Abstract:
OBJECTIVE:The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. METHODS:Eighty-six postmenopausal and 51 bilaterally ovariectomized women who had been suffering from vasomotor symptoms such as hot flush or atrophy of the vagina were randomly treated with HRT every other day or every day. Seventy-four patients received oral administration of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA) every other day, and 63 patients received oral administration of 0.625 mg CEE and 2.5 mg MPA every day as conventional HRT. RESULTS:Eighty-four postmenopausal and 50 bilaterally ovariectomized women completed this study. Serum estradiol levels after HRT every day in postmenopausal and bilaterally ovariectomized women were significantly (P <0.05 and <0.01, respectively) correlated with BMI, while those after HRT every other day were not correlated with BMI. The differences between estradiol levels after 12 months of treatment and initial estradiol levels were also significantly (P <0.01) correlated with BMI in both postmenopausal and bilaterally ovariectomized women who received HRT every day but not in women who received HRT every other day. Serum estrone level after HRT every day and the difference between estrone level after 12 months of treatment and initial estrone level were significantly (P <0.05 and <0.01, respectively) correlated with BMI only in bilaterally ovariectomized women. CONCLUSION:Serum estradiol levels after HRT every day increase more in overweight women than in non-overweight postmenopausal and bilaterally ovariectomized women. The results of the present study regarding the relationship between serum estradiol levels after HRT and BMI should be useful for selecting dosages of drugs to be used in HRT.
journal_name
Maturitasjournal_title
Maturitasauthors
Yasui T,Uemura H,Umino Y,Takikawa M,Saito S,Kuwahara A,Matsuzaki T,Maegawa M,Furumoto H,Miura M,Irahara Mdoi
10.1016/j.maturitas.2004.03.013keywords:
subject
Has Abstractpub_date
2005-01-10 00:00:00pages
19-29issue
1eissn
0378-5122issn
1873-4111pii
S0378512204001197journal_volume
50pub_type
临床试验,杂志文章,随机对照试验相关文献
MATURITAS文献大全abstract:OBJECTIVES:To develop a condition-specific quality of life (QoL) questionnaire to assess the symptoms of the decline in testosterone that occurs as men age, otherwise known as the andropause. METHODS:Two focus groups of patients with low testosterone levels and an expert panel of physicians in the treatment of male te...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00274-8
更新日期:2002-12-10 00:00:00
abstract:OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00224-9
更新日期:2001-09-28 00:00:00
abstract:OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(95)00921-7
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:In 1990 we initiated a 20 year, partly randomised study (Danish Osteoporosis Prevention Study, DOPS) in order to (a) evaluate clinical, biochemical and osteodensitometric variables as predictors of low bone mass and future osteoporotic fractures, and (b) test the hypothesis, that hormone replacement therapy (...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0378-5122(99)00006-7
更新日期:1999-03-15 00:00:00
abstract:OBJECTIVES:An internet survey was performed to obtain data on the current use in Belgium of hormone replacement therapy and alternative treatments for the alleviation of menopausal symptoms. A supplementary aim was to assess the use of opt-in internet opinion panels (TalkToChange, http://www.talktochange.com, and GMI, ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.04.018
更新日期:2016-08-01 00:00:00
abstract::The reduction of gonadotrophin levels, urinary calcium and hot flushes in post-menopausal patients by ethinyl oestradiol is shown to be dose dependent, near maximum response being achieved by a dose of 15 micrograms daily. Equivalent ethinyl oestradiol doses to a number of other gonadal hormone preparations have been ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(82)90060-3
更新日期:1982-12-01 00:00:00
abstract:OBJECTIVES:Many women have turned to complementary and alternative medicines for relief from their perimenopausal symptoms. The prevalence of plant-based medicine use among perimenopausal women highlights the need for investigation into these interventions. The aim of this study was to evaluate the benefit of soy prepa...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(03)00221-4
更新日期:2004-01-20 00:00:00
abstract::To analyse the relationship between nocturnal micturition and health in 40- to 64-year-old women. A questionnaire study was carried out in 3669 randomly selected women (out of 6000 invited) in the County of Jämtland, Sweden. Questions were asked about the general health status of health, health development during the ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00111-0
更新日期:2000-05-29 00:00:00
abstract:OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00138-9
更新日期:2000-08-31 00:00:00
abstract::The incidence of breast cancer has continued to decrease each year at Wilford Hall United States Air Force Medical Center with the ever-increasing use of combined progestogen-oestrogen replacement therapy over the past 12 yr. By 1983, the overall incidence of breast cancer had fallen to 53.9:100 000. The lowest rate f...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(86)90023-x
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed. METHODS:Review of the relevant literature and results from recent clinical trials. RESULT...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2008.02.008
更新日期:2008-05-20 00:00:00
abstract::Serum concentrations of 17 beta-oestradiol (E2), unconjugated oestrone (E1), total oestrone (tE1), progesterone (P), follicle-stimulating hormone (FSH) and sex-hormone-binding globulin (SHBG) were measured before and after daily intravaginal administration of 250 micrograms micronized E2 and 10 mg micronized P for 14 ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(88)90066-7
