Effect of estrogen replacement therapy on speed of sound at multiple skeletal sites.

Abstract:

OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omnisense (Omnisense) and were matched by years since menopause. Speed of sound (SOS) was measured at the distal radius (RAD), mid-shaft tibia (TIB), fifth metatarsus (MTR) and proximal phalanx (PLX). RESULTS:143 ERT users for 5.2+/-3.6 years were compared with 139 ERT non-users (age: 57.0+/-5.3 and 57.5+/-5.5, respectively). Both groups were 7.1+/-5.0 years since menopause. SOS, expressed in T-score units, was higher at the RAD in ERT users as compared to ERT non-users (-0.55+/-1.30 and -1.36+/-1.60, respectively, P<0.0001), and at the TIB (-0.73+/-1.34 and -1.28+/-1.45, respectively, P=0. 003). Same trend was observed at the MTR and PLX, but not statistically significant because of fewer observations. In early post menopause period, the ERT-non users RAD data shows an annual SOS decrease of 0.17 versus annual increase of 0.12 T-score units (P=0.037). Similar effect is observed at the TIB, though not statistically significant (non-users decrease of 0.20 vs. users increase of 0.08 T-score units/year, P=0.086). CONCLUSIONS:SOS measurements by Omnisense at multiple skeletal sites support the ERT protective effect on bone.

journal_name

Maturitas

journal_title

Maturitas

authors

Weiss M,Ben Shlomo A,Hagag P,Rapoport M,Ish-Shalom S

doi

10.1016/s0378-5122(00)00124-9

keywords:

subject

Has Abstract

pub_date

2000-06-30 00:00:00

pages

237-43

issue

3

eissn

0378-5122

issn

1873-4111

pii

S0378512200001249

journal_volume

35

pub_type

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