Abstract：
:The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant loss of BMD during the study period but the premenopausal women did not. The annual percent decrease of BMD (delta BMD) in the perimenopausal women (-2.40% in average) was significantly greater than that in either of the premenopausal (-0.01%) or over-all postmenopausal women (-0.85%). The subjects who had been postmenopausal for less than 10 years showed a significant bone loss. delta BMD in the postmenopausal women became less marked as the postmenopausal duration increased. The bone loss was accelerated for about 10 years after menopause. The pattern and magnitude of bone loss of Japanese women seemed to be similar to those of Caucasian women. The regression equation for delta BMD based on the bone turnover markers at baseline was shown to be significant in the postmenopausal women and the serum level of bone-specific alkaline phosphatase isoenzyme had a significant relation to delta BMD. However, this equation accounted for only 17.3% of the total variance of delta BMD and, hence, its validity was not sufficiently high for the prediction of bone loss in clinical settings.
journal_name
Maturitasjournal_title
Maturitasauthors
Iki M,Kajita E,Dohi Y,Nishino H,Kusaka Y,Tsuchida C,Yamamoto K,Ishii Ydoi
10.1016/0378-5122(96)01042-0subject
Has Abstractpub_date
1996-08-01 00:00:00pages
59-67issue
1eissn
0378-5122issn
1873-4111pii
0378512296010420journal_volume
25pub_type
杂志文章相关文献
MATURITAS文献大全abstract：OBJECTIVE:To evaluate the pharmacodynamic effects of a novel intrauterine drug delivery system, FibroPlant-levonorgestrel (LNG), on the endometrium in 24 postmenopausal women using estrogen substitution therapy (EST) to suppress climacteric symptoms. DESIGN:A 3-year non-comparative prospective clinical trial. SUBJECT...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2003.07.002
更新日期：2004-05-28 00:00:00
abstract：:Gynecological literature is replete with multiple papers on sexually transmitted infections (STIs) in young women. Although those past the reproductive prime may well be at lower risk for STIs than women in the peak reproductive years, STIs are regularly seen in the older cohort and are a cause for significant morbidi...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2010.05.003
更新日期：2010-10-01 00:00:00
abstract：:The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(81)90003-7
更新日期：1981-08-01 00:00:00
abstract：:Recent findings in stem cell biology have presented new perspectives and opportunities for the treatment of reproductive disease. In a departure from the long held dogma of embryologically fixed numbers of oocytes, current literature suggests that human ovaries contain stem cells which form new oocytes even in adultho...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2013.08.012
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2006.11.001
更新日期：2007-04-20 00:00:00
abstract：:Administration of calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) can cause facial flushing, suggesting that the peptides may be important in hot flushes experienced particularly by post-menopausal women. Five studies have measured plasma CGRP concentrations in post-menopausal women who suffer from flush...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.08.011
更新日期：2009-10-20 00:00:00
abstract：OBJECTIVES:To test the hypothesis that differences by gender will be observed in the association of hip fracture risk with stages of cognitive impairment; and to explore the association between Petersen's "mild cognitive impairment" (MCI) and DSM-5 "mild neurocognitive disorder" (MND). STUDY DESIGN:A community sample ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.12.007
更新日期：2018-03-01 00:00:00
abstract：:Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This occurs in both genders but compared with postmenopausal women, men a...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.01.006
更新日期：2019-04-01 00:00:00
abstract：:By establishing a statistical profile of the average sexual behaviour of women during the climacteric period, an attempt was made to determine what influence the climacteric had on female sexual activity. With the advancement of age, the sexual activity of women tends to decline. The menopause itself tends to further ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90016-0
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVE:To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. DESIGN:Open-label randomized prospective comparative study. SETTING:Gynecological outpatient department of an university hospital....
