Abstract:
OBJECTIVES:To study the fracture reducing potential of hormonal replacement therapy (HRT) in recent postmenopausal women in a primary preventive scenario. METHODS:Prospective controlled comprehensive cohort trial: 2016 healthy women aged 45-58 years, from three to 24 months past last menstrual bleeding were recruited from a random sample of the background population. Mean age was 50. 8+/-2.8 years, and the number of person years followed was 9335.3. There were two main study arms: a randomised arm (randomised to HRT; n=502, or not; n=504) and a non-randomised arm (on HRT; n=221, or not; n=789 by own choice). First line HRT was oral sequential oestradiol/norethisterone in women with intact uterus and oral continuous oestradiol in hysterectomised women. RESULTS:After five years, a total of 156 fractures were sustained by 140 women. There were 51 forearm fractures in 51 women. By intention-to-treat analysis (n=2016), overall fracture risk was borderline statistically significantly reduced (RR=0.73, 95% CI: 0.50-1.05), and forearm fracture risk was significantly reduced (RR=0.45, 95% CI: 0.22-0.90) with HRT. Restricting the analysis to women who had adhered to their initial allocation of either HRT (n=395) or no HRT (n=977) showed a significant reduction in both the overall fracture risk (RR=0.61, 95% CI: 0.39-0.97) and the risk of forearm fractures (RR=0.24, 95% CI: 0.09-0.69). Compliance with HRT was 65% after five years. CONCLUSIONS:It is possible to reduce the number of forearm fractures and possibly the total number of fractures in recent postmenopausal women by use of HRT as primary prevention.
journal_name
Maturitasjournal_title
Maturitasauthors
Mosekilde L,Beck-Nielsen H,Sørensen OH,Nielsen SP,Charles P,Vestergaard P,Hermann AP,Gram J,Hansen TB,Abrahamsen B,Ebbesen EN,Stilgren L,Jensen LB,Brot C,Hansen B,Tofteng CL,Eiken P,Kolthoff Ndoi
10.1016/s0378-5122(00)00158-4keywords:
subject
Has Abstractpub_date
2000-10-31 00:00:00pages
181-93issue
3eissn
0378-5122issn
1873-4111pii
S0378512200001584journal_volume
36pub_type
临床试验,杂志文章,随机对照试验相关文献
MATURITAS文献大全abstract::Cardiovascular disease is the leading cause of death in women throughout the United States and Europe. Despite efforts to raise awareness, the sex-specific risk factors are still poorly recognized in both regions, and many women do not identify cardiovascular disease as a primary threat. During midlife, the incidence ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2018.11.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(95)00983-3
更新日期:1996-04-01 00:00:00
abstract::Tibolone (Livial) has advantages over other forms of hormone replacement therapy (HRT); it is easy to use and does not induce withdrawal bleeding in postmenopausal women. The evidence for the effect of tibolone on climacteric symptoms is reviewed and shows that tibolone is effective in reducing vasomotor symptoms and ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(94)00888-e
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:Bone mineral density (BMD) and development of osteoporosis are partly determined by genetic factors. The associations between one of suggested candidate, apolipoprotein E (apo E) genotype to bone mineral density (BMD) and bone biochemical markers was studied in 464 subjects recruited from a population-based ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00084-5
更新日期:2000-01-15 00:00:00
abstract:OBJECTIVE:Impaired vision and hearing are common among older adults and have been shown to reduce functional independence and to reduce quality of life. This cohort study investigated the cross-sectional and temporal associations between objectively measured dual sensory impairment (DSI) and retirement from employment....
