Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women.


:The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant loss of BMD during the study period but the premenopausal women did not. The annual percent decrease of BMD (delta BMD) in the perimenopausal women (-2.40% in average) was significantly greater than that in either of the premenopausal (-0.01%) or over-all postmenopausal women (-0.85%). The subjects who had been postmenopausal for less than 10 years showed a significant bone loss. delta BMD in the postmenopausal women became less marked as the postmenopausal duration increased. The bone loss was accelerated for about 10 years after menopause. The pattern and magnitude of bone loss of Japanese women seemed to be similar to those of Caucasian women. The regression equation for delta BMD based on the bone turnover markers at baseline was shown to be significant in the postmenopausal women and the serum level of bone-specific alkaline phosphatase isoenzyme had a significant relation to delta BMD. However, this equation accounted for only 17.3% of the total variance of delta BMD and, hence, its validity was not sufficiently high for the prediction of bone loss in clinical settings.






Iki M,Kajita E,Dohi Y,Nishino H,Kusaka Y,Tsuchida C,Yamamoto K,Ishii Y




Has Abstract


1996-08-01 00:00:00














  • Access to Learning Opportunities for Residents in Care Homes: Reviewing the challenges and possibilities.

    abstract::International, national and regional policy documents and key reports espouse the benefits of lifelong learning and people's rights to it, yet little attention has been given to the learning needs of frail older people in nursing (care) homes. People living in care have frequently been cited as a forgotten sector of t...


    pub_type: 杂志文章,评审


    authors: Kydd A,Fulford H

    更新日期:2020-10-01 00:00:00

  • Magnitude, symmetry and attenuation of upper body accelerations during walking in women: The role of age, fall history and walking surface.

    abstract:OBJECTIVES:The present experiment examined the role of age and fall history in upper body accelerations when walking on an even and on an uneven surface. STUDY DESIGN:An observational cross-sectional study. MAIN OUTCOME MEASURES:The magnitude (root mean square [RMS]), symmetry (harmonic ratio) and attenuation (attenu...


    pub_type: 杂志文章


    authors: Soleimanifar M,Mazaheri M,van Schooten KS,Asgari M,Mosallanezhad Z,Salavati M,Sedaghat-Nejad E,Parnianpour M

    更新日期:2020-09-01 00:00:00

  • EMAS position statement: Managing the menopause in women with a past history of endometriosis.

    abstract:INTRODUCTION:Endometriosis is a common disease in women of reproductive age. The symptoms usually disappear after a natural or a surgical menopause. Estrogen-based hormone therapy is required in women with premature or early menopause until the average age of the natural menopause and should be considered in older wome...


    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Moen MH,Rees M,Brincat M,Erel T,Gambacciani M,Lambrinoudaki I,Schenck-Gustafsson K,Tremollieres F,Vujovic S,Rozenberg S,European Menopause and Andropause Society.

    更新日期:2010-09-01 00:00:00

  • Comparison of calcium, calcitriol, ovarian hormones and nandrolone in the treatment of osteoporosis.

    abstract::Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol,...


    pub_type: 杂志文章


    authors: Need AG,Chatterton BE,Walker CJ,Steurer TA,Horowitz M,Nordin BE

    更新日期:1986-12-01 00:00:00

  • A longitudinal study of the effects of menopause on sexuality.

    abstract::From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...


    pub_type: 杂志文章


    authors: McCoy NL,Davidson JM

    更新日期:1985-09-01 00:00:00

  • Postmenopausal hormone therapy and mammographic breast density.

    abstract:OBJECTIVE:The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS:In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die ...


    pub_type: 杂志文章,随机对照试验


    authors: Marchesoni D,Driul L,Ianni A,Fabiani G,Della Martina M,Zuiani C,Bazzocchi M

    更新日期:2006-01-10 00:00:00

  • Quality of life among postmenopausal Ecuadorian women participating in a metabolic syndrome screening program.

    abstract:BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...


    pub_type: 杂志文章


    authors: Chedraui P,Hidalgo L,Chavez D,Morocho N,Alvarado M,Huc A

    更新日期:2007-01-20 00:00:00

  • The most bothersome symptom of vaginal atrophy: Evidence from the observational AGATA study.

    abstract:OBJECTIVES:Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN:Cross-secti...


    pub_type: 杂志文章,多中心研究


    authors: Palma F,Xholli A,Cagnacci A,as the writing group of the AGATA study.

