Abstract：
OBJECTIVE:To determine the percentage of endometrial hyperplasia positive for p53 expression in both spontaneously occurring cases or following the use of unopposed estradiol. METHODS:Fifty-four postmenopausal patients with endometrial hyperplasia diagnosed by endometrial biopsy and hysteroscopy were recruited to this study. Thirty-three patients had used unopposed estradiol for periods of time from 1 to 3 years. P53 expression was detected in paraffin-embedded endometrial specimens by immunohistochemical methods. RESULTS:The percentage of endometrial hyperplasia positive for p53 expression was significantly greater in spontaneously occurring hyperplasia than in cases induced by the unopposed use of estradiol. CONCLUSION:Endometrial hyperplasia caused by the unopposed use of estradiol during menopause probably harbors fewer genomic errors than those cases occurring spontaneously.
journal_name
Maturitasjournal_title
Maturitasauthors
Maia H Jr,Maltez A,Athayde C,Coelho G,Coutinho EMdoi
10.1016/s0378-5122(02)00326-2keywords:
subject
Has Abstractpub_date
2003-03-28 00:00:00pages
175-80issue
3eissn
0378-5122issn
1873-4111pii
S0378512202003262journal_volume
44pub_type
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