Prevention of postmenopausal bone loss with minimal uterine bleeding using low dose continuous estrogen/progestin therapy: a 2-year prospective study.

Abstract:

OBJECTIVE:To re-examine the minimal effective dose of conjugated estrogen (CEE)-progestin hormone replacement on postmenopausal bone loss. DESIGN:A 2-year, prospective, open label, randomized study. SETTING:Department of Obstetrics and Gynecology of a university hospital. PARTICIPANTS:Fifty-two postmenopausal or oophorectomized women. INTERVENTION:One of the following regimens was continuously administered for 2 years: (1) CEE 0.625 mg/day, (2) CEE 0.625 mg + medroxyprogesterone (MPA) 2.5 mg/day, (3) CEE 0.31 mg + MPA 2.5 mg/day and (4) control. MEASUREMENTS:Lumbar spine and femoral BMD by dual energy X-ray absorptiometry (DXA), a monthly based incidence of bleeding, serum lipids, PTH, calcitonin. A1-p, and osteocalcin. RESULTS:Of the 52 patients enrolled in this study, 49 patients completed the 1 year of therapy and 36 completed the 2- year study. The control group showed a significant decrease in lumbar BMD over the 2 years (P < 0.05). The % changes in lumbar BMD at 2 years of CEE alone, CEE 0.625 + MPA and CEE 0.31 + MPA were 8.52% (95% confidence intervals; 4.61 approximately 12.4%), 7.4% (0.60 approximately 14.2%) and 3.20% (0.61 approximately 5.84%), respectively, and were significantly higher than pretreatment values. The incidence of bleeding was significantly lower in women taking CEE 0.31 mg + MPA. HDL cholesterol increased in women taking CEE 0.625 mg alone or with MPA. No significant changes in lipid profiles were seen in the control or in the group of women taking CEE 0.31 mg + MPA. CONCLUSIONS:Continuous hormone replacement therapy (HRT) using 0.31 mg of CEE and 2.5 mg of MPA is effective in increasing lumbar BMD in postmenopausal or oophorectomized women and can be an appropriate option for women with a normal lipid profile or those women wishing to eliminate unscheduled bleeding.

journal_name

Maturitas

journal_title

Maturitas

authors

Mizunuma H,Okano H,Soda M,Kagami I,Miyamoto S,Tokizawa T,Honjo S,Ibuki Y

doi

10.1016/s0378-5122(97)01110-9

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

69-76

issue

1

eissn

0378-5122

issn

1873-4111

pii

S0378512297011109

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
  • Coronary heart disease in menopausal women: implications of primary and secondary prevention trials of hormones.

    abstract::In direct contrast to the observational studies, both primary and secondary prevention trials of female reproductive hormones have found no benefit for coronary heart disease (CHD). Basic science studies have elucidated several mechanisms by which estrogen may improve coronary arterial physiology and prevent pathology...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2005.02.015

    authors: Rossouw JE

    更新日期:2005-05-16 00:00:00

  • Comparative effects of risedronate, atorvastatin, estrogen and SERMs on bone mass and strength in ovariectomized rats.

    abstract:OBJECTIVE:The aim of this study was to investigate bone protective effects of risedronate, atorvastatin, raloxifene and clomiphene citrate in ovariectomized rats. METHODS:Our study was conducted on 63 rats at Experimental Research Center of Celal Bayar University. Six-month-old rats were divided into seven groups. The...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2009.03.018

    authors: Uyar Y,Baytur Y,Inceboz U,Demir BC,Gumuser G,Ozbilgin K

    更新日期:2009-07-20 00:00:00

  • The influence of hormone replacement therapy on skin ageing: a pilot study.

    abstract:OBJECTIVES:We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, trans...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(00)00225-5

    authors: Sator PG,Schmidt JB,Sator MO,Huber JC,Hönigsmann H

    更新日期:2001-07-25 00:00:00

  • Hormonal replacement therapy and the skeletal system.

    abstract::The two most important risk factors for maintaining skeletal health are the bone mass obtained at skeletal maturity (peak bone mass) and the subsequent bone loss. Those women with a low peak bone mass and a rapid bone loss are thus at increased risk of developing osteoporosis in the future, and should be identified. T...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(90)90006-r

    authors: Christiansen C,Riis BJ

    更新日期:1990-09-01 00:00:00

  • Depression and the incidence of urinary incontinence symptoms among young women: Results from a prospective cohort study.

    abstract:OBJECTIVE:To examine the association of depressive symptoms with subsequent urinary incontinence (UI) symptoms among young women. SUBJECTS AND METHODS:Data were from a cohort of 5391 young women (born 1973-1978) from the Australian Longitudinal Study on Women's Health. Generalised Estimating Equations (GEEs) were used...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.05.006

    authors: Mishra GD,Barker MS,Herber-Gast GC,Hillard T

    更新日期:2015-08-01 00:00:00

  • Shared decision-making in the context of menopausal health: where do we stand?

