Frailty and multimorbidity: Two related yet different concepts.

Abstract:

:The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death. The aim of the present paper is to conceptualize and differentiate these terms and to discuss their interrelations. We conclude that, yet related, they represent two different clinical conditions. Frailty identifies the increased vulnerability to stressors due to a dynamic, non-linear, and multidimensional depletion of physiological reserve and redundancy, whereas multimorbidity refers to the coexistence of two or more clinically manifest chronic diseases.

journal_name

Maturitas

journal_title

Maturitas

authors

Villacampa-Fernández P,Navarro-Pardo E,Tarín JJ,Cano A

doi

10.1016/j.maturitas.2016.10.008

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

31-35

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(16)30281-X

journal_volume

95

pub_type

杂志文章,评审
  • Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women.

    abstract:OBJECTIVE:New regimens and routes of administration of hormonal replacement therapy (HRT) in climateric women are becoming available. Since there is no information on the neuroendocrine effects of sequential combined treatment with 17 beta-estradiol and a progestin, the present study evaluated the neuroendocrine, clini...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(97)00073-x

    authors: Stomati M,Bersi C,Rubino S,Palumbo M,Comitini G,Genazzani AD,Santuz M,Petraglia F,Genazzani AR

    更新日期:1997-12-15 00:00:00

  • The effects of hormone replacement therapy on plasma lipids in type II diabetes.

    abstract:OBJECTIVES:The effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with non-insulin dependent diabetes mellitus (type II diabetes) is uncertain. METHODS:The effects of estrogen replacement therapy (ERT, conjugated equine estrogen0.625mg orally daily), combined estrogen and con...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(99)00112-7

    authors: Manwaring P,Morfis L,Diamond T,Howes LG

    更新日期:2000-03-31 00:00:00

  • Mental well-being in 5000 women participating in the 'Women-Plus' preventive medicine program.

    abstract::In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00010-5

    authors: Concin H,Ulmer H,Hefler L

    更新日期:2002-04-15 00:00:00

  • Depression and the incidence of urinary incontinence symptoms among young women: Results from a prospective cohort study.

    abstract:OBJECTIVE:To examine the association of depressive symptoms with subsequent urinary incontinence (UI) symptoms among young women. SUBJECTS AND METHODS:Data were from a cohort of 5391 young women (born 1973-1978) from the Australian Longitudinal Study on Women's Health. Generalised Estimating Equations (GEEs) were used...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.05.006

    authors: Mishra GD,Barker MS,Herber-Gast GC,Hillard T

    更新日期:2015-08-01 00:00:00

  • The age and symptomatology of natural menopause among United Arab Emirates women.

    abstract:OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(98)00010-3

    authors: Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

    更新日期:1998-06-17 00:00:00

  • Hormone replacement therapy: the benefits in tailoring the regimen and dose.

    abstract::Despite the clear benefits of long-term hormone replacement therapy (HRT), the majority of patients tend to undergo short-term treatment. The cyclical bleedings induced by the sequential progestogen administration are often unacceptable namely in the elderly postmenopausal women. At the standard doses HRT preparations...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(01)00281-x

    authors: Gambacciani M,Genazzani AR

    更新日期:2001-12-14 00:00:00

  • A new combination of conjugated equine oestrogens and medroxyprogesterone for treatment of climacteric complaints.

    abstract::Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and end...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(84)90065-3

    authors: Cullberg G,Knutsson F,Mattsson LA

    更新日期:1984-07-01 00:00:00

  • EMAS position statement: Bone densitometry screening for osteoporosis.

    abstract:INTRODUCTION:Osteoporosis and its consequent fractures is a major public health problem. AIM:To formulate a position statement on the use of bone densitometry in screening postmenopausal women for osteoporosis and in their management. MATERIALS AND METHODS:Literature review and consensus of expert opinion. RESULTS A...

    journal_title:Maturitas

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.maturitas.2010.09.009

    authors: Brincat M,Calleja-Agius J,Erel CT,Gambacciani M,Lambrinoudaki I,Moen MH,Schenck-Gustafsson K,Tremollieres F,Vujovic S,Rees M,Rozenberg S,EMAS.