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:Elevation of blood pressure and heart rate increase the risk of cardiovascular disease. Administration of estrogens does not affect heart rate but may decrease 24 h blood pressure. In this study, we tested the effect of the estro-progestogenic compound tibolone. METHODS:Thirty healthy, post-menopausal women ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.maturitas.2003.08.011
更新日期:2004-06-15 00:00:00
abstract:OBJECTIVES:C-telopeptide crosslaps (CTX) and bone-specific alkaline phosphatase (BAP) do not provide sufficient sensitivity and specificity for diagnosis of osteoporosis. Cathepsin K (CatK), osteoprotegerin (OPG), and receptor activator of nuclear factor κB ligand (total (t) and soluble (s) RANKL) play an important rol...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.01.005
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVES:Qualitative studies show that women link menopause to the ageing process, and yet surprisingly little research has investigated how attitudes to ageing might shape women's experience of menopause, as well as their overall well-being at midlife. This study validated the Attitudes to Ageing Questionnaire (AAQ)...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.06.042
更新日期:2015-10-01 00:00:00
abstract::Gynaecologists have been criticized in recent years because of their attitude towards hysterectomy; it is often stated that they are too ready to consider hysterectomy to be indicated and that hysterectomies are carried out too frequently. In order to obtain insight into the incidence of hysterectomy, 2066 women betwe...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(83)90001-4
更新日期:1983-08-01 00:00:00
abstract::The aim of the research was to study the association between engagement in the recommended level of physical activity and quality of life (QoL) among middle-aged women. In total, 2606 Finnish women aged 49 years responded to a postal questionnaire on lifestyle, quality of life, and health, wherein QoL was assessed wit...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.09.009
更新日期:2015-01-01 00:00:00
abstract::The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.10.008
更新日期:2017-01-01 00:00:00
abstract::It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.03.027
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00247-0
更新日期:2004-02-20 00:00:00
abstract::Globally our populations are ageing and with this trend, there is a rise in chronic disease. We know that lifestyle and environment are significant contributors to risk for disease, quality of life and function. Despite this representing an opportunity to improve health and quality of life in ageing, there is a paucit...
journal_title:Maturitas
pub_type: 社论
doi:10.1016/j.maturitas.2016.07.004
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2005.01.002
更新日期:2006-01-10 00:00:00
abstract:OBJECTIVES:Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype's trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.03.002
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To examine the potential of a new matrix system developed for estradiol delivery to cause microbial proliferation under the occluded site or to cause acute phototoxicity reactions. METHODS:Twenty healthy post-menopausal women participated in a microbial proliferation study and 11 in a phototoxicity study. B...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(96)01062-6
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVE:To measure climacteric symptoms in a population-based survey as assessed by the Greene Climacteric Scale and to obtain normative data for the total score and subscales (psychological, somatic, vasomotor, and sexual) of the Greene Climacteric Scale. METHODS:A sample representative of the Dutch female populati...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00212-7
更新日期:2001-04-20 00:00:00
abstract::A prospective study was conducted amongst Hong Kong Chinese women to determine the incidence of acute menopausal symptoms following surgical menopause. Cases where a laparotomy was performed for other indications were used as controls. Hot flushes and sweating developed in 8/33 (24.2%) and 6/33 (18.2%), respectively, ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(94)90123-6
更新日期:1994-03-01 00:00:00
abstract::Pain has been associated with cognitive problems in pain patients. This study evaluated the extent to which experiences of pain are associated with cognitive performance in a community sample of mid-life women, and the contribution of depressive symptoms to this association. A cross-sectional analysis was used with da...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.10.013
更新日期:2015-01-01 00:00:00
abstract::The synthetic progestins used so far for contraception and menopausal hormone therapy are derived either from testosterone (19-nortestosterone derivatives) or from progesterone (17-OH progesterone derivatives and 19-norprogesterone derivatives). Among the 19-nortestosterone derivatives, the estrane group include noret...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2004.01.001
更新日期:2004-04-15 00:00:00
abstract::Serum cholesterol concentrations in lipoprotein fractions and subfractions were determined in 11 peri-menopausal women both before and after bilateral oophorectomy, as well as 60 days after commencement of oral oestradiol replacement therapy. Pre-operatively, all subjects were found to have normal lipid and lipoprotei...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(83)90002-6
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVES:This paper examines the evidence supporting testosterone replacement in aging males. Confounding factors contributing to low testosterone levels and challenges to diagnosis of the andropause will also be considered. METHODS:A thorough review using an integrative approach citing published literature and the ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(03)00083-5
更新日期:2003-05-30 00:00:00