    abstract::Most health decisions occur in contexts of scientific uncertainty, the "grey zone" of decision-making and many decisions faced by menopausal women are no exception. These contexts are characterized either by scientific evidence that points to a balance between harms and benefits within or between options, or by the ab...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.01.013

    authors: Légaré F,Brouillette MH

    更新日期:2009-07-20 00:00:00

  • Hormone replacement therapy: the benefits in tailoring the regimen and dose.

    abstract::Despite the clear benefits of long-term hormone replacement therapy (HRT), the majority of patients tend to undergo short-term treatment. The cyclical bleedings induced by the sequential progestogen administration are often unacceptable namely in the elderly postmenopausal women. At the standard doses HRT preparations...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(01)00281-x

    authors: Gambacciani M,Genazzani AR

    更新日期:2001-12-14 00:00:00

  • Bone metabolism regulators and arterial stiffness in postmenopausal women.

    abstract:BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.07.001

    authors: Albu A,Fodor D,Bondor C,Crăciun AM

    更新日期:2013-10-01 00:00:00

  • Cardiovascular risk factors in a cohort of Danish women born in 1936 prior to use of hormone therapy.

    abstract:OBJECTIVE:Many observational studies suggest hormone therapy protects against coronary heart disease in contrast to findings from large randomised clinical trials and an observational Danish study. A potential bias in the observational literature concerning the cardiovascular risk and benefits associated with use of ho...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2004.05.011

    authors: Løkkegaard E,Eplov LF,Køster A,Garde K

    更新日期:2005-07-16 00:00:00

  • Conjugated estrogen/progestagen versus tibolone hormone replacement therapy in postmenopausal women: Effects on carbohydrate metabolism and serum sex hormone-binding globulin.

    abstract:OBJECTIVE:To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism. METHOD:Postmenopausal women were treated with conjugated estrogens, 0.625 mg/medroxyprogesterone acetate, 2.5 or 5 mg (CEE/MPA) or tibolone 2.5 mg daily for 13 28-day cycles. Serum glucose and insuli...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.maturitas.2005.03.003

    authors: Odmark IS,Carlström K,Jonsson B,Jonasson AF

    更新日期:2006-01-10 00:00:00

  • Tibolone: a review.

    abstract::Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(98)00059-0

    authors: Albertazzi P,Di Micco R,Zanardi E

    更新日期:1998-11-16 00:00:00

  • Hormone replacement therapy in postmenopausal women with specific risk factors for coronary artery disease.

    abstract::Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(98)00056-5

    authors: van der Mooren MJ,Mijatovic V,van Baal WM,Stehouwer CD

    更新日期:1998-09-20 00:00:00

  • Vulvostomatodynia.

    abstract::Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital sympt...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.05.003

    authors: Petruzzi M,De Benedittis M,Pastore L,Serpico R

    更新日期:2007-09-20 00:00:00

  • Facial wrinkling in postmenopausal women. Effects of smoking status and hormone replacement therapy.

    abstract:BACKGROUND:There is some evidence that hormone replacement therapy may produce significant improvements in fine wrinkling, while aging skin is more frequently found in smokers. However, studies of the combined effect of a protective factor, such as HRT, and a damaging factor, such as smoking, are rare. OBJECTIVES:To d...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0378-5122(97)00087-x

    authors: Castelo-Branco C,Figueras F,Martínez de Osaba MJ,Vanrell JA

    更新日期:1998-05-20 00:00:00

  • Temporal trends in sitting time by domain in a cohort of mid-age Australian men and women.

    abstract::There are few prospective data on temporal trends in overall sitting time for different domains of sitting. This study examined time trends over 6 years in total and domain-specific sitting time in mid-age Australian men and women. Self-report data from 5246 participants in four survey waves (2007, 2009, 2011, 2013) o...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2018.08.006

    authors: Mielke GI,Burton NW,Turrell G,Brown WJ

    更新日期:2018-10-01 00:00:00

  • Association of the osteoprotegerin gene polymorphisms with bone mineral density in postmenopausal women.

    abstract:OBJECTIVES:Osteoprotegerin (OPG) is a recently discovered member of the tumour necrosis factor receptor superfamily. It plays a crucial role in the control of bone resorption and its gene could therefore be a good candidate gene for osteoporosis. The aim of our work was to find polymorphisms in the OPG gene and to inve...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2004.08.006

    authors: Arko B,Prezelj J,Kocijancic A,Komel R,Marc J

    更新日期:2005-07-16 00:00:00

  • Gender paradox in cardiac calcium deposits in middle-aged and elderly patients: mitral annular and coronary calcifications interrelationship.

    abstract:OBJECTIVES:mitral annular calcification (MAC) occurs mainly in middle-aged and elderly patients and can lead to serious clinical consequences. Male predominance in the prevalence of coronary disease is well-established. Paradoxically, the prevalence of MAC, which is theoretically based on the same etiological mechanism...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(00)00120-1

    authors: Tenenbaum A,Fisman EZ,Pines A,Shemesh J,Shapira I,Adler Y,Frenkel Y,Boyko V,Motro M

    更新日期:2000-07-31 00:00:00

  • Effect of hormone replacement therapy on lipids in perimenopausal and early postmenopausal women.

