Abstract：
:The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continuously on the recumbent subject during the 2-h test. None of the women reacted either subjectively or objectively to the placebo. TRH induced gastric pain in 1 post-menopausal subject. In another subject TRH elicited no response during the first test, but a week later in a second test it evoked transient nausea and a series of hot flashes with bursts of sweating. Published results of animal studies suggest that a higher dose of TRH would probably stimulate hot flash-like responses in more women.
journal_name
Maturitasjournal_title
Maturitasauthors
Molnar GWdoi
10.1016/0378-5122(81)90003-7subject
Has Abstractpub_date
1981-08-01 00:00:00pages
115-23issue
2eissn
0378-5122issn
1873-4111pii
0378-5122(81)90003-7journal_volume
3pub_type
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