Abstract:
:S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptability of S21400. One hundred and thirty four women were allocated a daily dose of 100-900 microg for 12 weeks. The doses of 100, 600 and 900 microg were given in two daily administrations, the doses of 200, 300 and 450 microg were given in one and two daily administrations. Oral progestogen was added the last 10-14 days of each cycle of estrogen therapy in all non-hysterectomized women. S21400 showed a dose-effect relationship and provided adequate estrogenisation in more than 80% of patients receiving a dose ranging from 200 to 600 microg daily. Hormonal impregnation was judged sufficient in 23% of women receiving the lowest dose (100 microg). It was often considered excessive for daily doses of 900 microg (36%). After 12 weeks of treatment, efficacy was similar whether the total daily dose was given in one or two administrations. Treatment was well tolerated and accepted, with only minor nasal events (prickling, sneezing). It was perceived by 92% of patients as good or excellent and 81% chose to continue the nasal treatment when it was offered to them. An initial dose of 300 microg per day provides an optimal efficacy/tolerability ratio. In summary, the pulsed estrogen therapy with AERODIOL in one daily administration offers a safe, well accepted and highly effective treatment to alleviate climacteric symptoms. It can be adapted easily to ensure optimal clinical efficacy.
journal_name
Maturitasjournal_title
Maturitasauthors
Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime Bdoi
10.1016/s0378-5122(00)00175-4keywords:
subject
Has Abstractpub_date
2001-01-31 00:00:00pages
181-9issue
3eissn
0378-5122issn
1873-4111pii
S0378512200001754journal_volume
37pub_type
临床试验,杂志文章,多中心研究相关文献
MATURITAS文献大全abstract:OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.02.261
更新日期:2015-05-01 00:00:00
abstract::The present study had two objectives: (1) to register the prevalence of a number of climacteric complaints in a Danish general population cohort and (2) retrospectively to test the validity of an association between climacteric complaints, menopausal development, occurrence of life events and social background. A post...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(93)90043-h
更新日期:1993-11-01 00:00:00
abstract::The effect of estradiol valerate (Progynova, 2 mg daily) on the renin--aldosterone system was studied in nine women after bilateral oophorectomy. Plasma renin activity (PRA) and the daily urinary excretion of aldosterone (dU-Ald) were determined 4 mth after the operation -- during which no estrogen was given -- and af...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(80)90041-9
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVES:Aging is associated with changes in resting energy expenditure (REE) and body composition. We investigated the association between age and changes in REE in men and women stratified by body mass index (BMI) categories (normal weight, overweight and obesity). We also examined whether the age-related decline i...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.12.023
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The higher risk of women developing autoimmune diseases suggests that immune system is mediated by sex steroids. OBJECTIVE:To review the effects of aging and menopause in immune system. METHODS:A systematic review of in vitro, animal and human studies involving aging and menopause and immune system was car...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.08.003
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0378-5122(03)00279-2
更新日期:2004-03-15 00:00:00
abstract:OBJECTIVE:We investigated, using color Doppler ultrasound, possible detectable blood changes of prolonged treatment with 17-beta-estradiol tablets on uterine artery blood flow, in a cohort of low risk postmenopausal women. METHODS:39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.07.004
更新日期:2005-04-11 00:00:00
abstract::The secretory endometrial protein PP14 was measured in serum from 49 healthy, early post-menopausal women receiving continuous combined oestradiol valerate/cyproterone acetate (2 mg E2V + 1 mg CPA daily) or placebo over a period of 2 years. In the hormone group, serum PP14 increased from 2.1 micrograms/l to a maximum ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(92)90060-h
更新日期:1992-08-01 00:00:00
abstract::To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00111-0
更新日期:2000-05-29 00:00:00
abstract:OBJECTIVES:25-hydroxyvitamin D [25(OH)D] deficiency is related to an increase in cardiovascular risk but the association between low 25(OH)D and hospitalization and mortality in heart failure (HF) patients remains unclear. The objective of this study was therefore to determine whether 25(OH)D deficiency is associated w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2019.11.005
更新日期:2020-02-01 00:00:00
abstract::A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch appli...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(91)90098-b
更新日期:1991-06-01 00:00:00
abstract::Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.12.006
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Given the asymptomatic nature of osteoporosis, a fragility fracture provides an opportunity to make the issue of osteoporosis relevant to patients. Patients who link their fragility fracture with osteoporosis are more likely to initiate osteoporosis treatment, yet to date, we know little about who is likely t...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.07.014
更新日期:2013-10-01 00:00:00
abstract::Gender inequalities in the financial resources in later life result from the combined effect of women's atypical life courses, which include interrupted employment records and periods of care provision, and the fact that pension systems have generally been slow in mitigating 'diversions' from continuous and full-time ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.02.015