    更新日期:2018-02-01 00:00:00

  • Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.

    abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant furth...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nerbrand C,Nyberg P,Nordström L,Samsioe G

    更新日期:2002-05-20 00:00:00

  • Oestrogen regulated gene expression in normal and malignant endometrial tissue.

    abstract:OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...


    pub_type: 杂志文章


    authors: O'Toole SA,Dunn E,Sheppard BL,Sheils O,O'Leary JJ,Wuttke W,Seidlova-Wuttke D

    更新日期:2005-06-16 00:00:00

  • The risk factors and symptomatology of perimenopausal depression.

    abstract:OBJECTIVES:The aim of this study is to determine if the depression in perimenopausal women is symptomatologically different than depression in premenopausal women, and if these depressive women are under more risk for depression when factors like premenstrual dysphoric syndrome, socio-economical status, vasomotor sympt...


    pub_type: 杂志文章


    authors: Oztürk O,Eraslan D,Mete HE,Ozşener S

    更新日期:2006-09-20 00:00:00

  • The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease.

    abstract:OBJECTIVES:The current study investigated the neurotrophic and neuroprotective action of the complex formulation of conjugated equine estrogens (CEEs), the most frequently prescribed estrogen replacement therapy in the United States and the estrogen replacement therapy of the Women's Health Initiative. METHODS:Videomi...


    pub_type: 杂志文章


    authors: Brinton RD,Chen S,Montoya M,Hsieh D,Minaya J

    更新日期:2000-04-01 00:00:00

  • Low androstenedione/sex hormone binding globulin ratio increases fracture risk in postmenopausal women. The Women's Health in the Lund Area study.

    abstract::The Women's Health in the Lund Area (WHILA) project (n=6917) is a cohort study that started in 1995 and includes a postal questionnaire, physical examination, bone density measurement and blood laboratory analyses. Fracture data have been added, and in this report fracture risk and its association with sex hormones wa...


    pub_type: 杂志文章


    authors: Moberg L,Nilsson PM,Samsioe G,Borgfeldt C

    更新日期:2013-07-01 00:00:00

  • Predictive ability and reliability of the STOP-BANG questionnaire in screening for obstructive sleep apnea in midlife women.

    abstract:OBJECTIVES:The STOP-BANG questionnaire (snoring, tiredness, observed apneas, high blood pressure, body mass index, age, neck size, gender) was originally validated to screen for obstructive sleep apnea (OSA) in the surgical population. It has been validated in mixed populations of men and women. We aimed to evaluate it...


    pub_type: 杂志文章


    authors: Orbea CAP,Lloyd RM,Faubion SS,Miller VM,Mara KC,Kapoor E

    更新日期:2020-05-01 00:00:00

  • Self-reported menopausal symptoms in a racially diverse population and soy food consumption.

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    pub_type: 杂志文章


    authors: Reed SD,Lampe JW,Qu C,Gundersen G,Fuller S,Copeland WK,Newton KM

    更新日期:2013-06-01 00:00:00

  • Management of patients with non-atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: long-term follow-up.

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    pub_type: 临床试验,杂志文章


    authors: Wildemeersch D,Janssens D,Pylyser K,De Wever N,Verbeeck G,Dhont M,Tjalma W

    更新日期:2007-06-20 00:00:00

  • Gender paradox in cardiac calcium deposits in middle-aged and elderly patients: mitral annular and coronary calcifications interrelationship.

    abstract:OBJECTIVES:mitral annular calcification (MAC) occurs mainly in middle-aged and elderly patients and can lead to serious clinical consequences. Male predominance in the prevalence of coronary disease is well-established. Paradoxically, the prevalence of MAC, which is theoretically based on the same etiological mechanism...


    pub_type: 杂志文章


    authors: Tenenbaum A,Fisman EZ,Pines A,Shemesh J,Shapira I,Adler Y,Frenkel Y,Boyko V,Motro M

    更新日期:2000-07-31 00:00:00

  • A case-control study of endometrial cancer within a cohort.

    abstract::In a population-based prospective study it was shown that weight, height, overweight, total body size, age at first birth, parity and age at menopause are risk factors for the development of endometrial cancer. The finding that the patients had had a higher oestrogen excretion level than the controls some time before ...


    pub_type: 杂志文章


    authors: Baanders-van Halewijn EA,Poortman J

    更新日期:1985-05-01 00:00:00

  • Comparing TCM textbook descriptions of menopausal syndrome with the lived experience of London women at midlife and the implications for Chinese medicine research.

    abstract::Almost without exception clinical research seeking to evaluate the effectiveness of Chinese medicine relies on TCM textbook knowledge - accessed directly or via practitioners' clinical usage - in order to frame its hypotheses. Recent historical research shows that these textbooks, products of a politically directed pr...


