Abstract:
BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be one of the causes of the increased cardiovascular risk associated with postmenopausal status. Medial and intimal calcification may increase arterial stiffness. The aim of our study was to assess the relationship of OPG, OPN and MGP with aortic pulse wave velocity (aPWV) as a marker of arterial stiffness in postmenopausal women. MATERIALS AND METHODS:Circulating OPG, OPN and serum total MGP were measured in 144 postmenopausal women using the enzyme-linked immunosorbent assay method. Aortic PWV was determined by an oscillometric method. RESULTS:Osteoprotegerin correlated with age (p<0.001, r=0.27), aPWV (p<0.001, r=0.32) and hypersensitive C reactive protein (hsCRP) (p<0.001, r=0.37), OPN correlated directly with hsCRP (p<0.001, r=0.39) and inversely with high density lipoprotein cholesterol (p=0.02, r=-0.02). No significant association was found between total MGP and clinical, biochemical and vascular parameters. The correlation between OPG and aPWV persisted even after the adjustment for various potential confounders (p=0.02, r=0.19). In multiple regression analysis in the whole study population the most important predictors of aPWV were OPG (β=0.230, p=0.006), hsCRP (β=0.212, p=0.01) and systolic blood pressure (β=0.163, p=0.04). After exclusion of patients treated with statins the independent predictors were hsCRP (β=0.275, p=0.005) and OPG (β=0.199, p=0.04). CONCLUSION:Circulating OPG, but not OPN and total MGP, is associated with aPWV and may be a marker of the increased arterial stiffness and cardiovascular risk in postmenopausal women.
journal_name
Maturitasjournal_title
Maturitasauthors
Albu A,Fodor D,Bondor C,Crăciun AMdoi
10.1016/j.maturitas.2013.07.001subject
Has Abstractpub_date
2013-10-01 00:00:00pages
146-50issue
2eissn
0378-5122issn
1873-4111pii
S0378-5122(13)00219-3journal_volume
76pub_type
杂志文章相关文献
MATURITAS文献大全abstract::A group of 72 postmenopausal women were treated for 4 weeks with vaginal suppositories containing 0.5 or 1.0 mg of estriol. The two different doses achieved an identical significant improvement of urogenital symptoms, while a dose-related effect seen to be on climacteric complaints, according to a good absorption of e...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(95)00943-f
更新日期:1995-11-01 00:00:00
abstract::In the past decade, the leading international cardiology societies have released statements that emphasize the importance of sex-specific reporting of the findings of clinical trials in cardiovascular research. To find out whether this has led to improvement, we compared sex-specific reporting of efficacy and safety o...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.09.007
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Physical multimorbidity, defined as the presence of two or more chronic physical conditions, is widespread and reduces life expectancy and quality of life in older adults. Sedentary behavior (SB) is increasingly identified as a risk factor for a range of chronic physical conditions, independent of physical a...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.01.007
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.10.002
更新日期:2008-01-20 00:00:00
abstract:CONTEXT AND OBJECTIVE:The aim of this study was to describe hot flushes in men with prostate cancer, and their treatment methods. METHOD:A systematic review was conducted of the literature indexed between 1966 and 2009 on the MEDLINE, the ISI Web of Knowledge, Cinahl and PsycINFO. Of 252 articles identified, 32 were s...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.10.017
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:C-telopeptide crosslaps (CTX) and bone-specific alkaline phosphatase (BAP) do not provide sufficient sensitivity and specificity for diagnosis of osteoporosis. Cathepsin K (CatK), osteoprotegerin (OPG), and receptor activator of nuclear factor κB ligand (total (t) and soluble (s) RANKL) play an important rol...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.01.005
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00259-6
更新日期:2002-02-26 00:00:00
abstract:OBJECTIVE:New regimens and routes of administration of hormonal replacement therapy (HRT) in climateric women are becoming available. Since there is no information on the neuroendocrine effects of sequential combined treatment with 17 beta-estradiol and a progestin, the present study evaluated the neuroendocrine, clini...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(97)00073-x
更新日期:1997-12-15 00:00:00
abstract::In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00010-5
更新日期:2002-04-15 00:00:00
abstract:OBJECTIVE:To examine the prevalence and correlates of foot problems in older women over a 6-year period. STUDY DESIGN:Women aged 70-75 years who participated in the Australian Longitudinal Study on Women's Health completed a postal questionnaire incorporating questions relating to demographics, major medical condition...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.08.010