    abstract:OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(01)00224-9

    authors: Ossewaarde ME,Bots ML,Bak AA,Van Der Schouw YT,Witteman JC,Planellas J,Bennink HJ,Grobbee DE

    更新日期:2001-09-28 00:00:00

  • Quality of life among postmenopausal Ecuadorian women participating in a metabolic syndrome screening program.

    abstract:BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.05.008

    authors: Chedraui P,Hidalgo L,Chavez D,Morocho N,Alvarado M,Huc A

    更新日期:2007-01-20 00:00:00

  • The health pros and cons of continuous versus intermittent calorie restriction: more questions than answers.

    abstract::Beneficial effects on health of limiting food intake for certain periods of time have been recognized for a long time. While many diets can produce short-term weight loss, most fail to result in a long-lasting impact. Current data suggest that intermittent fasting may be beneficial for overall health and wellbeing. Ho...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.08.007

    authors: Skaznik-Wikiel ME,Polotsky AJ

    更新日期:2014-11-01 00:00:00

  • In utero exposure to carcinogens: Epigenetics, developmental disruption and consequences in later life.

    abstract::The uterine environment is often viewed as a relatively safe haven, being guarded by the placenta which acts as a filter, permitting required materials to enter and unwanted products to be removed. However, this defensive barrier is sometimes breached by potential chemical hazards to which the mother may be subjected....

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2016.01.008

    authors: Waring RH,Harris RM,Mitchell SC

    更新日期:2016-04-01 00:00:00

  • Motives for initiation, temporary discontinuation, and permanent discontinuation of hormone replacement therapy use among Norwegian women.

    abstract:OBJECTIVE:The use of hormone replacement therapy (HRT) declined strongly in many countries after publication of the WHI-study. The purpose of the present study was to investigate HRT usage patterns and motives for initiation, temporary discontinuation, and permanent discontinuation of HRT use among Norwegian women. ME...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2009.07.010

    authors: Øren A

    更新日期:2009-09-20 00:00:00

  • Expression of estrogen receptor (ER) in oral mucosa and salivary glands.

    abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(00)00138-9

    authors: Leimola-Virtanen R,Salo T,Toikkanen S,Pulkkinen J,Syrjänen S

    更新日期:2000-08-31 00:00:00

  • Comparison of a transdermal continuous combined and an interrupted progestogen HRT.

    abstract:OBJECTIVES:Pilot study to compare the effects of a continuous combined hormone replacement therapy (HRT) regimen with an interrupted progestogen regimen administered transdermally, upon the endometrium of postmenopausal women, the incidence of amenorrhoea and relief of menopausal symptoms. METHODS:Fifty-nine postmenop...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2005.01.013

    authors: Cameron ST,Glasier AF,Gebbie A,Dewart H,Baird DT

    更新日期:2006-01-10 00:00:00

  • Stopping ovarian cancer screening in BRCA1/2 mutation carriers: effects on risk management decisions & outcome of risk-reducing salpingo-oophorectomy specimens.

    abstract:OBJECTIVE:Ovarian cancer screening (OCS) for BRCA1/2 mutation carriers was stopped in our family cancer clinic in 2009 because of its ineffectiveness. The study objective was to investigate the effect of stopping OCS on the timing and uptake of risk-reducing salpingo-oophorectomy (RRSO) and on the percentage of occult ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.12.009

    authors: van Driel CM,de Bock GH,Arts HJ,Sie AS,Hollema H,Oosterwijk JC,Mourits MJ

    更新日期:2015-03-01 00:00:00

  • Alternative scoring for Physical Activity Scale for the Elderly (PASE).

    abstract:BACKGROUND:Studies assessing physical functioning with the Physical Activity Scale for the Elderly (PASE) should be aware that the instrument may be age and culture insensitive. OBJECTIVES:To asses "classical" PASE scoring in a sample of aged (mean age 74) Mexican origin Latinos in the Southwestern United States and p...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2012.05.009

    authors: Siordia C

    更新日期:2012-08-01 00:00:00

  • Menstrual cycle length preceding menopause in relation to age at menopause.

    abstract:OBJECTIVES:In one of the earlier hypotheses of the etiology of breast cancer (Korenman's 'oestrogen window' hypothesis (1981)), it was assumed that women with a later age at menopause have a longer period with irregular cycles preceding menopause than women with an early menopause. This assumption was tested in a prosp...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(98)00013-9

    authors: den Tonkelaar I,te Velde ER,Looman CW

    更新日期:1998-06-03 00:00:00

  • Estrogens, progestins and lipid metabolism.

    abstract:OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(96)01012-2

    authors: Tikkanen MJ

    更新日期:1996-05-01 00:00:00

  • The mechanisms tumor cells utilize to evade the host's immune system.

    abstract::The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2017.04.014

    authors: Kuol N,Stojanovska L,Nurgali K,Apostolopoulos V

    更新日期:2017-11-01 00:00:00

  • Breast cancer molecular subtypes--modern therapeutic concepts for targeted therapy of a heterogeneous entity.

    abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2012.08.006

    authors: Liedtke C,Kiesel L

    更新日期:2012-12-01 00:00:00