Abstract：
:A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch applied for 3-5 days on 20 cm2 of skin. There was no evidence of pharmacokinetic advantage with the patch, and the day to day intra-individual variations were even greater with patch than with gel. There were no cutaneous side effects with the gel, but unacceptable skin reactions, including itching, vesicular rash and residual pigmentation, were present in 58% of patients during patch use. Therefore a combination, in a small skin area, of adhesive, occlusive effect and high oestradiol concentration does not appear appropriate in hot and humid climate.
journal_name
Maturitasjournal_title
Maturitasauthors
Sentrakul P,Chompootaweep S,Sintupak S,Tasanapradit P,Tunsaringkarn K,Dusitsin Ndoi
10.1016/0378-5122(91)90098-bsubject
Has Abstractpub_date
1991-06-01 00:00:00pages
151-4issue
2eissn
0378-5122issn
1873-4111pii
0378-5122(91)90098-Bjournal_volume
13pub_type
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