Metabolic syndrome after menopause and the role of hormones.

Abstract:

OBJECTIVES:The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed. METHODS:Review of the relevant literature and results from recent clinical trials. RESULTS:MBS may occur in 40% of PM women and is largely determined by overweight status and obesity. Weight gain, particularly an increase in central fat mass increases in PM women, beginning a few years prior to menopause. Hormonal Therapy (HT) in normal PM women, generally decreases abdominal fat, but the effect of transdermal estrogen is preferable to oral therapy in this regard. In women with MBS, oral therapy was found to increase leptin and the leptin/adiponectin ratio, while transdermal therapy showed no changes. HT has been found to improve insulin resistance in PM women, although the data are mixed. In women with MBS, oral therapy was found to worsen parameters of insulin resistance, while transdermal therapy had minimal effects overall. Women with MBS have elevations in several inflammation and coagulation factors. Both oral and transdermal HT reduce inflammation markers except for levels of CRP and MMP-9, which increase with oral therapy, but are unaffected by the transdermal route. Oral estrogen has a small pro-coagulant effect, not observed with transdermal therapy, in both normal PM women and those with MBS. The beneficial effects of HT on lipids occur in PM women with and without MBS, although the changes in the latter are minimal. Blood pressure was not affected by HT in women with MBS. CONCLUSIONS:Weight gain and obesity largely drives the increased prevalence of MBS in PM women. Use of HT is beneficial overall for reducing many of the parameters of MBS. Our own data would suggest that in MBS, transdermal therapy may be preferable to oral therapy, at least in standard doses.

journal_name

Maturitas

journal_title

Maturitas

authors

Lobo RA

doi

10.1016/j.maturitas.2008.02.008

subject

Has Abstract

pub_date

2008-05-20 00:00:00

pages

10-8

issue

1

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(08)00039-X

journal_volume

60

pub_type

杂志文章,评审
  • Sexual function in menopausal women in Kelantan, Malaysia.

    abstract:OBJECTIVES:The aim of the study was to document sexual function in Kelantanese postmenopausal women. METHOD:A semi-structured questionnaire in Malay language was administered to 326 women (mean age of 57.1+/-6.58 (S.D.) years) residing in Kelantan. The subjects comprised of naturally menopaused, healthy women. RESULT...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2005.03.014

    authors: Dhillon HK,Singh HJ,Ghaffar NA

    更新日期:2005-11-01 00:00:00

  • Serum levels of oestrogens, progesterone, follicle-stimulating hormone and sex-hormone-binding globulin during simultaneous vaginal administration of 17 beta-oestradiol and progesterone in the pre- and post-menopause.

    abstract::Serum concentrations of 17 beta-oestradiol (E2), unconjugated oestrone (E1), total oestrone (tE1), progesterone (P), follicle-stimulating hormone (FSH) and sex-hormone-binding globulin (SHBG) were measured before and after daily intravaginal administration of 250 micrograms micronized E2 and 10 mg micronized P for 14 ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(88)90066-7

    authors: Carlström K,Pschera H,Lunell NO

    更新日期:1988-12-01 00:00:00

  • The mechanisms of thrombotic risk induced by hormone replacement therapy.

    abstract:OBJECTIVES:To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. RESULTS AND CONCLUSIONS:Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascu...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(01)00270-5

    authors: Cano A,Van Baal WM

    更新日期:2001-10-31 00:00:00

  • Treatment with percutanous testosterone gel in postmenopausal women with decreased libido--effects on sexuality and psychological general well-being.

    abstract:OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2005.01.002

    authors: Nathorst-Böös J,Flöter A,Jarkander-Rolff M,Carlström K,Schoultz Bv

    更新日期:2006-01-10 00:00:00

  • Bone turnover markers in statin users: a population-based analysis from the Camargo Cohort Study.

    abstract:OBJECTIVE:To analyze the effects of statin use on bone turnover markers (BTM), in participants from a large population-based cohort. SUBJECTS AND METHODS:Cross-sectional study that included 2431 subjects (1401 women and 930 men) from the Camargo Cohort. We analyzed the differences in serum BTM between statin or non-st...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.02.003

    authors: Hernández JL,Olmos JM,Romaña G,Martinez J,Castillo J,Yezerska I,Ramos C,González-Macías J

    更新日期:2013-05-01 00:00:00

  • Age-related changes in resting energy expenditure in normal weight, overweight and obese men and women.

    abstract:OBJECTIVES:Aging is associated with changes in resting energy expenditure (REE) and body composition. We investigated the association between age and changes in REE in men and women stratified by body mass index (BMI) categories (normal weight, overweight and obesity). We also examined whether the age-related decline i...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.12.023

    authors: Siervo M,Oggioni C,Lara J,Celis-Morales C,Mathers JC,Battezzati A,Leone A,Tagliabue A,Spadafranca A,Bertoli S

    更新日期:2015-04-01 00:00:00

  • Factors contributing to the variability in muscle ageing.

