Abstract：
:To prevent hyperplasia and carcinoma of the endometrium during oestrogen replacement therapy (ORT), the addition of progestogens once a month is considered mandatory. However, there is no sound scientific basis for this assumption. As the addition of progestogens has several disadvantages, it is important to minimize the frequency of progestogen addition. Vaginosonography is a rather new technique which has not yet been used for monitoring ORT. In this study the increase in endometrial thickness, as measured by vaginosonography, was taken as an indicator of stimulation of the endometrium by oestrogens. Oestrogen treatment was started in post-menopausal women with little endometrium (thickness less than 3 mm). As long as there was virtually no increase during oestrogen treatment, no progestogen was added, but where considerable growth occurred (greater than 3 mm) progestogen was administered. By means of vaginosonography the growth of the endometrium can be monitored precisely on an individual basis. It is thus possible to distinguish women with a slow growing endometrium from those with an endometrium that grows fast. In this way it will perhaps become possible to minimize progestogen addition during ERT by tailoring dosage to individual requirements.
journal_name
Maturitasjournal_title
Maturitasauthors
Meuwissen JH,van Langen H,Moret E,Navarro-Morquecho Idoi
10.1016/0378-5122(92)90059-dkeywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
33-7issue
1eissn
0378-5122issn
1873-4111pii
0378-5122(92)90059-Djournal_volume
15pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/0378-5122(93)90055-m
更新日期：1993-03-01 00:00:00
abstract：:The objective of this systematic review and meta-analysis was to evaluate the efficacy and the effectiveness, as well as the safety and tolerability, of urethral bulking agents (UBAs) in women with mixed or stress urinary incontinence. PubMed, Scopus, and the Cochrane Central Register of Controlled Trials were used to...
journal_title：Maturitas
pub_type： 杂志文章,meta分析
doi：10.1016/j.maturitas.2019.12.007
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, trans...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(00)00225-5
更新日期：2001-07-25 00:00:00
abstract：AIMS:Women in the West can now expect to live one third of their life in a postmenopausal state, and consequently in a state of estrogen deficiency. This can have a number of consequences, and many women suffer vasomotor symptoms during the climacteric. Estrogen deficiency can also result in changes to the skin, hair, ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. DESIGN:Open-label randomized prospective comparative study. SETTING:Gynecological outpatient department of an university hospital....
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(94)90039-6
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.10.016
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:The use of hormone replacement therapy (HRT) declined strongly in many countries after publication of the WHI-study. The purpose of the present study was to investigate HRT usage patterns and motives for initiation, temporary discontinuation, and permanent discontinuation of HRT use among Norwegian women. ME...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.07.010
更新日期：2009-09-20 00:00:00
abstract：:Serum concentrations of 17 beta-oestradiol (E2), unconjugated oestrone (E1), total oestrone (tE1), progesterone (P), follicle-stimulating hormone (FSH) and sex-hormone-binding globulin (SHBG) were measured before and after daily intravaginal administration of 250 micrograms micronized E2 and 10 mg micronized P for 14 ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90066-7
更新日期：1988-12-01 00:00:00
abstract：OBJECTIVE:To describe the characteristics of women seeking treatment for symptoms of urinary incontinence (UI) in European countries. DESIGN:Prospective urinary incontinence research (PURE) was a 6-month, observational, pan-European study, primarily aimed at determining the direct costs of urinary incontinence treatme...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.maturitas.2005.09.003
更新日期：2005-11-30 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate bone protective effects of risedronate, atorvastatin, raloxifene and clomiphene citrate in ovariectomized rats. METHODS:Our study was conducted on 63 rats at Experimental Research Center of Celal Bayar University. Six-month-old rats were divided into seven groups. The...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.03.018
更新日期：2009-07-20 00:00:00
abstract：:Ageing populations represent a challenge to the sustainability of current healthcare systems. The need to balance these demographic changes with gains in healthy life years and quality of life (QoL) constitutes an additional challenge. Aware of this, the European Commission (EC) launched the European Innovation Partne...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2018.06.009
更新日期：2018-09-01 00:00:00
abstract：:The endometrial effect of long-term vaginal oestriol (E3) therapy for urogenital atrophy was assessed in 23 post-menopausal women. Hysteroscopic and histological examinations were performed in each patient to assess endometrial atrophy before treatment and after 6 and 12 months of therapy (0.5 mg vaginal E3 for 21 day...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(91)90235-i
更新日期：1991-10-01 00:00:00
abstract：:Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.12.006
