Effect of conjugated estrogens with and without medrogestone: a prospective study.

Abstract:

OBJECTIVE:To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. DESIGN:Open-label randomized prospective comparative study. SETTING:Gynecological outpatient department of an university hospital. PATIENTS:Thirty-three healthy hysterectomized postmenopausal women. INTERVENTIONS:Continuous oral supplementation with conjugated estrogens, 0.625 mg daily, was administered either alone (group I; N = 18) or in combination with cyclic medrogestone, 5 mg daily during the last 12 days of each 28 days treatment cycle (group II; N = 15). MAIN OUTCOME MEASURE:Changes in serum lipids, lipoproteins and apolipoproteins after three, six and 13 treatment cycles. RESULTS:After 1 year of treatment significant increases were observed in mean high-density lipoprotein (HDL) cholesterol, its subfractions, and apolipoprotein A-I in group I and II: HDL cholesterol: +25.2% and +12.1%, respectively; HDL2 cholesterol: +47.4% and +23.5%, respectively; HDL3 cholesterol: +18.1% and +11.2%, respectively; apolipoprotein A-I: +23.0 and +14.8%, respectively. Comparing the two study groups no significant differences were found in lipid changes during the study period, except for HDL2 cholesterol. CONCLUSION:Supplementation with conjugated estrogens, with and without medrogestone, and given for a longer period, demonstrated a beneficial influence on serum lipoproteins with almost no differences between the two treatment regimens.

journal_name

Maturitas

journal_title

Maturitas

authors

van der Mooren MJ,Leuven JA,Rolland R

doi

10.1016/0378-5122(94)90039-6

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

33-42

issue

1

eissn

0378-5122

issn

1873-4111

pii

0378-5122(94)90039-6

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(95)00968-x

    authors: Hill K

    更新日期:1996-03-01 00:00:00

  • Menopause in Latin America: Symptoms, attitudes, treatments and future directions in Costa Rica.

    abstract::Similar to their US counterparts, Costa Rican women enter menopause at ∼50 years of age, have similar symptoms, including hot flashes and night sweats, as well as an overall negative attitude toward the menopausal transition. One study of rural women in Monteverde reported that women knew little about the menopausal t...

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    doi:10.1016/j.maturitas.2017.07.008

    authors: Locklear TD,Doyle BJ,Perez AL,Wicks SM,Mahady GB

    更新日期:2017-10-01 00:00:00

  • Poor general health and lower levels of vitality are associated with persistent, high-intensity low back pain and disability in community-based women: A prospective cohort study.

    abstract::While low back pain significantly impacts on an individual's well-being, our understanding of the role of well-being in the natural history of low back pain is limited. This cohort study aimed to investigate the association between psychological and general well-being and the development and progression of low back pa...

    journal_title:Maturitas

    pub_type: 杂志文章

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    authors: Ng SK,Cicuttini FM,Davis SR,Bell R,Botlero R,Fitzgibbon BM,Urquhart DM

    更新日期:2018-07-01 00:00:00

  • Hypertension in patients with type 2 diabetes mellitus: Targets and management.

    abstract::Two-thirds of patients with type 2 diabetes mellitus (T2DM) have arterial hypertension. Hypertension increases the incidence of both micro- and macrovascular complications in these patients, while the co-existence of these two major risk factors leads to a four-fold increased risk for cardiovascular disease (CVD) comp...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2018.03.013

    authors: Pavlou DI,Paschou SA,Anagnostis P,Spartalis M,Spartalis E,Vryonidou A,Tentolouris N,Siasos G

    更新日期:2018-06-01 00:00:00

  • Bone metabolism regulators and arterial stiffness in postmenopausal women.

    abstract:BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.07.001

    authors: Albu A,Fodor D,Bondor C,Crăciun AM

    更新日期:2013-10-01 00:00:00

  • Neuropsychiatric aspects of dementia.

    abstract::Dementia affects approximately 6.5% of people over the age of 65. Whilst cognitive impairment is central to the dementia concept, neuropsychiatric symptoms are invariably present at some stage of the illness. Neuropsychiatric symptoms result in a number of negative outcomes for the individual and their caregivers and ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.04.005

    authors: Ford AH

    更新日期:2014-10-01 00:00:00

  • Effect of programmed exercise on perceived stress in middle-aged and old women: A meta-analysis of randomized trials.