    abstract::Ageing is accompanied with a progressive loss of muscle mass and force generating capacity. Ultimately, the muscle wasting and weakness may dramatically impact on mobility and the quality of life, where the elderly has increasing problems with performing activities of daily life, such as rising from a chair or climbin...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2012.07.015

    authors: Degens H,Korhonen MT

    更新日期:2012-11-01 00:00:00

  • Prebiotics in the management of components of the metabolic syndrome.

    abstract::Components of the metabolic syndrome (MetS), including abdominal obesity, low-grade chronic systemic inflammation, altered glucose metabolism, dyslipidemia and high blood pressure, are major threats to healthy aging in modern societies. The connection between MetS components and gut microflora is now acknowledged and ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2017.07.005

    authors: O'Connor S,Chouinard-Castonguay S,Gagnon C,Rudkowska I

    更新日期:2017-10-01 00:00:00

  • Self-reported menopausal symptoms in a racially diverse population and soy food consumption.

    abstract:OBJECTIVES:Evaluate the association of self-reported vasomotor symptom (VMS) frequency with race/ethnicity among a diverse midlife US population and explore menopause symptom differences by dietary soy isoflavone (genistein+daidzein) consumption. STUDY DESIGN:Cross-sectional population-based study of peri- and postmen...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.03.003

    authors: Reed SD,Lampe JW,Qu C,Gundersen G,Fuller S,Copeland WK,Newton KM

    更新日期:2013-06-01 00:00:00

  • Neuropsychiatric aspects of dementia.

    abstract::Dementia affects approximately 6.5% of people over the age of 65. Whilst cognitive impairment is central to the dementia concept, neuropsychiatric symptoms are invariably present at some stage of the illness. Neuropsychiatric symptoms result in a number of negative outcomes for the individual and their caregivers and ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.04.005

    authors: Ford AH

    更新日期:2014-10-01 00:00:00

  • Menopause and aging: changes in the immune system--a review.

    abstract:BACKGROUND:The higher risk of women developing autoimmune diseases suggests that immune system is mediated by sex steroids. OBJECTIVE:To review the effects of aging and menopause in immune system. METHODS:A systematic review of in vitro, animal and human studies involving aging and menopause and immune system was car...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2010.08.003

    authors: Gameiro CM,Romão F,Castelo-Branco C

    更新日期:2010-12-01 00:00:00

  • Aromatherapy for stress reduction in healthy adults: a systematic review and meta-analysis of randomized clinical trials.

    abstract::The aim of this review was to systematically assess the effectiveness of aromatherapy for stress management. Seven databases were searched from their inception through April 2014. RCTs testing aromatherapy against any type of controls in healthy human person that assessed stress level and cortisol level were considere...

    journal_title:Maturitas

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.maturitas.2014.08.006

    authors: Hur MH,Song JA,Lee J,Lee MS

    更新日期:2014-12-01 00:00:00

  • Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women.

    abstract:BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0378-5122(95)00983-3

    authors: Piérard GE,Henry F,Piérard-Franchimont C

    更新日期:1996-04-01 00:00:00

  • Endocrinological and clinical investigations in post-menopausal women following administration of vaginal cream containing oestriol.

    abstract::The maturation value (MV), cervical mucus parameters (ferning, Spinnbarkeit), oestrone (E1), oestradiol (E2), oestriol (E3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyrotropin (TSH), growth hormone (GH), sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG) ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(81)90041-4

    authors: Haspels AA,Luisi M,Kicovic PM

    更新日期:1981-12-01 00:00:00

  • A 12-month randomized controlled trial of balance training in elderly women with osteoporosis: improvement of quality of life.

    abstract:OBJECTIVE:Physical and psychological incapacity, including fear of falling is related to decreased satisfaction with life in osteoporosis (OP). The impact of a balance exercise program on improving the quality of life is not well established. We have, therefore, investigated the effect of 12-month Balance Training Prog...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2010.03.009

    authors: Madureira MM,Bonfá E,Takayama L,Pereira RM

    更新日期:2010-06-01 00:00:00

  • Follicle culture after ovarian cryostorage.

    abstract:OBJECTIVES:Cryostorage of ovarian cortical tissue, before devastating chemo- and/or radiotherapy for cancer, permits survival of primordial and early preantral follicles. This work aims for a system allowing the long-term maturation in vitro (IVM) of small immature oocytes up to fertilisable metaphase II oocytes. METH...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(98)00071-1

    authors: Smitz J,Cortvrindt R

    更新日期:1998-10-12 00:00:00

  • A menopause-specific quality of life questionnaire: development and psychometric properties.

    abstract:OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(96)82006-8

    authors: Hilditch JR,Lewis J,Peter A,van Maris B,Ross A,Franssen E,Guyatt GH,Norton PG,Dunn E

    更新日期:1996-07-01 00:00:00

  • Does quitting smoking decrease the risk of midlife hot flashes? A longitudinal analysis.

    abstract::Epidemiological studies have shown that cigarette smoking is associated with an increased risk of midlife hot flashes; however, the effect of quitting smoking on this risk is unclear. The purpose of this study was to examine the effect of quitting smoking on hot flashes using data from 761 women aged 45 to 54 years of...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.06.029

    authors: Smith RL,Flaws JA,Gallicchio L

    更新日期:2015-09-01 00:00:00

  • Dose-dependent response of FSH, flushes and urinary calcium to oestrogen.

