Abstract：
CONTEXT AND OBJECTIVE:The aim of this study was to describe hot flushes in men with prostate cancer, and their treatment methods. METHOD:A systematic review was conducted of the literature indexed between 1966 and 2009 on the MEDLINE, the ISI Web of Knowledge, Cinahl and PsycINFO. Of 252 articles identified, 32 were selected for consideration of their complete texts, of which five were subject to detailed analysis. RESULTS:Diethylstilbestrol, megestrol acetate and cyproterone acetate have the strongest effect, giving a 75% or larger decrease of the number of hot flushes, but they may have severe or bothersome side-effects. Gabapentin has an uncertain effect. Clonidine is not proven effective for hot flushes. Long-term effects were not evaluated in any of the studies. SSRI/SNRI and acupuncture may have a moderate effect on hot flushes but are not proven in any RCTs. CONCLUSION:Hot flushes are common and bothersome symptoms in men with prostate cancer and those taking anti-androgen treatment, and reduce quality of life. Few treatments are available and some are avoided for these patients. Additional prospective treatment studies are needed, with long-term follow-up, in order to evaluate the effects and risks of treatments. Treatments with few or no severe side-effects should be prioritised in future investigations. Experimental studies are also needed to elucidate the mechanism behind hot flushes in men and to suggest routes for the development of new treatments.
journal_name
Maturitasjournal_title
Maturitasauthors
Frisk Jdoi
10.1016/j.maturitas.2009.10.017subject
Has Abstractpub_date
2010-01-01 00:00:00pages
15-22issue
1eissn
0378-5122issn
1873-4111pii
S0378-5122(09)00398-3journal_volume
65pub_type
杂志文章,评审相关文献
MATURITAS文献大全abstract：:We investigated the long-term effects of oral estriol (E3) on bone mineral density (BMD) at the lumbar spine and biochemical indices of bone turnover in early menopausal women. We studied 64 healthy early menopausal women who were treated for 24 months with 2.0 mg E3 plus 2.5 mg medroxyprogesterone acetate daily (E3 g...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(97)00061-3
更新日期：1997-09-01 00:00:00
abstract：:Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(98)00056-5
更新日期：1998-09-20 00:00:00
abstract：OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.02.261
更新日期：2015-05-01 00:00:00
abstract：:In direct contrast to the observational studies, both primary and secondary prevention trials of female reproductive hormones have found no benefit for coronary heart disease (CHD). Basic science studies have elucidated several mechanisms by which estrogen may improve coronary arterial physiology and prevent pathology...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2005.02.015
更新日期：2005-05-16 00:00:00
abstract：:Ageing is accompanied with a progressive loss of muscle mass and force generating capacity. Ultimately, the muscle wasting and weakness may dramatically impact on mobility and the quality of life, where the elderly has increasing problems with performing activities of daily life, such as rising from a chair or climbin...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2012.07.015
更新日期：2012-11-01 00:00:00
abstract：:Fifty-six premenopausal women were drawn from a cross-sectional survey of 850 women living in South-East England. They were recontacted 3 years later when 36 met the criterion of being naturally peri- or postmenopausal. Somatic, vasomotor and emotional symptoms, as well as general health, use of medical services and b...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(92)90004-n
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To analyze the effects of statin use on bone turnover markers (BTM), in participants from a large population-based cohort. SUBJECTS AND METHODS:Cross-sectional study that included 2431 subjects (1401 women and 930 men) from the Camargo Cohort. We analyzed the differences in serum BTM between statin or non-st...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.02.003
更新日期：2013-05-01 00:00:00
abstract：:Two case reports of women treated with an individual cognitive behavioral treatment (CBT) for menopausal hot flashes are presented. Both women reported substantial improvements in the number of hot flashes experienced as well as in their quality of life as measured by the Menopause Quality of Life Scale (MENQOL), the ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.12.006
更新日期：2006-04-20 00:00:00
abstract：OBJECTIVES:The objectives of the study were to find the prevalence of major depressive disorder (MDD) in male climacteric outpatients in Japan, and to determine whether symptoms on the Aging Males' Symptoms (AMS) scale scores differed between patients with and without MDD, with the aim of increasing the specificity of ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.04.001
更新日期：2006-01-20 00:00:00
abstract：:The uterine environment is often viewed as a relatively safe haven, being guarded by the placenta which acts as a filter, permitting required materials to enter and unwanted products to be removed. However, this defensive barrier is sometimes breached by potential chemical hazards to which the mother may be subjected....
