Patients with osteoporosis prefer once weekly to once daily dosing with alendronate.

Abstract:

OBJECTIVES:Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this international study was to assess preference for the weekly or daily dosing regimen of alendronate among postmenopausal women with osteoporosis. METHODS:This randomised open-label crossover study was conducted at 45 study sites in 19 countries. Four hundred and six postmenopausal women with osteoporosis were assigned randomly to treatment with either alendronate 70 mg once weekly for 4 weeks followed by alendronate 10 mg once daily for 4 weeks or vice versa. The main outcome was the responses of the participants to the Dosing Regimen Questionnaire administered at the end of the study. RESULTS:Of the participants expressing a preference, 84% preferred the once weekly dosing regimen with alendronate to the once daily dosing regimen. In addition, the once weekly regimen was considered by 87% of the participants to be more convenient and was the regimen most of the participants (84%) would be more willing to take for a long period of time (P < 0.001 for each parameter). CONCLUSIONS:The majority of postmenopausal women with osteoporosis preferred the once weekly to the once daily dosing regimen of alendronate. Physicians should consider patient preference for dosing regimen when selecting the appropriate treatment for osteoporosis.

journal_name

Maturitas

journal_title

Maturitas

authors

Kendler D,Kung AW,Fuleihan Gel-H,González González JG,Gaines KA,Verbruggen N,Melton ME

doi

10.1016/j.maturitas.2003.12.012

keywords:

subject

Has Abstract

pub_date

2004-07-15 00:00:00

pages

243-51

issue

3

eissn

0378-5122

issn

1873-4111

pii

S0378512204000362

journal_volume

48

pub_type

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