    abstract::The reduction of gonadotrophin levels, urinary calcium and hot flushes in post-menopausal patients by ethinyl oestradiol is shown to be dose dependent, near maximum response being achieved by a dose of 15 micrograms daily. Equivalent ethinyl oestradiol doses to a number of other gonadal hormone preparations have been ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(82)90060-3

    authors: Jones MM,Pearlman B,Marshall DH,Crilly RG,Nordin BE

    更新日期:1982-12-01 00:00:00

  • Dydrogesterone does not reverse the effects of estradiol on endothelium-dependant vasodilation in postmenopausal women: a randomised clinical trial.

    abstract:OBJECTIVES:The purpose of this study was to evaluate endothelium-dependent flow-mediated dilation (FMD) in the brachial artery and the plasma levels of endothelin-1 in postmenopausal women at risk for coronary artery disease before and after treatment with both estradiol and estradiol plus dydrogesterone. METHODS:Sixt...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(02)00184-6

    authors: Gambacciani M,Monteleone P,Vitale C,Silvestri A,Fini M,Genazzani AR,Rosano GM

    更新日期:2002-10-25 00:00:00

  • The role of clinical breast examination in cancer screening for women at average risk: A mini review.

    abstract::As the debate about the potential benefits and harms of screening mammography continues, it is timely to consider the role of clinical breast examination in screening for women at average risk of breast cancer. This article reviews the results from clinical trials and discusses the varied recommendations around the wo...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2016.07.011

    authors: Brennan ME

    更新日期:2016-10-01 00:00:00

  • Soy for the treatment of perimenopausal symptoms--a systematic review.

    abstract:OBJECTIVES:Many women have turned to complementary and alternative medicines for relief from their perimenopausal symptoms. The prevalence of plant-based medicine use among perimenopausal women highlights the need for investigation into these interventions. The aim of this study was to evaluate the benefit of soy prepa...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(03)00221-4

    authors: Huntley AL,Ernst E

    更新日期:2004-01-20 00:00:00

  • Vitamin D-related changes in intracranial volume in older adults: a quantitative neuroimaging study.

    abstract:OBJECTIVES:Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlatio...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.12.011

    authors: Annweiler C,Bartha R,Goncalves S,Karras SN,Millet P,Féron F,Beauchet O

    更新日期:2015-03-01 00:00:00

  • Gender differences in the incidence of and risk factors for hip fracture: A 16-year longitudinal study in a southern European population.

    abstract:OBJECTIVES:To analyze independently in men and women the incidence rate of and risk factors for hip fracture in a southern European population. Illiteracy, dementia, clinically significant depression and disability were factors to receive special emphasis. STUDY DESIGN:A community sample of 4803 individuals aged over ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2016.12.009

    authors: Lobo E,Marcos G,Santabárbara J,Salvador-Rosés H,Lobo-Escolar L,De la Cámara C,Aso A,Lobo-Escolar A,ZARADEMP Workgroup.

    更新日期:2017-03-01 00:00:00

  • The effect of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats.

    abstract:OBJECTIVE:The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. METHODS:Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiti...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00068-3

    authors: Kuşcu NK,Koyuncu FM,Inan S,Tuglu I,Uyar Y,Ozbilgin K

    更新日期:2002-07-25 00:00:00

  • Serum estrogen level after hormone replacement therapy and body mass index in postmenopausal and bilaterally ovariectomized women.

    abstract:OBJECTIVE:The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. METHODS:Eighty-six postmenopausal and 51 bilaterally ovariectomized ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2004.03.013

    authors: Yasui T,Uemura H,Umino Y,Takikawa M,Saito S,Kuwahara A,Matsuzaki T,Maegawa M,Furumoto H,Miura M,Irahara M

    更新日期:2005-01-10 00:00:00

  • Motives for initiation, temporary discontinuation, and permanent discontinuation of hormone replacement therapy use among Norwegian women.

    abstract:OBJECTIVE:The use of hormone replacement therapy (HRT) declined strongly in many countries after publication of the WHI-study. The purpose of the present study was to investigate HRT usage patterns and motives for initiation, temporary discontinuation, and permanent discontinuation of HRT use among Norwegian women. ME...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2009.07.010

    authors: Øren A

    更新日期:2009-09-20 00:00:00

  • New therapeutic targets for osteoporosis: beyond denosumab.

    abstract::Treatments for osteoporosis over the last few decades have largely focused on antiresorptive agents that effectively prevent bone loss. Beginning with hormone therapy, a variety of new potent antiresorptive agents were developed, including oral and intravenous bisphosphonates, raloxifene and other selective estrogen r...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2012.08.002

    authors: Lim V,Clarke BL

    更新日期:2012-11-01 00:00:00

  • The age and symptomatology of natural menopause among United Arab Emirates women.

    abstract:OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(98)00010-3

    authors: Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

    更新日期:1998-06-17 00:00:00

  • Hormonal replacement regimens and bleeding.

    abstract::Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossibl...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(99)00069-9

    authors: Dören M

    更新日期:2000-01-01 00:00:00