Abstract:
OBJECTIVE:the aim of this study was to evaluate the influence of serum leptin concentration on bone mass assessed by quantitative ultrasound (QUS) in a large sample of healthy pre and postmenopausal women. DESIGN:555 healthy pre and postmenopausal (n=261 and n=294) women (mean age, 49.5+/-17.2 years) not on hormone replacement therapy were recruited on the occasion of a routine gynecological visit. Before entry to the study, all women had answered a detailed questionnaire on important risk factors and gave written informed consent. Speed of sound (SOS), broadband ultrasound attenuation (BUA) and stiffness index (SI) of the os Calcis were measured using the Achilles ultrasonometer (GE/lunar). We systematically investigated the relation of menopause, BMI and leptin on bone mass by allocating women into the following groups: (a) premenopausal women BMI<25 kg/m(2) (N=178); (b) premenopausal women BMI>25 kg/m(2) (N=83); (c) postmenopausal women BMI<25 kg/m(2) (N=125); and (d) postmenopausal women BMI>25 kg/m(2) (N=169). Additionally we investigated the relation of serum leptin concentrations, age and BMI on ultrasonometry variables by performing a multiple linear regression analyses. RESULTS:in the initial analyses premenopausal women showed a significantly (P<0.001) lower mean age, weight, BMI, follicle stimulating hormone (FSH) and leptin concentration, a higher mean height, serum estradiol and ultrasonometry variables in comparison to postmenopausal women. Irrespective of the menopausal status, women with a BMI>25 kg/m(2) had significantly higher leptin concentrations (P<0.001) and BUA (P<0.05) whereas SOS and SI was not significant different, compared to women with a BMI<25 kg/m(2). The multiple linear regression analyses showed that only BMI but not Leptin was related to higher ultrasonometry variables, whereas increasing age was associated with a decrease in ultrasonometry variables. Furthermore, the multiple linear regression analyses confirmed that age and BMI were the only statistically significant independent predictor for ultrasonometry variables. There was no significant influence of leptin on ultrasonometry variables even after controlling for BMI or age, or BMI and age. CONCLUSIONS:serum leptin concentrations are significantly higher in pre and postmenopausal obese women, compared with normal weight controls. Ultrasonometry variables are influenced by age and BMI but not by serum leptin concentrations.
journal_name
Maturitasjournal_title
Maturitasauthors
Hadji P,Bock K,Gotschalk M,Hars O,Backhus J,Emons G,Schulz KDdoi
10.1016/s0378-5122(02)00324-9keywords:
subject
Has Abstractpub_date
2003-02-25 00:00:00pages
141-8issue
2eissn
0378-5122issn
1873-4111pii
S0378512202003249journal_volume
44pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVES:Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this internation...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.maturitas.2003.12.012
更新日期:2004-07-15 00:00:00
abstract::The aim of the study was to investigate the influence of long-term administration of oral contraceptives on bone density in climacteric women. The existence of a correlation between long-term use and bone density was confirmed. ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(88)90103-x
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVE:To determine the percentage of endometrial hyperplasia positive for p53 expression in both spontaneously occurring cases or following the use of unopposed estradiol. METHODS:Fifty-four postmenopausal patients with endometrial hyperplasia diagnosed by endometrial biopsy and hysteroscopy were recruited to this...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00326-2
更新日期:2003-03-28 00:00:00
abstract:OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.01.013
更新日期:2006-09-20 00:00:00
abstract:OBJECTIVES:To examine Chinese middle-aged women's health and wellbeing and the associated biosocial correlates. STUDY DESIGN:This study used a cross-sectional design, including selected retrospectively collected information on the final menstrual period, drawn from the 2013 wave of the China Health and Retirement Long...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.10.008
更新日期:2021-01-01 00:00:00
abstract::In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00010-5
更新日期:2002-04-15 00:00:00
abstract::Vulvodynia, defined as vulvar pain or burning sensation for more than 3 months, without an identifiable cause, can occur at any age. In this paper, the authors address the classification, epidemiology, etiology, diagnosis, and treatment of this condition, focusing on postmenopausal women. In postmenopausal women, vulv...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2017.11.003
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of estrogen alone or combined with progestin on the amount and synthesis of skin collagen in postmenopausal women. METHODS:Forty-three early postmenopausal women were enrolled into this open, non-randomized parallel-groups study. Fifteen women received a continuous oral dose of 2 m...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(97)01128-6
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:It has become popular to assert that Asian women in general have low midlife rates of reporting a wide variety of symptoms and that these rates are much lower than those found among women in western countries. Comparable data from mainland China remains sparse, however. This study aimed to uncover the sympto...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.12.010
更新日期:2006-08-20 00:00:00
abstract::As increasing numbers of individuals reach very advanced age, it is important to understand the influence of modifiable lifestyle factors such as diet and nutrition on both the achievement of exceptional longevity as well as the maintenance of optimal functional capacity. This includes determining the most appropriate...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.12.002
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:This study examined factors associated with self-reported physical and mental health, focusing on caregiving status and the availability of social supports and financial resources. METHODS:Two bivariate analyses were performed to examine the sociodemographic characteristics as well as perceived health outco...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Vitamin D receptor (VDR) gene polymorphisms and the risks for various breast and ovarian cancers have been reported in many epidemiological studies. However, the associations between VDR gene polymorphisms and the risk for each type of cancer are unclear. The aim of this meta-analysis was to evaluate the associations ...
