Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women.

Abstract:

OBJECTIVES:To investigate the effect of estrogen alone or combined with progestin on the amount and synthesis of skin collagen in postmenopausal women. METHODS:Forty-three early postmenopausal women were enrolled into this open, non-randomized parallel-groups study. Fifteen women received a continuous oral dose of 2 mg of 17 beta-estradiol and 1 mg of norethisterone acetate daily and 14 women an oral dose of 2 mg estradiol valerate daily. Fourteen subjects served as controls. The histology and type I and III procollagen immunohistochemistry of the skin, skin thickness, the amount of total collagen determined by a colorimetric method and the synthesis of type I and III collagens determined by analysing procollagen propeptides in the suction blister fluid were studied before the treatment and at 6 and 12 months. The proportional area of elastic fibers and the thickness of the epidermis were assessed from the sections obtained before the treatment and at 12 months, with computerized image analysis. RESULTS:Skin thickness, the amount and rate of collagen synthesis, the proportional area of elastic fibers and the thickness of the epidermis were not affected by either 17 beta-estradiol and 1 mg of norethisterone acetate or 2 mg of estradiol valerate. No histological or immunohistological changes were detected in the skin specimens during the 12-month treatment period compared to the baseline or to the skin specimens of the control group. CONCLUSIONS:A 1-year treatment with systemic estrogen alone or combined with progestin does not change the amount of collagen or the rate of collagen synthesis in postmenopausal women.

journal_name

Maturitas

journal_title

Maturitas

authors

Haapasaari KM,Raudaskoski T,Kallioinen M,Suvanto-Luukkonen E,Kauppila A,Läärä E,Risteli J,Oikarinen A

doi

10.1016/s0378-5122(97)01128-6

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

153-62

issue

2

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(97)01128-6

journal_volume

27

pub_type

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