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Changes in biochemical markers of bone formation and resorption were followed over the course of 1 year in premenopausal, perimenopausal and early postmenopausal women. METHODS:Sixty-four subjects were analyzed, grouped according to their menstrual pattern, menopausal complaints and endocrinological paramete...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(01)00248-1
更新日期:2002-01-30 00:00:00
abstract:OBJECTIVES:To investigate if women with a history of having experienced intimate partner violence (IPV) who undertook caregiving would experience worse mental and physical health compared to those without caregiving roles. STUDY DESIGN AND MAIN OUTCOME MEASURES:IPV, caregiving history and data on covariates were colle...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(94)90100-7
更新日期:1994-11-01 00:00:00
abstract::Despite the clear benefits of long-term hormone replacement therapy (HRT), the majority of patients tend to undergo short-term treatment. The cyclical bleedings induced by the sequential progestogen administration are often unacceptable namely in the elderly postmenopausal women. At the standard doses HRT preparations...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(01)00281-x
更新日期:2001-12-14 00:00:00
abstract:INTRODUCTION:Obesity, defined as an excess of total body fat, is a matter of concern all over the world, and its prevalence is still increasing among elderly people. OBJECTIVES:To examine whether sedentary behaviour (hours sitting per day) is associated with higher risk of central obesity, overweight-obesity and overf...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2012.09.001
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Leydig cell tumours of the ovary are very rare benign neoplasms, frequently associated with symptoms of virilisation, in postmenopausal patients. Only four cases of bilateral Leydig tumours have been reported in the literature. CASE REPORT:We report an additional case of bilateral presentation. A 77-year-ol...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.11.013
更新日期:2007-06-20 00:00:00
abstract:AIM:The aim was to investigate bone mineral density (BMD) in breast cancer patients with positive estrogen receptor (ER) tumor status. METHODS:The participants were 110 postmenopausal breast cancer patients with positive estrogen receptor (ER+) tumor status. Two hundred and sixty-one age-matched, healthy postmenopausa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.11.012
更新日期:2007-07-20 00:00:00
abstract::Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol,...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(86)90035-6
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. METHODS:Eighty-six postmenopausal and 51 bilaterally ovariectomized ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2004.03.013
更新日期:2005-01-10 00:00:00
abstract:OBJECTIVES:To analyze independently in men and women the incidence rate of and risk factors for hip fracture in a southern European population. Illiteracy, dementia, clinically significant depression and disability were factors to receive special emphasis. STUDY DESIGN:A community sample of 4803 individuals aged over ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.12.009
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. RESULTS AND CONCLUSIONS:Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascu...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(01)00270-5
更新日期:2001-10-31 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant furth...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00302-4
更新日期:2002-05-20 00:00:00
abstract::Although age is the most crucial predictor of a woman's reproductive capacity, it is assumed that there is still a risk of pregnancy in menopause transition, as occasional spontaneous ovulation is possible. Moreover, age alone is not sufficient to contraindicate the use of any contraceptive method, whether hormonal or...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.02.017
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN:Cross-secti...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2017.11.007
更新日期:2018-02-01 00:00:00
abstract::Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(87)90045-4
更新日期:1987-04-01 00:00:00
abstract::Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(98)00056-5
更新日期:1998-09-20 00:00:00
abstract::Stroke represents one of the most important menaces to public health. A number of modifiable and non-modifiable risk factors have been identified and studied in detail; among those, obesity, the new world epidemic, seems to be one of the most important in terms of prevention. The discovery of the secretory role of the...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.09.002
更新日期:2011-12-01 00:00:00
abstract::The identification of early biochemical predictors of osteoarthritis (OA) has been the focus of much research over the past few years. However, it still is unclear whether current biochemical markers can be used in prognostic risk assessment of OA. The aim of this systematic review is to evaluate the possible prognost...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.04.004
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00224-9
更新日期:2001-09-28 00:00:00
abstract::Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.04.011
更新日期:2011-07-01 00:00:00