journal_title:Maturitas
pub_type: 杂志文章,meta分析
doi:10.1016/j.maturitas.2015.03.010
更新日期:2015-06-01 00:00:00
abstract::Menopause marks a time of dramatic hormonal and often social change for women. Both risk factors and health needs are likely to change as women pass through menopause. This paper examines the demographic characteristics of the world population of menopausal and post-menopausal women, and also examines the implication ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(95)00968-x
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00247-0
更新日期:2004-02-20 00:00:00
abstract::In 23 post-menopausal women, serum levels of cortisol, unconjugated dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS), testosterone, unconjugated and total oestrone and prolactin were measured before and during an ACTH test. Significant positive correlations were found between basal levels of DHA an...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(82)90037-8
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:To measure climacteric symptoms in a population-based survey as assessed by the Greene Climacteric Scale and to obtain normative data for the total score and subscales (psychological, somatic, vasomotor, and sexual) of the Greene Climacteric Scale. METHODS:A sample representative of the Dutch female populati...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00212-7
更新日期:2001-04-20 00:00:00
abstract:OBJECTIVE:In this study we aimed to pilot test the hypothesis that in women who are severely bothered by their menopausal complaints, improvement of menopausal symptoms is associated with an improvement in self-perceived work ability. STUDY DESIGN:This retrospective cohort study assessed the work ability of first-time...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.10.015
更新日期:2019-02-01 00:00:00
abstract::Earlier menopause onset has been linked to a greater risk of cardiovascular disease. Both menopause onset and cardiovascular disease risk vary by geographical region, race/ethnicity and socioeconomic status. As such, it is plausible to hypothesize that these factors may influence the association of menopause onset and...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2020.06.007
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Social support interventions for caregivers of persons with dementia (PwD) are important because informal carers often rely on their social networks for support. This systematic review synthesises findings from research on social support interventions, and examines their methodological quality and effectivene...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.12.008
更新日期:2016-03-01 00:00:00
abstract::Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(94)00855-2
更新日期:1995-01-01 00:00:00
abstract::For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.05.015
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To investigate if women with a history of having experienced intimate partner violence (IPV) who undertook caregiving would experience worse mental and physical health compared to those without caregiving roles. STUDY DESIGN AND MAIN OUTCOME MEASURES:IPV, caregiving history and data on covariates were colle...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.05.001
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:An internet survey was performed to obtain data on the current use in Belgium of hormone replacement therapy and alternative treatments for the alleviation of menopausal symptoms. A supplementary aim was to assess the use of opt-in internet opinion panels (TalkToChange, http://www.talktochange.com, and GMI, ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.04.018
更新日期:2016-08-01 00:00:00
abstract::With ageing populations a major challenge is to maintain physical and cognitive function, quality of life and independence. The literature does not only indicate important gender differences in lifestyle behaviours, but also how these behaviours might affect health outcomes. The current review has a male perspective w...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2013.02.011
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of hormone therapy (HT) administered to postmenopausal women on pulmonary function tests (PFT). METHODS:Eighty-two postmenopausal women who were having natural or surgically initiated menopause and had no risk factor that could affect the respiratory system were included into this ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2004.01.009
更新日期:2004-11-15 00:00:00
abstract::In a population-based prospective study it was shown that weight, height, overweight, total body size, age at first birth, parity and age at menopause are risk factors for the development of endometrial cancer. The finding that the patients had had a higher oestrogen excretion level than the controls some time before ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(85)90036-2
更新日期:1985-05-01 00:00:00
abstract::While the benefits of progestins in hormonal replacement therapy are well recognized as far as endometrial protection is concerned the data on breast tissue and the cardiovascular system are contentious. Following the Women's Health Initiative study, the Million Women Study and The Women's International Study of Long-...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2008.12.019
更新日期:2009-04-20 00:00:00
abstract::Since the launch in 2008 by the National Osteoporosis Guideline Group (NOGG), of guidance for the diagnosis and management of osteoporosis in postmenopausal women and older men in the UK there have been significant advances in risk assessment and treatment. These have been incorporated into an updated version of the g...
journal_title:Maturitas
pub_type: 杂志文章,实务指引
doi:10.1016/j.maturitas.2013.05.013
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. STUDY DESIGN:This was a single-blind randomi...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2019.10.014
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Evaluate the association of self-reported vasomotor symptom (VMS) frequency with race/ethnicity among a diverse midlife US population and explore menopause symptom differences by dietary soy isoflavone (genistein+daidzein) consumption. STUDY DESIGN:Cross-sectional population-based study of peri- and postmen...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.03.003
更新日期:2013-06-01 00:00:00