    更新日期:2011-01-01 00:00:00

  • Prevalence of disability and associated social and health-related factors among the elderly in Spain: a population-based study.

    abstract:OBJECTIVES:To estimate the prevalence of disability and its association with morbidity and other social and health-related factors among Spain's non-institutionalized elderly population. METHODS:Cross-sectional survey, by home-based personal interview, covering a sample of 4000 subjects representative of the non-insti...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2003.10.004

    authors: Graciani A,Banegas JR,López-García E,Rodríguez-Artalejo F

    更新日期:2004-08-20 00:00:00

  • Compliance with long-term oral hormonal replacement therapy.

    abstract:OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0378-5122(95)00921-7

    authors: Eiken P,Kolthoff N

    更新日期:1995-09-01 00:00:00

  • Estrogens, progestins and lipid metabolism.

    abstract:OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(96)01012-2

    authors: Tikkanen MJ

    更新日期:1996-05-01 00:00:00

  • Effects of conjugated equine oestrogens with and without the addition of cyclical norgestrel on serum and urine electrolytes, and the biochemical indices of bone metabolism and liver function.

    abstract::Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(88)90100-4

    authors: Fletcher CD,Farish E,Dagen MM,Allam BF,Hart DM

    更新日期:1988-03-01 00:00:00

  • Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status.

    abstract:OBJECTIVES:The effects of supplemental testosterone on cognition, mood and wellbeing in ageing men are unclear. This study aimed to assess the effect of 12-months of oral testosterone supplementation on cognitive function, mood and quality of life in elderly men with low-normal gonadal status, not specifically selected...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2004.05.002

    authors: Haren MT,Wittert GA,Chapman IM,Coates P,Morley JE

    更新日期:2005-02-14 00:00:00

  • Peyronie's disease: review and recent advances.

    abstract::Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease hi...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.05.024

    authors: Langston JP,Carson CC 3rd

    更新日期:2014-08-01 00:00:00

  • Clinical evaluation, dose-finding and acceptability of AERODIOL, the pulsed estrogen therapy for treatment of climacteric symptoms.

    abstract::S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0378-5122(00)00175-4

    authors: Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime B

    更新日期:2001-01-31 00:00:00

  • Coronary heart disease in menopausal women: implications of primary and secondary prevention trials of hormones.

    abstract::In direct contrast to the observational studies, both primary and secondary prevention trials of female reproductive hormones have found no benefit for coronary heart disease (CHD). Basic science studies have elucidated several mechanisms by which estrogen may improve coronary arterial physiology and prevent pathology...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2005.02.015

    authors: Rossouw JE

    更新日期:2005-05-16 00:00:00

  • The prescription of hormone replacement therapy in Spain: differences between general practitioners and gynaecologists.

    abstract:OBJECTIVES:The purpose of this study was to determine the frequency with which hormone replacement therapy (HRT) was prescribed and to identify physician-related factors associated with the prescription of HRT in Spain. STUDY DESIGN:A descriptive cross-sectional survey based on a personal interview with a structured q...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.04.023

    authors: Castelo-Branco C,Ferrer J,Palacios S,Cornago S

    更新日期:2006-11-20 00:00:00

  • Hormonal replacement therapy and the skeletal system.

    abstract::The two most important risk factors for maintaining skeletal health are the bone mass obtained at skeletal maturity (peak bone mass) and the subsequent bone loss. Those women with a low peak bone mass and a rapid bone loss are thus at increased risk of developing osteoporosis in the future, and should be identified. T...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(90)90006-r

    authors: Christiansen C,Riis BJ

    更新日期:1990-09-01 00:00:00

  • The most bothersome symptom of vaginal atrophy: Evidence from the observational AGATA study.

    abstract:OBJECTIVES:Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN:Cross-secti...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.maturitas.2017.11.007

    authors: Palma F,Xholli A,Cagnacci A,as the writing group of the AGATA study.

    更新日期:2018-02-01 00:00:00

  • The longitudinal effects of a perimenopausal health education intervention on the mid-life women in Taiwan.

    abstract:OBJECTIVES:The study purpose was to evaluate the longitudinal effects, after 3 months and 1-year, of a perimenopausal health education intervention for mid-life women in Taiwan. METHODS:This study was conducted at two hospitals and their neighborhood communities (each included three subgroups, traditional Chinese, gyn...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.maturitas.2007.01.013

    authors: Tsao LI,Su MC,Hsiao PJ,Gau YM,An C,Lin KC

    更新日期:2007-07-20 00:00:00

  • Improvement of menopausal symptoms and the impact on work ability: A retrospective cohort pilot study.

    abstract:OBJECTIVE:In this study we aimed to pilot test the hypothesis that in women who are severely bothered by their menopausal complaints, improvement of menopausal symptoms is associated with an improvement in self-perceived work ability. STUDY DESIGN:This retrospective cohort study assessed the work ability of first-time...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2018.10.015

    authors: Geukes M,Anema JR,van Aalst MP,de Menezes RX,Oosterhof H

    更新日期:2019-02-01 00:00:00

  • On the different scenarios of disagreement between self- and informant-reports on an aged adults ability to perform activities of daily living.