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.03.318
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism. METHOD:Postmenopausal women were treated with conjugated estrogens, 0.625 mg/medroxyprogesterone acetate, 2.5 or 5 mg (CEE/MPA) or tibolone 2.5 mg daily for 13 28-day cycles. Serum glucose and insuli...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.maturitas.2005.03.003
更新日期:2006-01-10 00:00:00
abstract:OBJECTIVE:To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. DESIGN:A 3-year non-comparative prospective clinical trial. SUBJECT...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2003.07.002
更新日期:2004-05-28 00:00:00
abstract::Gynecological literature is replete with multiple papers on sexually transmitted infections (STIs) in young women. Although those past the reproductive prime may well be at lower risk for STIs than women in the peak reproductive years, STIs are regularly seen in the older cohort and are a cause for significant morbidi...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.05.003
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:The present study evaluated the effects of menopause and other putative bone loss modifying factors on bone mineral density (BMD) change. METHODS:The study population, 396 healthy women aged 48-59 years with no history of hormone replacement therapy (HRT) use or any bone affecting disease or medications, wa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00150-6
更新日期:2003-07-25 00:00:00
abstract::Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.07.004
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN:Cross-secti...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2017.11.007
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To correlate circulating hormone levels with the clinical and biological features of the tumors in menopausal breast cancer patients. DESIGN:Circulating hormone levels were measured in 161 previously untreated menopausal breast cancer patients within 72 h of their planned surgery. The obtained hormone levels...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2009.07.001
更新日期:2009-09-20 00:00:00
abstract::As the debate about the potential benefits and harms of screening mammography continues, it is timely to consider the role of clinical breast examination in screening for women at average risk of breast cancer. This article reviews the results from clinical trials and discusses the varied recommendations around the wo...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.07.011
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00138-9
更新日期:2000-08-31 00:00:00
abstract:OBJECTIVES:The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed. METHODS:Review of the relevant literature and results from recent clinical trials. RESULT...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2008.02.008
更新日期:2008-05-20 00:00:00
abstract:OBJECTIVES:Whether menopausal stage is associated with abnormalities in serum lipid and lipoprotein profiles remains unclear; studies have been conducted mostly in Western populations. This study aimed to examine the prevalence of lipid and lipoprotein abnormalities by recently updated menopausal stages in middle-aged ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.12.016
更新日期:2015-04-01 00:00:00
abstract::Gender inequalities in the financial resources in later life result from the combined effect of women's atypical life courses, which include interrupted employment records and periods of care provision, and the fact that pension systems have generally been slow in mitigating 'diversions' from continuous and full-time ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.02.015
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of two sex hormones on normal mammary gland of female rats. METHODS:Forty 250-day-old female rats, 20 of them with offspring and 20 not, were ovariectomized and, divided into 4 subgroups in order to receive one of the following subcutaneous treatment: est...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.09.007
更新日期:2005-08-16 00:00:00
abstract::While the benefits of progestins in hormonal replacement therapy are well recognized as far as endometrial protection is concerned the data on breast tissue and the cardiovascular system are contentious. Following the Women's Health Initiative study, the Million Women Study and The Women's International Study of Long-...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2008.12.019
更新日期:2009-04-20 00:00:00
abstract:OBJECTIVE:To assess the symptomatology of menopause and the use of hormone therapy among women in Spain. METHODS:A survey conducted on a representative sample of 300 women aged 45-55 in Madrid. The instrument included closed- and open-ended questions about demographic and socio-economic information, health and reprodu...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.01.011
更新日期:2005-11-01 00:00:00
abstract::The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.10.008
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Our pilot study tested the efficacy, acceptability and tolerability of DHA supplementation in addition to calcium and vitamin D in individuals with osteopenia. STUDY DESIGN:40 participants were randomised to either algal oil containing 400mg docosahexanoic acid (DHA) daily or placebo. All participants recei...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2011.10.004
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Modern data on endometrial cancer (EC) incidence demonstrate that it is one of the most prevalent gynecologic malignancies. It is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism differently contribute into susceptibility to described types of this disea...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.04.017
更新日期:2006-07-20 00:00:00
abstract::This is a narrative review of new ideas and concepts related to differences between men and women in their risk of developing dementia or Alzheimer's disease (AD). We introduce the concept of dimorphic neurology and the distinction between sex and gender. We then provide three examples of risk factors related to sex a...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.05.008
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screening or risk-reducing mastectomy (RRM). Both options have a high physical and psychosexual impact. The aim of this study is to investigate who chooses when to undergo RRM. METHODS:BRCA1/2 ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.10.017
更新日期:2014-02-01 00:00:00
abstract::Most health decisions occur in contexts of scientific uncertainty, the "grey zone" of decision-making and many decisions faced by menopausal women are no exception. These contexts are characterized either by scientific evidence that points to a balance between harms and benefits within or between options, or by the ab...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.01.013
更新日期:2009-07-20 00:00:00
abstract:OBJECTIVES:The aim of this study was to observe hysterectomized postmenopausal women (without progestogen, which could interfere in the results), using oral-conjugated oestrogen 0.625 mg daily (n=13) or 17beta-estradiol transdermal patches delivering 50 microg daily (n=10) during 12 months, and to evaluate the treatmen...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/s0378-5122(03)00159-2
更新日期:2003-09-25 00:00:00
abstract:OBJECTIVES:To investigate the effect of estrogen alone or combined with progestin on the amount and synthesis of skin collagen in postmenopausal women. METHODS:Forty-three early postmenopausal women were enrolled into this open, non-randomized parallel-groups study. Fifteen women received a continuous oral dose of 2 m...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(97)01128-6
更新日期:1997-06-01 00:00:00
abstract::Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the as...
journal_title:Maturitas
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.maturitas.2018.03.004
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Osteoporotic vertebral fractures are associated with significant morbidity, excess mortality as well as health and social service expenditure. Additionally, women with a prevalent osteoporotic vertebral fracture have a high risk of experiencing a further one within one year. It is therefore important for t...
journal_title:Maturitas
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.maturitas.2014.03.002
更新日期:2014-06-01 00:00:00