Abstract：
OBJECTIVES:This paper examines the evidence supporting testosterone replacement in aging males. Confounding factors contributing to low testosterone levels and challenges to diagnosis of the andropause will also be considered. METHODS:A thorough review using an integrative approach citing published literature and the ongoing work of the authors. A search was performed using National Library of Medicine PubMed. Electronic and print journals available at the Texas Medical Center library were also considered. RESULTS:Information based on collective trials in older men has added to evidence for benefits and side effects of testosterone replacement inferred from studies in younger hypogonadal patients and animal models. In general, most investigators agree with short-term safety but long-term safety is unknown. Testosterone therapy in aging males improves body composition, certain domains of brain function and may also decrease cardiovascular risk in biological models. Measurable clinical effects are less apparent. Potential risks include erythrocytosis, edema, gynecomastia, and prostate stimulation. The possibility of increased risk of clinically significant prostate cancer and cardiovascular disease has been considered. CONCLUSION:The search continues for an ideal replacement androgen and larger long-term studies are needed. At this time, androgen replacement is on a case-by-case basis and prostate cancer screening should be completed prior to instituting therapy. Routine androgen replacement therapy for aging males will have significant economic implications, and is not currently recommended.
journal_name
Maturitasjournal_title
Maturitasauthors
Tan RS,Culberson JWdoi
10.1016/s0378-5122(03)00083-5keywords:
subject
Has Abstractpub_date
2003-05-30 00:00:00pages
15-27issue
1eissn
0378-5122issn
1873-4111pii
S0378512203000835journal_volume
45pub_type
杂志文章,评审相关文献
MATURITAS文献大全abstract：INTRODUCTION:Obesity, defined as an excess of total body fat, is a matter of concern all over the world, and its prevalence is still increasing among elderly people. OBJECTIVES:To examine whether sedentary behaviour (hours sitting per day) is associated with higher risk of central obesity, overweight-obesity and overf...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.09.001
更新日期：2012-12-01 00:00:00
abstract：:Older people with chronic disease have great potential to benefit from their medications but are also at high risk of harm from their medications. The use of medications is particularly important for symptom control and disease progression in older people. Under-treatment means older people can miss out on the potenti...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.06.006
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:mitral annular calcification (MAC) occurs mainly in middle-aged and elderly patients and can lead to serious clinical consequences. Male predominance in the prevalence of coronary disease is well-established. Paradoxically, the prevalence of MAC, which is theoretically based on the same etiological mechanism...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00120-1
更新日期：2000-07-31 00:00:00
abstract：:In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00010-5
更新日期：2002-04-15 00:00:00
abstract：OBJECTIVE:To examine the prevalence and correlates of foot problems in older women over a 6-year period. STUDY DESIGN:Women aged 70-75 years who participated in the Australian Longitudinal Study on Women's Health completed a postal questionnaire incorporating questions relating to demographics, major medical condition...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2010.08.010
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Study to compare the effects of tibolone and raloxifene on health-related quality of life, sexuality and vaginal atrophy. METHODS:A double-blind, randomized study was conducted in 308 osteopenic, but otherwise healthy, postmenopausal women (mean age 66 years) who received tibolone 1.25mg/day or raloxifene 6...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.maturitas.2007.07.005
更新日期：2007-10-20 00:00:00
abstract：OBJECTIVE:To correlate circulating hormone levels with the clinical and biological features of the tumors in menopausal breast cancer patients. DESIGN:Circulating hormone levels were measured in 161 previously untreated menopausal breast cancer patients within 72 h of their planned surgery. The obtained hormone levels...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.07.001
更新日期：2009-09-20 00:00:00
abstract：OBJECTIVES:To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. STUDY DESIGN:This was a single-blind randomi...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2019.10.014
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in estradiol bioavailability and concentrations. METHODS:In an open study, 23 healthy postmenopausal women were treated consecutively with 0.5, 1.0 and 1.5 mg estradiol daily as a transdermal gel. E...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00101-8
更新日期：2000-04-28 00:00:00
abstract：OBJECTIVES:Over the past decade, dietary choices and nutrition have proven to be major modulators of bone mineral density (BMD) in men and women. We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population. METHODS:BMDs were measured...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.001
更新日期：2007-01-20 00:00:00
abstract：OBJECTIVES:The menopause rating scale (MRS) has been developed as a modern tool for the assessment of menopausal complaints. It combines in practice excellent applicability and a good reliability, and there are normal values for the population available. For further practical evaluation, the MRS was applied in order to...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00177-8
更新日期：2000-12-29 00:00:00
abstract：INTRODUCTION:Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. METHODS:A prospective randomized...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2013.06.016
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:To estimate the prevalence of disability and its association with morbidity and other social and health-related factors among Spain's non-institutionalized elderly population. METHODS:Cross-sectional survey, by home-based personal interview, covering a sample of 4000 subjects representative of the non-insti...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2003.10.004