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.01.008
更新日期：2016-04-01 00:00:00
abstract：:To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00111-0
更新日期：2000-05-29 00:00:00
abstract：OBJECTIVES:It has become popular to assert that Asian women in general have low midlife rates of reporting a wide variety of symptoms and that these rates are much lower than those found among women in western countries. Comparable data from mainland China remains sparse, however. This study aimed to uncover the sympto...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.12.010
更新日期：2006-08-20 00:00:00
abstract：OBJECTIVES:The aim of this study was to observe hysterectomized postmenopausal women (without progestogen, which could interfere in the results), using oral-conjugated oestrogen 0.625 mg daily (n=13) or 17beta-estradiol transdermal patches delivering 50 microg daily (n=10) during 12 months, and to evaluate the treatmen...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/s0378-5122(03)00159-2
更新日期：2003-09-25 00:00:00
abstract：OBJECTIVE:This study aimed to investigate how whole-body vibration (WBV) and exercise and their interactions influenced leg muscle activity in elderly adults. STUDY DESIGN:An experimental study with repeated measures design that involved a group of ambulatory, community-dwelling elderly adults (n=30; 23 women; mean ag...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.03.011
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. DESIGN:A 3-year non-comparative prospective clinical trial. SUBJECT...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2003.07.002
更新日期：2004-05-28 00:00:00
abstract：OBJECTIVE:Deficiency of the gene encoding endothelial nitric oxide synthase, i.e. Nos3, has been reported to be associated with late menarche, reduced ovulation rates, fewer deliveries, and earlier onset of menopause in a mouse model. METHODS:We assessed the Glu298Asp and the T-786C polymorphisms of Nos3 in 87 consecu...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.01.004
更新日期：2004-10-15 00:00:00
abstract：OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(01)00224-9
更新日期：2001-09-28 00:00:00
abstract：:Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol,...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(86)90035-6
更新日期：1986-12-01 00:00:00
abstract：OBJECTIVE:The present study investigated bone turnover with exchange of hormone replacement therapy (HRT) by treatment with 1alpha-hydroxycholecalciferol in early postmenopausal women. METHODS:Subjects included a total of 75 postmenopausal women between 49 and 59 years of age who visited the Department of Obstetrics a...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(03)00130-0
更新日期：2003-06-30 00:00:00
abstract：:The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant los...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(96)01042-0
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.008
更新日期：2007-01-20 00:00:00
abstract：OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.01.013
更新日期：2006-09-20 00:00:00
abstract：:Health care focuses on controlling symptoms and managing risk factors to improve survival by avoiding future complications. Diagnoses describe a group of signs and symptoms, often implying specific aetiologies and underlying pathophysiological disease processes. The diagnosis provides a tool for the health professiona...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.02.010
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. METHODS:Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiti...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00068-3
更新日期：2002-07-25 00:00:00
abstract：OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(00)00159-6
更新日期：2000-11-30 00:00:00
abstract：BACKGROUND:Studies assessing physical functioning with the Physical Activity Scale for the Elderly (PASE) should be aware that the instrument may be age and culture insensitive. OBJECTIVES:To asses "classical" PASE scoring in a sample of aged (mean age 74) Mexican origin Latinos in the Southwestern United States and p...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.05.009
更新日期：2012-08-01 00:00:00
abstract：:Menopause is a time of anatomic, physiological and psychological changes that often influence in the sexuality of aging female. Being sexual functioning an important aspect of health and well-being, doctors should have an holistic approach reassuring about the possibility of treating the various symptoms. The central ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(02)00150-0
更新日期：2002-08-30 00:00:00
abstract：OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.10.016
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:Impaired vision and hearing are common among older adults and have been shown to reduce functional independence and to reduce quality of life. This cohort study investigated the cross-sectional and temporal associations between objectively measured dual sensory impairment (DSI) and retirement from employment....
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.03.318
更新日期：2017-06-01 00:00:00
abstract：:Epidemiological studies have shown that cigarette smoking is associated with an increased risk of midlife hot flashes; however, the effect of quitting smoking on this risk is unclear. The purpose of this study was to examine the effect of quitting smoking on hot flashes using data from 761 women aged 45 to 54 years of...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.06.029
更新日期：2015-09-01 00:00:00
