Abstract：
:Age-related changes in the concentrations of the main plasma electrolytes and in the urinary excretion of some of these ions have been examined in 436 pre-menopausal and 117 post-menopausal women. The main changes up to the menopause were decreases in the mean plasma potassium, calcium and total protein concentrations, accompanied by increases in the renal excretion of calcium and inorganic phosphate. The decrease in plasma total calcium concentration was completely accounted for by the fall in albumin and globulin concentrations. The main changes observed at the menopause were increases in plasma sodium, total calcium, inorganic phosphate and magnesium concentrations, an increase in the plasma "anion gap" and increases in the renal excretion of sodium, magnesium and inorganic phosphate. All these changes were reversed by treatment with ethinyl oestradiol. The causes and significance of some of these changes are discussed, particularly the menopausal rises in plasma sodium concentration and in the plasma "anion gap".
journal_name
Maturitasjournal_title
Maturitasauthors
Hodgkinson Adoi
10.1016/0378-5122(82)90055-xsubject
Has Abstractpub_date
1982-12-01 00:00:00pages
247-56issue
4eissn
0378-5122issn
1873-4111pii
0378-5122(82)90055-Xjournal_volume
4pub_type
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