Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing.

abstract：:The menopausal syndrome is characterized by a variety of emotional and physical symptoms of varying intensity. A total of 1287 women who attended the Outpatient Department for Climacteric Symptoms and Osteoporosis Prophylaxis (1st Department of Gynaecology and Obstetrics, University of Vienna Medical School) constitut...

journal_title：Maturitas

authors： Metka M,Enzelsberger H,Knogler W,Schurz B,Aichmair H

更新日期：1991-12-01 00:00:00

abstract：:Heart disease is a major cause of death, disease and disability in the developed world for both men and women. Women appear to be under-diagnosed and treated both because they fail to visit the doctor or hospital with relevant symptoms and because doctors tend to dismiss the seriousness of women's symptoms of heart di...

journal_title：Maturitas

authors： Clarke J

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to evaluate the effects of low doses of hormone replacement therapy (HRT) in normal young postmenopausal women. METHODS:In an open trial healthy, non-obese postmenopausal women received for 2 years a low-dose continuous combined HRT (LD-HRT) containing 1mg estradiol+0.5 mg n...

journal_title：Maturitas

authors： Gambacciani M,Cappagli B,Ciaponi M,Pepe A,Vacca F,Genazzani AR

更新日期：2008-01-20 00:00:00

abstract：OBJECTIVE:Deficiency of the gene encoding endothelial nitric oxide synthase, i.e. Nos3, has been reported to be associated with late menarche, reduced ovulation rates, fewer deliveries, and earlier onset of menopause in a mouse model. METHODS:We assessed the Glu298Asp and the T-786C polymorphisms of Nos3 in 87 consecu...

journal_title：Maturitas

authors： Worda C,Walch K,Sator M,Eppel W,Tempfer CB,Schneeberger C,Huber JC,Hefler LA

更新日期：2004-10-15 00:00:00

abstract：:Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...

journal_title：Maturitas

authors： Liedtke C,Kiesel L

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...

journal_title：Maturitas

authors： Karjalainen AH,Ruskoaho H,Vuolteenaho O,Heikkinen JE,Bäckström AC,Savolainen MJ,Kesäniemi YA

更新日期：2004-03-15 00:00:00

abstract：INTRODUCTION:The use of menopausal hormone therapy (MHT) has decreased in many countries in the past 10 years. This is a consequence of the initial publication of the results of the Women's Health Initiative (WHI) randomized trial of estrogen plus progestin. In various countries, further studies then analyzed the incid...

journal_title：Maturitas

authors： Antoine C,Ameye L,Paesmans M,de Azambuja E,Rozenberg S

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS:In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die ...

journal_title：Maturitas

authors： Marchesoni D,Driul L,Ianni A,Fabiani G,Della Martina M,Zuiani C,Bazzocchi M

更新日期：2006-01-10 00:00:00

abstract：:Osteoarthritis (OA) is a common age-related disease that affects the tissues of the synovial joint, leading to loss of function and pain. It impacts on both patient morbidity and mortality. It is a complex, polygenic disease that lacks any large-effect susceptibility loci. Instead, OA susceptibility alleles individual...

journal_title：Maturitas

authors： Reynard LN,Loughlin J

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055. METHODS:Between May 1999 and December 2001, we accrued 136 breast cancer survivors aged 35-5...

journal_title：Maturitas

authors： Hernández Muñoz G,Pluchino S

更新日期：2003-03-14 00:00:00

abstract：OBJECTIVES:To link the Menopause Rating Scale (MRS-II) to the International Classification of Functioning, Disability and Health (ICF) and present a clinical application of an ICF-based tool. STUDY DESIGN:The MRS-II was linked to the corresponding ICF category. The linked items were used to generate an ICF Categorical...

journal_title：Maturitas

authors： Zangger M,Poethig D,Meissner F,von Wolff M,Stute P

更新日期：2018-12-01 00:00:00

abstract：:The clinical profile of Org OD 14 ((7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5 (10)-en-20-yn-3-one) is remarkable in that the compound demonstrates simultaneous weak oestrogenic, androgenic and progestational activity after oral administration to animals. It was therefore studied to evaluate its efficacy in t...

journal_title：Maturitas

authors： Tax L,Goorissen EM,Kicovic PM

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Alterations in sleep quality and metabolism during menopause are improved by menopausal hormone therapy (MHT). The mechanisms mediating these effects remain unclear. Orexin A (OxA) is a neuro-peptide that regulates sleep/wakefulness, food intake and metabolism. This study examined changes in plasma OxA levels...

journal_title：Maturitas

authors： Cintron D,Beckman JP,Bailey KR,Lahr BD,Jayachandran M,Miller VM

更新日期：2017-05-01 00:00:00

abstract：:Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all pati...

journal_title：Maturitas

authors： Andersson KE,Abdel-Hamid IA

更新日期：2011-09-01 00:00:00

abstract：:From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 1...

journal_title：Maturitas

authors： Rannevik G,Jeppsson S,Johnell O,Bjerre B,Laurell-Borulf Y,Svanberg L

更新日期：2008-09-01 00:00:00

abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...

journal_title：Maturitas

authors： Nedstrand E,Ekseth U,Lindgren R,Hammar M

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN:Cross-secti...

journal_title：Maturitas

authors： Palma F,Xholli A,Cagnacci A,as the writing group of the AGATA study.

