences in serum BTM between statin or non-st...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.02.003

    authors: Hernández JL,Olmos JM,Romaña G,Martinez J,Castillo J,Yezerska I,Ramos C,González-Macías J

    更新日期:2013-05-01 00:00:00

  • Effect of estrogen replacement therapy on speed of sound at multiple skeletal sites.

    abstract:OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(00)00124-9

    authors: Weiss M,Ben Shlomo A,Hagag P,Rapoport M,Ish-Shalom S

    更新日期:2000-06-30 00:00:00

  • Risk-reducing mastectomy in BRCA1/2 mutation carriers: factors influencing uptake and timing.

    abstract:INTRODUCTION:Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screening or risk-reducing mastectomy (RRM). Both options have a high physical and psychosexual impact. The aim of this study is to investigate who chooses when to undergo RRM. METHODS:BRCA1/2 ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.10.017

    authors: van Driel CM,Eltahir Y,de Vries J,Jaspers JP,Oosterwijk JC,Mourits MJ,de Bock GH

    更新日期:2014-02-01 00:00:00

  • The influence of hormone replacement therapy on skin ageing: a pilot study.

    abstract:OBJECTIVES:We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, trans...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(00)00225-5

    authors: Sator PG,Schmidt JB,Sator MO,Huber JC,Hönigsmann H

    更新日期:2001-07-25 00:00:00

  • A systematic review of social support interventions for caregivers of people with dementia: Are they doing what they promise?

    abstract:OBJECTIVE:Social support interventions for caregivers of persons with dementia (PwD) are important because informal carers often rely on their social networks for support. This systematic review synthesises findings from research on social support interventions, and examines their methodological quality and effectivene...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2015.12.008

    authors: Dam AE,de Vugt ME,Klinkenberg IP,Verhey FR,van Boxtel MP

    更新日期:2016-03-01 00:00:00

  • Hormonal replacement regimens and bleeding.

    abstract::Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossibl...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(99)00069-9

    authors: Dören M

    更新日期:2000-01-01 00:00:00

  • The impact of attitudes towards the menopause on women's symptom experience: a systematic review.

    abstract:OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.10.016

    authors: Ayers B,Forshaw M,Hunter MS

    更新日期:2010-01-01 00:00:00

  • Risk factors for clinically diagnosed uterine fibroids in women around menopause.

    abstract:OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.01.013

    authors: Parazzini F

    更新日期:2006-09-20 00:00:00

  • Increased menopausal symptoms among Afro-Colombian women as assessed with the Menopause Rating Scale.

    abstract:BACKGROUND:Increased frequency and severity of menopausal symptoms have been associated to black race. However, this situation has not been described in any Latin American population. OBJECTIVE:Compare frequency and severity of menopausal symptoms among Afro and non-Afro Hispanic Colombian climacteric women. METHODS:...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.12.002

    authors: Monterrosa A,Blumel JE,Chedraui P

    更新日期:2008-02-20 00:00:00

  • Long-term effects of percutaneous estradiol on bone loss and bone metabolism in postmenopausal hysterectomized women.

    abstract:OBJECTIVE:To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day). METHODS:The bone mineral density of the lumbar spine (LS) and of the proximal femur (PF) was ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(97)00081-9

    authors: Devogelaer JP,Lecart C,Dupret P,De Nayer P,Nagant De Deuxchaisnes C

    更新日期:1998-01-12 00:00:00

  • Is vitamin D deficiency related to a higher risk of hospitalization and mortality in veterans with heart failure?

    abstract:OBJECTIVES:25-hydroxyvitamin D [25(OH)D] deficiency is related to an increase in cardiovascular risk but the association between low 25(OH)D and hospitalization and mortality in heart failure (HF) patients remains unclear. The objective of this study was therefore to determine whether 25(OH)D deficiency is associated w...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2019.11.005

    authors: Aparicio-Ugarriza R,Salguero D,Mohammed YN,Ferri-Guerra J,Baskaran DJ,Mirabbasi SA,Rodriguez A,Ruiz JG

    更新日期:2020-02-01 00:00:00