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    journal_title:Maturitas

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.maturitas.2018.05.004

    authors: Nigdelis MP,Martínez-Domínguez SJ,Goulis DG,Pérez-López FR

    更新日期:2018-08-01 00:00:00

  • A longitudinal study of the effects of menopause on sexuality.

    abstract::From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(85)90041-6

    authors: McCoy NL,Davidson JM

    更新日期:1985-09-01 00:00:00

  • Estrogens, progestins and lipid metabolism.

    abstract:OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(96)01012-2

    authors: Tikkanen MJ

    更新日期:1996-05-01 00:00:00

  • Premenopausal factors influencing premature ovarian failure and early menopause.

    abstract:OBJECTIVES:We conducted this study to examine premenopausal risk factors associated with premature ovarian failure (POF) and early menopause (EM) among Korean women. METHODS:A 73% of total women aged 30-69 at four districts in the KMCC (Korean Multi-center Cancer Cohort) was participated in this study during 2002-2003...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.04.001

    authors: Chang SH,Kim CS,Lee KS,Kim H,Yim SV,Lim YJ,Park SK

    更新日期:2007-09-20 00:00:00

  • Metabolic clearance rates of androgens and oestrogens in ageing women.

    abstract::Using the constant infusion technique we have measured the metabolic clearance rates (MCR) for delta 4-androstenedione (A), testosterone (T), oestrone (E1) and oestradiol (E2) in a large group of post-menopausal women. Their mean +/- SE age was 64.5 +/- 1.6 yr, their ages ranged from 46-90 yr. When the MCRs for each s...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(80)90030-4

    authors: Longcope C,Jaffee W,Griffing G

    更新日期:1980-12-01 00:00:00

  • Vitamin D and its implications for musculoskeletal health in women: an update.

    abstract::Vitamin D is a hormone that controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D synthesis is a process in which the skin, liver, and kidney are sequentially involved. The vitamin D pool is completed by the amount taken with food and supplements. Vitamin D deficiency causes osteopeni...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2007.05.002

    authors: Pérez-López FR

    更新日期:2007-10-20 00:00:00

  • Effects of mild and global cognitive impairment on the prevalence of fear of falling in community-dwelling older adults.

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    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.02.018

    authors: Uemura K,Shimada H,Makizako H,Doi T,Tsutsumimoto K,Yoshida D,Anan Y,Ito T,Lee S,Park H,Suzuki T

    更新日期:2014-05-01 00:00:00

  • Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels.

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    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(93)90120-7

    authors: Gonzales GF,Carrillo C

    更新日期:1993-07-01 00:00:00

  • A new peroral estrogen/progestin combination for postmenopausal hormonal substitution: an open multicentric field study.

    abstract::An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究

    doi:10.1016/0378-5122(93)90055-m

    authors: Haenggi W,Birkhaeuser MH

    更新日期:1993-03-01 00:00:00

  • Bone metabolism during the perimenopausal transition: a prospective study.

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    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(01)00248-1

    authors: Seifert-Klauss V,Mueller JE,Luppa P,Probst R,Wilker J,Höss C,Treumann T,Kastner C,Ulm K

    更新日期:2002-01-30 00:00:00

  • Hormonal replacement therapy and the skeletal system.

    abstract::The two most important risk factors for maintaining skeletal health are the bone mass obtained at skeletal maturity (peak bone mass) and the subsequent bone loss. Those women with a low peak bone mass and a rapid bone loss are thus at increased risk of developing osteoporosis in the future, and should be identified. T...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(90)90006-r

    authors: Christiansen C,Riis BJ

    更新日期:1990-09-01 00:00:00

  • Evaluating risk factors for differences in fibroid size and number using a large electronic health record population.

    abstract:OBJECTIVE:To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS:This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2018.05.003

    authors: Bray MJ,Torstenson ES,Jones SH,Edwards TL,Velez Edwards DR

    更新日期:2018-08-01 00:00:00

  • Diabetes and bone health.

    abstract::The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and s...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2013.04.004

    authors: Antonopoulou M,Bahtiyar G,Banerji MA,Sacerdote AS

    更新日期:2013-11-01 00:00:00

  • The impact of a monophasic continuous estro-progestogenic treatment on Latin American menopausal women.