    pub_type: 历史文章,杂志文章


    authors: Scheid V,Ward T,Tuffrey V

    更新日期:2010-08-01 00:00:00

  • Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review.

    abstract::The identification of early biochemical predictors of osteoarthritis (OA) has been the focus of much research over the past few years. However, it still is unclear whether current biochemical markers can be used in prognostic risk assessment of OA. The aim of this systematic review is to evaluate the possible prognost...


    pub_type: 杂志文章,评审


    authors: Hosnijeh FS,Runhaar J,van Meurs JB,Bierma-Zeinstra SM

    更新日期:2015-09-01 00:00:00

  • Therapeutic targets for premature ejaculation.

    abstract::Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all pati...


    pub_type: 杂志文章,评审


    authors: Andersson KE,Abdel-Hamid IA

    更新日期:2011-09-01 00:00:00

  • Bilateral Leydig cell tumour of the ovary: a rare cause of virilization in postmenopausal patient.

    abstract:BACKGROUND:Leydig cell tumours of the ovary are very rare benign neoplasms, frequently associated with symptoms of virilisation, in postmenopausal patients. Only four cases of bilateral Leydig tumours have been reported in the literature. CASE REPORT:We report an additional case of bilateral presentation. A 77-year-ol...


    pub_type: 杂志文章


    authors: Sanz OA,Martinez PR,Guarch RT,Goñi MJ,Alcazar JL

    更新日期:2007-06-20 00:00:00

  • Reducing inappropriate prescribing for older adults with advanced frailty: A review based on a survey of practice in four countries.

    abstract::The management of medications in persons with frailty presents challenges. There is evidence of inappropriate prescribing and a lack of consensus among healthcare professionals on the judicious use of medications, particularly for patients with more severe frailty. This study reviews the evidence on the use of commonl...


    pub_type: 杂志文章,评审


    authors: O'Caoimh R,Cornally N,McGlade C,Gao Y,O'Herlihy E,Svendrovski A,Clarnette R,Lavan AH,Gallagher P,William Molloy D

    更新日期:2019-08-01 00:00:00

  • The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis.

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    pub_type: 杂志文章


    authors: Schnatz PF,Nudy M,O'Sullivan DM,Jiang X,Cline JM,Kaplan JR,Clarkson TB,Appt SE

    更新日期:2012-10-01 00:00:00

  • Latin American position on the current status of hormone therapy during the menopausal transition and thereafter.

    abstract:OBJECTIVE:Data from placebo-controlled, randomized clinical trials conducted during the past few years resulted in critical re-evaluation of the overall health benefits of hormone therapy (HT) in women during the menopausal transition and thereafter. These data stimulated vigorous debate among experts and produced seve...


    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Maia H Jr,Albernaz MA,Baracat EC,Barbosa IC,Bossemeyer R,Bueno AH,Campos OG,Carranza-Lira S,Casas PF,Castro AM,de Lima GR,de Melo NR,Fernandes CE,González JS,Larrañaga FE,Siseles N,Uribe AM,Vilchez RM,Latin American E

    更新日期:2006-08-20 00:00:00

  • The effect of occupation type on risk of Alzheimer's disease in men and women.

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    pub_type: 杂志文章


    authors: Santabárbara J,Gracía-Rebled AC,López-Antón R,Tomás C,Lobo E,Marcos G,Lobo A

    更新日期:2019-08-01 00:00:00

  • The role of clinical breast examination in cancer screening for women at average risk: A mini review.

    abstract::As the debate about the potential benefits and harms of screening mammography continues, it is timely to consider the role of clinical breast examination in screening for women at average risk of breast cancer. This article reviews the results from clinical trials and discusses the varied recommendations around the wo...


    pub_type: 杂志文章,评审


    authors: Brennan ME

    更新日期:2016-10-01 00:00:00

  • Bone turnover markers in statin users: a population-based analysis from the Camargo Cohort Study.

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    pub_type: 杂志文章


    authors: Hernández JL,Olmos JM,Romaña G,Martinez J,Castillo J,Yezerska I,Ramos C,González-Macías J

    更新日期:2013-05-01 00:00:00

  • Effects of tibolone and raloxifene on health-related quality of life and sexual function.

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Nijland EA,Weijmar Schultz WC,Davis SR

    更新日期:2007-10-20 00:00:00

  • Increased menopausal symptoms among Afro-Colombian women as assessed with the Menopause Rating Scale.

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    pub_type: 杂志文章


    authors: Monterrosa A,Blumel JE,Chedraui P

    更新日期:2008-02-20 00:00:00