更新日期：2018-02-01 00:00:00

abstract：:In Western countries, cardiovascular disease is the leading cause of death in women. Prevalence of risk factors and clinical presentation are different in men and women and it is important to take these differences into account in both prevention and treatment. A healthy diet can substantially reduce cardiovascular ri...

journal_title：Maturitas

authors： Hoekstra T,Beulens JW,van der Schouw YT

更新日期：2009-05-20 00:00:00

abstract：:The occurrence of uterine bleeding usually associated with hormonal replacement therapy is not acceptable for many women. Our objective was to review data on compliance and bleeding patterns in 70 postmenopausal women on oral replacement with estradiol 2 mg, estriol 1 mg, and norethisterone acetate 1 mg daily administ...

journal_title：Maturitas

authors： Dören M,Schneider HP

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this review is to summarize the effectiveness of select vitamins, minerals and trace elements in postmenopausal women for their effects on bone health, cardiovascular health, breast cancer, cognition and vasomotor symptoms. METHODS:Review of the relevant literature and results from recent cli...

journal_title：Maturitas

authors： Dennehy C,Tsourounis C

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer screening (OCS) for BRCA1/2 mutation carriers was stopped in our family cancer clinic in 2009 because of its ineffectiveness. The study objective was to investigate the effect of stopping OCS on the timing and uptake of risk-reducing salpingo-oophorectomy (RRSO) and on the percentage of occult ...

journal_title：Maturitas

authors： van Driel CM,de Bock GH,Arts HJ,Sie AS,Hollema H,Oosterwijk JC,Mourits MJ

更新日期：2015-03-01 00:00:00

abstract：:Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal...

journal_title：Maturitas

authors： Brincat M,Versi E,O'Dowd T,Moniz CF,Magos A,Kabalan S,Studd JW

更新日期：1987-04-01 00:00:00

abstract：:Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease hi...

journal_title：Maturitas

authors： Langston JP,Carson CC 3rd

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Studies focusing on lifestyle and health factors and stress urinary incontinence (SUI) are scarce in Japan. The aim of this study is to examine the association of lifestyle and health factors in SUI. METHODS:Study subjects were retrieved from Japanese women participating in a health checkup program provided...

journal_title：Maturitas

authors： Masue T,Wada K,Nagata C,Deguchi T,Hayashi M,Takeda N,Yasuda K

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To re-examine the minimal effective dose of conjugated estrogen (CEE)-progestin hormone replacement on postmenopausal bone loss. DESIGN:A 2-year, prospective, open label, randomized study. SETTING:Department of Obstetrics and Gynecology of a university hospital. PARTICIPANTS:Fifty-two postmenopausal or oop...

journal_title：Maturitas

authors： Mizunuma H,Okano H,Soda M,Kagami I,Miyamoto S,Tokizawa T,Honjo S,Ibuki Y

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

journal_title：Maturitas

authors： Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

更新日期：1998-06-17 00:00:00

abstract：OBJECTIVE:The aim of this prospective 3-year clinical study was to examine the effect of hormone replacement therapy (HRT) on uterine fibroid growth among postmenopausal women. METHODS:Thirty-seven postmenopausal women with uterine solitary fibroids were recruited randomly for HRT in a 3-year program. All participants...

journal_title：Maturitas

authors： Yang CH,Lee JN,Hsu SC,Kuo CH,Tsai EM

更新日期：2002-09-30 00:00:00

abstract：OBJECTIVE:Given the asymptomatic nature of osteoporosis, a fragility fracture provides an opportunity to make the issue of osteoporosis relevant to patients. Patients who link their fragility fracture with osteoporosis are more likely to initiate osteoporosis treatment, yet to date, we know little about who is likely t...

journal_title：Maturitas

authors： Sujic R,Gignac MA,Cockerill R,Beaton DE

更新日期：2013-10-01 00:00:00

abstract：:The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD...

journal_title：Maturitas

authors： Kuol N,Stojanovska L,Nurgali K,Apostolopoulos V

更新日期：2017-11-01 00:00:00

abstract：:The effect of two forms of exogenous estrogen and a placebo on diastolic blood pressure and bodyweight was evaluated in 50 oophorectomized women. There was no significant change in bodyweight on any form of treatment, nor was there any significant elevation in mean diastolic blood pressure. However, 2 out of 49 female...

journal_title：Maturitas

authors： Utian WH

更新日期：1978-06-01 00:00:00