Abstract:
OBJECTIVE:To study the possible changes in serum lipids and lipoproteins during hormone replacement therapy with special emphasis on the possible effects brought about by the progestogen. DESIGN:Open-label randomized prospective comparative study. SETTING:Gynecological outpatient department of an university hospital. PATIENTS:Thirty-three healthy hysterectomized postmenopausal women. INTERVENTIONS:Continuous oral supplementation with conjugated estrogens, 0.625 mg daily, was administered either alone (group I; N = 18) or in combination with cyclic medrogestone, 5 mg daily during the last 12 days of each 28 days treatment cycle (group II; N = 15). MAIN OUTCOME MEASURE:Changes in serum lipids, lipoproteins and apolipoproteins after three, six and 13 treatment cycles. RESULTS:After 1 year of treatment significant increases were observed in mean high-density lipoprotein (HDL) cholesterol, its subfractions, and apolipoprotein A-I in group I and II: HDL cholesterol: +25.2% and +12.1%, respectively; HDL2 cholesterol: +47.4% and +23.5%, respectively; HDL3 cholesterol: +18.1% and +11.2%, respectively; apolipoprotein A-I: +23.0 and +14.8%, respectively. Comparing the two study groups no significant differences were found in lipid changes during the study period, except for HDL2 cholesterol. CONCLUSION:Supplementation with conjugated estrogens, with and without medrogestone, and given for a longer period, demonstrated a beneficial influence on serum lipoproteins with almost no differences between the two treatment regimens.
journal_name
Maturitasjournal_title
Maturitasauthors
van der Mooren MJ,Leuven JA,Rolland Rdoi
10.1016/0378-5122(94)90039-6subject
Has Abstractpub_date
1994-05-01 00:00:00pages
33-42issue
1eissn
0378-5122issn
1873-4111pii
0378-5122(94)90039-6journal_volume
19pub_type
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