    abstract:BACKGROUND:Studies assessing physical functionality with questions on ability to perform activities of daily living (ADLs) commonly make use of self- and informant-report measures. OBJECTIVES:Delineate the scenarios from which disagreement can arise and show evidence for the presence of disagreements when reporting on...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2012.06.012

    authors: Siordia C

    更新日期:2012-10-01 00:00:00

  • Prevention of postmenopausal bone loss with minimal uterine bleeding using low dose continuous estrogen/progestin therapy: a 2-year prospective study.

    abstract:OBJECTIVE:To re-examine the minimal effective dose of conjugated estrogen (CEE)-progestin hormone replacement on postmenopausal bone loss. DESIGN:A 2-year, prospective, open label, randomized study. SETTING:Department of Obstetrics and Gynecology of a university hospital. PARTICIPANTS:Fifty-two postmenopausal or oop...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(97)01110-9

    authors: Mizunuma H,Okano H,Soda M,Kagami I,Miyamoto S,Tokizawa T,Honjo S,Ibuki Y

    更新日期:1997-05-01 00:00:00

  • Early menarche and new onset of asthma: Results from the SAPALDIA cohort study.

    abstract:RATIONALE:The association between early menarche and new onset of asthma warrants further investigation in those aged >30 years. OBJECTIVES:Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), we investigated whether early menarche was associated with new onset of a...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2017.04.012

    authors: Hansen S,Probst-Hensch N,Bettschart R,Pons M,Leynaert B,Gómez Real F,Rochat T,Dratva J,Schneider C,Keidel D,Schindler C,Zemp E

    更新日期:2017-07-01 00:00:00

  • Menopausal symptoms and symptom clustering in Chinese women.

    abstract:OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(99)00056-0

    authors: Ho SC,Chan SG,Yip YB,Cheng A,Yi Q,Chan C

    更新日期:1999-12-15 00:00:00

  • Circulating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis.

    abstract:INTRODUCTION:The biological mechanisms associated with an inadequate response to treatment with bisphosphonates are not well known. This study investigates the association between circulating levels of sclerostin and estradiol with an inadequate clinical outcome to bisphosphonate therapy in women with postmenopausal os...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.08.007

    authors: Morales-Santana S,Díez-Pérez A,Olmos JM,Nogués X,Sosa M,Díaz-Curiel M,Pérez-Castrillón JL,Pérez-Cano R,Torrijos A,Jodar E,Rio LD,Caeiro-Rey JR,Reyes-García R,García-Fontana B,González-Macías J,Muñoz-Torres M

    更新日期:2015-12-01 00:00:00

  • Metformin intervention against ovarian toxicity during chemotherapy for early breast cancer: Study protocol for a randomized double-blind placebo-controlled trial.

    abstract:BACKGROUND:With the significant improvement of the cure rate and survival rate of cancer patients, the survivors face quality-of-life problems, such as a significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly as...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2020.04.010

    authors: Zhang J,Ma X,Li Y,Liu R,Li Y,Zhang P,Ren W,Cui P,Wang B,Zhang M,Jin Y,Li X,Wang S

    更新日期:2020-07-01 00:00:00

  • Menopausal hormone therapy use in relation to breast cancer incidence in 11 European countries.

    abstract:INTRODUCTION:The use of menopausal hormone therapy (MHT) has decreased in many countries in the past 10 years. This is a consequence of the initial publication of the results of the Women's Health Initiative (WHI) randomized trial of estrogen plus progestin. In various countries, further studies then analyzed the incid...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.11.010

    authors: Antoine C,Ameye L,Paesmans M,de Azambuja E,Rozenberg S

    更新日期:2016-02-01 00:00:00

  • Serum estrogen level after hormone replacement therapy and body mass index in postmenopausal and bilaterally ovariectomized women.

    abstract:OBJECTIVE:The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. METHODS:Eighty-six postmenopausal and 51 bilaterally ovariectomized ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2004.03.013

    authors: Yasui T,Uemura H,Umino Y,Takikawa M,Saito S,Kuwahara A,Matsuzaki T,Maegawa M,Furumoto H,Miura M,Irahara M

    更新日期:2005-01-10 00:00:00

  • Sexuality after breast cancer: a review.

    abstract::It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2010.03.027

    authors: Gilbert E,Ussher JM,Perz J

    更新日期:2010-08-01 00:00:00