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(94)90039-6
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:To examine the prevalence and correlates of foot problems in older women over a 6-year period. STUDY DESIGN:Women aged 70-75 years who participated in the Australian Longitudinal Study on Women's Health completed a postal questionnaire incorporating questions relating to demographics, major medical condition...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2010.08.010
更新日期：2011-01-01 00:00:00
abstract：:Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2015.07.004
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlatio...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2014.12.011
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.10.016
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:To develop and evaluate a 30-min online training for managers, in order to improve menopause-related knowledge, attitudes and confidence in having supportive discussions with women experiencing menopausal symptoms at work. The study also explored intentions and behaviour in terms of having conversations. ST...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.12.001
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:The aim of this prospective 3-year clinical study was to examine the effect of hormone replacement therapy (HRT) on uterine fibroid growth among postmenopausal women. METHODS:Thirty-seven postmenopausal women with uterine solitary fibroids were recruited randomly for HRT in a 3-year program. All participants...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00159-7
更新日期：2002-09-30 00:00:00
abstract：:While the benefits of progestins in hormonal replacement therapy are well recognized as far as endometrial protection is concerned the data on breast tissue and the cardiovascular system are contentious. Following the Women's Health Initiative study, the Million Women Study and The Women's International Study of Long-...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2008.12.019
更新日期：2009-04-20 00:00:00
abstract：OBJECTIVE:To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS:This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.05.003
更新日期：2018-08-01 00:00:00
abstract：:Forty-five healthy postmenopausal women participated in a study designed to examine the effects on bone and mineral metabolism of SHD 386L, a new hormone replacement therapy (HRT) regime. This oral preparation delivers 2 mg estradiol valerate daily and 75 micrograms of levonorgestrel from days 17-28 inclusive of a 28-...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(92)90114-j
更新日期：1992-03-01 00:00:00
abstract：OBJECTIVE:To describe the characteristics of women seeking treatment for symptoms of urinary incontinence (UI) in European countries. DESIGN:Prospective urinary incontinence research (PURE) was a 6-month, observational, pan-European study, primarily aimed at determining the direct costs of urinary incontinence treatme...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.maturitas.2005.09.003
更新日期：2005-11-30 00:00:00
abstract：OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00138-9
更新日期：2000-08-31 00:00:00
abstract：:This study was a cross-sectional survey of mid-aged Thai women with the following aims: to describe their experience of symptoms and attitudes to menopause and to examine the relationships between symptoms, attitudes to menopause, sociodemographic variables and menopausal status. The sample was 268 women aged between ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(96)01058-4
更新日期：1997-01-01 00:00:00
abstract：:The reduction of gonadotrophin levels, urinary calcium and hot flushes in post-menopausal patients by ethinyl oestradiol is shown to be dose dependent, near maximum response being achieved by a dose of 15 micrograms daily. Equivalent ethinyl oestradiol doses to a number of other gonadal hormone preparations have been ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90060-3
更新日期：1982-12-01 00:00:00
abstract：:Since the launch in 2008 by the National Osteoporosis Guideline Group (NOGG), of guidance for the diagnosis and management of osteoporosis in postmenopausal women and older men in the UK there have been significant advances in risk assessment and treatment. These have been incorporated into an updated version of the g...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2013.05.013
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Studies assessing physical functionality with questions on ability to perform activities of daily living (ADLs) commonly make use of self- and informant-report measures. OBJECTIVES:Delineate the scenarios from which disagreement can arise and show evidence for the presence of disagreements when reporting on...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.06.012
更新日期：2012-10-01 00:00:00
abstract：:The aim of the study was to investigate the influence of long-term administration of oral contraceptives on bone density in climacteric women. The existence of a correlation between long-term use and bone density was confirmed. ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90103-x
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVES:To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055. METHODS:Between May 1999 and December 2001, we accrued 136 breast cancer survivors aged 35-5...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(02)00349-3
更新日期：2003-03-14 00:00:00
abstract：:For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2005.01.002
更新日期：2006-01-10 00:00:00
abstract：:Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(88)90100-4
更新日期：1988-03-01 00:00:00