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:Despite their public health importance, little is known about associations between modifiable lifestyles, quality of life (QOL), and psychiatric symptoms in men. We investigated relationships between QOL, obesity, mobility and lifestyle in Australian men, including whether associations were mediated by anxie...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.06.024
更新日期：2017-09-01 00:00:00
abstract：:Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90100-4
更新日期：1988-03-01 00:00:00
abstract：:Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossibl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(99)00069-9
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:In obese postmenopausal women with normal glucose metabolism (NGT) and impaired glucose tolerance (IGT) we assessed serum leptin, adiponectin, resistin, soluble leptin receptor (sOB-R) during oral glucose tolerance test (OGTT) in order to investigate their response to acute changes in glucose and insulin in t...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2008.03.012
更新日期：2008-04-20 00:00:00
abstract：OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00921-7
更新日期：1995-09-01 00:00:00
abstract：:The clinical profile of Org OD 14 ((7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5 (10)-en-20-yn-3-one) is remarkable in that the compound demonstrates simultaneous weak oestrogenic, androgenic and progestational activity after oral administration to animals. It was therefore studied to evaluate its efficacy in t...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(87)90038-7
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.01.013
更新日期：2006-09-20 00:00:00
abstract：:It is important for our aging population to remain active, particularly those with chronic diseases, like Parkinson disease (PD), which limit mobility. Recent studies in older adults and people with PD suggest dance interventions provide various motor benefits. The literature for dance in PD is growing, but many knowl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2015.02.007
更新日期：2015-05-01 00:00:00
abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(94)00855-2
更新日期：1995-01-01 00:00:00
abstract：:Sera were sampled from 83 people (pre- and post-menopausal women and men). Climacteric symptoms of 23 women were treated with conjugated estrogen. Sera were sampled serially until the 21st day of estrogen administration. Serum concentrations of 40 protein components were measured by micro single radial immunodiffusion...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(91)90282-u
更新日期：1991-03-01 00:00:00
abstract：:Since the launch in 2008 by the National Osteoporosis Guideline Group (NOGG), of guidance for the diagnosis and management of osteoporosis in postmenopausal women and older men in the UK there have been significant advances in risk assessment and treatment. These have been incorporated into an updated version of the g...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2013.05.013
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the putative changes in serum angiotensinase activities (aminopeptidase N, APN; aminopeptidase B, APB; aminopeptidase A, APA; aspartyl aminopeptidase, ASAP) involved in the renin-angiotensin system (RAS) in women with breast cancer treated or not with a neoadjuvant thera...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.02.007
更新日期：2012-05-01 00:00:00
abstract：:Most health decisions occur in contexts of scientific uncertainty, the "grey zone" of decision-making and many decisions faced by menopausal women are no exception. These contexts are characterized either by scientific evidence that points to a balance between harms and benefits within or between options, or by the ab...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.01.013
更新日期：2009-07-20 00:00:00
abstract：:The uterine environment is often viewed as a relatively safe haven, being guarded by the placenta which acts as a filter, permitting required materials to enter and unwanted products to be removed. However, this defensive barrier is sometimes breached by potential chemical hazards to which the mother may be subjected....
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.01.008
更新日期：2016-04-01 00:00:00
abstract：UNLABELLED:Social engagement provides dynamic stimulation for older individuals that influences cognition. Grandparenting is an increasingly popular form of childcare that provides social activity for older adults. OBJECTIVE:To investigate the relationship between grandparenting, as a form of social engagement, and co...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.03.013
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:C-telopeptide crosslaps (CTX) and bone-specific alkaline phosphatase (BAP) do not provide sufficient sensitivity and specificity for diagnosis of osteoporosis. Cathepsin K (CatK), osteoprotegerin (OPG), and receptor activator of nuclear factor κB ligand (total (t) and soluble (s) RANKL) play an important rol...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.01.005
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:To examine whether physical activity during the last five years is related to later breast mammographic density in postmenopausal Greek women. METHODS:We designed a cross-sectional study in 724 women, of ages 45-67 years. An interview-administered questionnaire was used to obtain information on duration and ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2011.02.003
更新日期：2011-05-01 00:00:00
