Abstract：
:The effect of estradiol valerate (Progynova, 2 mg daily) on the renin--aldosterone system was studied in nine women after bilateral oophorectomy. Plasma renin activity (PRA) and the daily urinary excretion of aldosterone (dU-Ald) were determined 4 mth after the operation -- during which no estrogen was given -- and after 3 mth on estrogen therapy. Plasma estradiol concentration rose in 7 subjects to the normal postovulatory level. No changes were found in PRA or dU-Ald. The results suggest that an effective estradiol valerate therapy is not accompanied with activation of renin--aldosterone system, while synthetic and non-human natural estrogens (Premarin) were shown earlier to increase PRA.
journal_name
Maturitasjournal_title
Maturitasauthors
Punnonen R,Lammintausta R,Erkkola R,Rauramo Ldoi
10.1016/0378-5122(80)90041-9subject
Has Abstractpub_date
1980-07-01 00:00:00pages
91-4issue
2eissn
0378-5122issn
1873-4111journal_volume
2pub_type
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