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:With the significant improvement of the cure rate and survival rate of cancer patients, the survivors face quality-of-life problems, such as a significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly as...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.04.010
更新日期:2020-07-01 00:00:00
abstract::Combination therapy strategies for osteoporosis are reviewed in this article. Regimens including two antiresorptives agents increase BMD more than single therapy alone, but they have not proved to reduce fracture risk. The alternative of combining antiresorptives together with anabolics has gained more interest. There...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2005.08.011
更新日期:2006-04-20 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate bone protective effects of risedronate, atorvastatin, raloxifene and clomiphene citrate in ovariectomized rats. METHODS:Our study was conducted on 63 rats at Experimental Research Center of Celal Bayar University. Six-month-old rats were divided into seven groups. The...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.03.018
更新日期:2009-07-20 00:00:00
abstract::The Dallas Heart Study dataset was used to examine relationships between menopausal symptoms and depressive symptom severity in 384 women (37-73 years old) self-reporting as menopausal. Self-reported menopausal symptoms were grouped based on the Menopause-specific Quality of Life Questionnaire (MENQOL). Depressive sym...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.09.009
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Social support interventions for caregivers of persons with dementia (PwD) are important because informal carers often rely on their social networks for support. This systematic review synthesises findings from research on social support interventions, and examines their methodological quality and effectivene...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.12.008
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Frailty and cognitive impairment in late life increase the risk of mortality. Physical frailty is closely associated with cognitive impairment. The aim of the study was to examine the independent and interaction effects of frailty and cognitive impairment in predicting mortality. STUDY DESIGN:A nationally r...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.10.006
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2006.11.001
更新日期:2007-04-20 00:00:00
abstract:OBJECTIVES:To assess the prevalence of climacteric symptoms and the use of hormone replacement therapy in a former eastern European country. All 55-, 57-, 59- and 61-year-old women in Kladno in the Czech Republic were asked to participate in the study. METHOD:In 1993, 1505 women in Kladno of the Czech Republic were se...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(95)00965-5
更新日期:1996-02-01 00:00:00
abstract:AIM:The aim was to investigate bone mineral density (BMD) in breast cancer patients with positive estrogen receptor (ER) tumor status. METHODS:The participants were 110 postmenopausal breast cancer patients with positive estrogen receptor (ER+) tumor status. Two hundred and sixty-one age-matched, healthy postmenopausa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.11.012
更新日期:2007-07-20 00:00:00
abstract::There are few prospective data on temporal trends in overall sitting time for different domains of sitting. This study examined time trends over 6 years in total and domain-specific sitting time in mid-age Australian men and women. Self-report data from 5246 participants in four survey waves (2007, 2009, 2011, 2013) o...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.08.006
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To clarify the effect of programmed exercise (PE), performed for at least six weeks, on perceived stress (PS) in middle aged and old women. METHODS:A structured search was carried out in PubMed, Embase, Cochrane Library, Scielo, Web of Science and Scopus, from database inception through January 10, 2018, wit...
journal_title:Maturitas
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.maturitas.2018.05.004
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate gynecologists' knowledge of the WHI study, and its repercussions on their attitudes and practice 3 years after publication. DESIGN:A self-administered, anonymous questionnaire containing 19 questions was sent to 6000 gynecologists, members of the São Paulo Society ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.06.022
更新日期:2007-02-20 00:00:00
abstract::In 23 post-menopausal women, serum levels of cortisol, unconjugated dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS), testosterone, unconjugated and total oestrone and prolactin were measured before and during an ACTH test. Significant positive correlations were found between basal levels of DHA an...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(82)90037-8
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00138-9
更新日期:2000-08-31 00:00:00
abstract:OBJECTIVE:Elevation of blood pressure and heart rate increase the risk of cardiovascular disease. Administration of estrogens does not affect heart rate but may decrease 24 h blood pressure. In this study, we tested the effect of the estro-progestogenic compound tibolone. METHODS:Thirty healthy, post-menopausal women ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2003.08.011
更新日期:2004-06-15 00:00:00
abstract:INTRODUCTION:The complexity of care required by many older people living in long-term care (LTC) facilities poses challenges that can lead to potentially avoidable referrals to a hospital emergency department (ED). The Aged Residential Care Intervention Project (ARCHIP) ran an implementation study to evaluate a multidi...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.08.014
更新日期:2018-11-01 00:00:00