更新日期：2004-08-20 00:00:00
abstract：:Associations between depression and impaired functioning are well known and have been documented in numerous clinical, primary care and epidemiological studies. Reviews of this research have focused on the elderly. Recent studies suggest that women become increasingly vulnerable during the menopausal transition to dec...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.09.017
更新日期：2009-11-20 00:00:00
abstract：OBJECTIVES:This study examined factors associated with self-reported physical and mental health, focusing on caregiving status and the availability of social supports and financial resources. METHODS:Two bivariate analyses were performed to examine the sociodemographic characteristics as well as perceived health outco...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2011.10.011
更新日期：2012-01-01 00:00:00
abstract：:The management of medications in persons with frailty presents challenges. There is evidence of inappropriate prescribing and a lack of consensus among healthcare professionals on the judicious use of medications, particularly for patients with more severe frailty. This study reviews the evidence on the use of commonl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.04.212
更新日期：2019-08-01 00:00:00
abstract：AIMS:Women in the West can now expect to live one third of their life in a postmenopausal state, and consequently in a state of estrogen deficiency. This can have a number of consequences, and many women suffer vasomotor symptoms during the climacteric. Estrogen deficiency can also result in changes to the skin, hair, ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(96)82006-8
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVES:Estrogen is often prescribed for symptoms and sequelae of ovarian estrogen loss after menopause. METHODS:To assess efficacy and acceptability of a new, highly soluble estrogen-calcium preparation, we formulated a water-soluble powdered combination of estrogen (0.625 mg estrone piperazine sulfate) and calciu...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00218-8
更新日期：2001-04-20 00:00:00
abstract：:Pheochromocytomas are catecholamine producing neuroendocrine tumors that can be adrenal or extra-adrenal in origin. The classic symptoms of pheochromocytoma are headache, palpitation, anxiety and diaphoresis and the tumor can occur at any age with equal gender distribution. In patients with an established mutation or ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2013.12.009
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVES:To compare the metabolic and endocrinological effects of estradiol valerate/cyproterone acetate (EV/CPA) to a regimen of conjugated estrogens/medroxyprogesterone acetate (CE/MPA) in postmenopausal women. METHODS:Lipid profile, endocrinological parameters, coagulation factors, renin and angiotensinogen were ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(97)00042-x
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:In this study we aimed to pilot test the hypothesis that in women who are severely bothered by their menopausal complaints, improvement of menopausal symptoms is associated with an improvement in self-perceived work ability. STUDY DESIGN:This retrospective cohort study assessed the work ability of first-time...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.10.015
更新日期：2019-02-01 00:00:00
abstract：:Estrogen is a well-known mitogen in human breast epithelium but the action of progestogen is complex and incompletely understood. During the last years, accumulating data from animal, clinical and observational studies suggest a proliferative effect in breast tissue when progestogen is added to estrogen. Findings in s...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2004.06.008
更新日期：2004-09-24 00:00:00
abstract：:The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.10.008
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:Despite their public health importance, little is known about associations between modifiable lifestyles, quality of life (QOL), and psychiatric symptoms in men. We investigated relationships between QOL, obesity, mobility and lifestyle in Australian men, including whether associations were mediated by anxie...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.06.024
更新日期：2017-09-01 00:00:00
abstract：:In order to assess the possible role of circulating immunoreactive inhibin (INH) during the menopausal transition, two groups of subjects were studied. Four were normal volunteers, three of whom had developed their first symptoms of cycle irregularity at age 45-46 years, the fourth being aged 37, a volunteer for a stu...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(93)90026-e
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant furth...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(01)00302-4
更新日期：2002-05-20 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate the effects of two sex hormones on normal mammary gland of female rats. METHODS:Forty 250-day-old female rats, 20 of them with offspring and 20 not, were ovariectomized and, divided into 4 subgroups in order to receive one of the following subcutaneous treatment: est...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.09.007
更新日期：2005-08-16 00:00:00
abstract：:Tibolone (Livial) has advantages over other forms of hormone replacement therapy (HRT); it is easy to use and does not induce withdrawal bleeding in postmenopausal women. The evidence for the effect of tibolone on climacteric symptoms is reviewed and shows that tibolone is effective in reducing vasomotor symptoms and ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/0378-5122(94)00888-e
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Age-related hearing loss (ARHL) and depression are considered leading causes of disability in older adults. This cross-sectional study investigated the association between the severity of speech and high-frequency ARHL and depression, anxiety and stress in older adults. STUDY DESIGN:Cross-sectional study of...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.02.002
更新日期：2018-04-01 00:00:00