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    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.maturitas.2004.05.014

    authors: Bassol S,Carranza-Lira S,Celis-Gonzalez C,Santoyo S,Murillo A,Martinez N,Santos J,Llaca V,de la Loza FR,Zarain J,da Fonseca AM,Camargos AF,Baracat EC,da Sá MF,Bayo J,Adaro L,Gurucharri C,Murga M,Siseles N,Sayegh F,

    更新日期:2005-03-14 00:00:00

  • Climacteric complaints and their relation to menopausal development--a retrospective analysis.

    abstract::The present study had two objectives: (1) to register the prevalence of a number of climacteric complaints in a Danish general population cohort and (2) retrospectively to test the validity of an association between climacteric complaints, menopausal development, occurrence of life events and social background. A post...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(93)90043-h

    authors: Køster A,Davidsen M

    更新日期:1993-11-01 00:00:00

  • Reprint of The Herbal Alternatives for Menopause (HALT) Study: background and study design.

    abstract::We designed a randomized double-blind randomized trial to examine the short and long-term effects of alternative approaches commonly used to manage menopause symptoms. Women were randomly assigned to: (1) black cohosh 160 mg daily; (2) multibotanical (50 mg black cohosh, alfalfa, chaste tree, dong quai, false unicorn,...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2008.11.014

    authors: Newton KM,Reed SD,Grothaus L,Ehrlich K,Guiltinan J,Ludman E,LaCroix AZ

    更新日期:2008-09-01 00:00:00

  • Pheochromocytoma: a review.

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    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2013.12.009

    authors: Tsirlin A,Oo Y,Sharma R,Kansara A,Gliwa A,Banerji MA

    更新日期:2014-03-01 00:00:00

  • Clinical profile of Org OD 14.

    abstract::The clinical profile of Org OD 14 ((7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5 (10)-en-20-yn-3-one) is remarkable in that the compound demonstrates simultaneous weak oestrogenic, androgenic and progestational activity after oral administration to animals. It was therefore studied to evaluate its efficacy in t...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/0378-5122(87)90038-7

    authors: Tax L,Goorissen EM,Kicovic PM

    更新日期:1987-01-01 00:00:00

  • Effect of hormone replacement therapy on uterine fibroids in postmenopausal women--a 3-year study.

    abstract:OBJECTIVE:The aim of this prospective 3-year clinical study was to examine the effect of hormone replacement therapy (HRT) on uterine fibroid growth among postmenopausal women. METHODS:Thirty-seven postmenopausal women with uterine solitary fibroids were recruited randomly for HRT in a 3-year program. All participants...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00159-7

    authors: Yang CH,Lee JN,Hsu SC,Kuo CH,Tsai EM

    更新日期:2002-09-30 00:00:00

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    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2017.10.006

    authors: Lee Y,Kim J,Chon D,Lee KE,Kim JH,Myeong S,Kim S

    更新日期:2018-01-01 00:00:00

  • Tibolone and climacteric symptoms.

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    pub_type: 杂志文章,评审

    doi:10.1016/0378-5122(94)00888-e

    authors: Ross LA,Alder EM

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  • The Kinmen women-health investigation (KIWI): a menopausal study of a population aged 40-54.

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    pub_type: 杂志文章

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    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(85)90024-6

    authors: Cugini P,Lucia P,Tomassini R,Letizia C,Murano G,Scavo D,Tamburrano G,Maldonato A,Halberg F,Schramm A

    更新日期:1985-07-01 00:00:00

  • Grand-parenting for healthy ageing in women: Fact or fiction?

    abstract::Globally our populations are ageing and with this trend, there is a rise in chronic disease. We know that lifestyle and environment are significant contributors to risk for disease, quality of life and function. Despite this representing an opportunity to improve health and quality of life in ageing, there is a paucit...

    journal_title:Maturitas

    pub_type: 社论

    doi:10.1016/j.maturitas.2016.07.004

    authors: Campbell S,Burn K,Szoeke C

    更新日期:2016-10-01 00:00:00