Abstract:
OBJECTIVES:To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in estradiol bioavailability and concentrations. METHODS:In an open study, 23 healthy postmenopausal women were treated consecutively with 0.5, 1.0 and 1.5 mg estradiol daily as a transdermal gel. Each dose was given for 16 days. Venous blood samples for serum estradiol and estrone measurements with RIA were taken at steady state on the 16th study day. From these concentrations, pharmacokinetic parameters for estradiol were calculated and corrected to correspond to equal dose by dividing the values by the dose. RESULTS:Area under the estradiol time-concentration curve and peak estradiol level increased linearily and dose-proportionally with daily estradiol doses of 0.5-1.5 mg. This was shown by lack of significant differences in the dose-corrected parameters. However, the 90% confidence intervals between the doses were outside the commonly accepted levels for bioequivalence. Peak estradiol level was clearer and occurred earlier with the highest 1.5 mg estradiol dose, while more stable estradiol levels were seen with the lowest 0.5 mg estradiol dose. CONCLUSIONS:The amount of estradiol on a certain skin area seems to be the determining factor in absorption. With higher estradiol doses, the absorption will be accelerated with a clearer peak estradiol level. The linear and dose proportional absorption indicates that flexible dose adjustments within the dose range of 0.5-1.5 mg estradiol daily can be made with an anticipated effect in estradiol bioavailability and concentrations.
journal_name
Maturitasjournal_title
Maturitasauthors
Järvinen A,Granander M,Laine T,Viitanen Adoi
10.1016/s0378-5122(00)00101-8keywords:
subject
Has Abstractpub_date
2000-04-28 00:00:00pages
51-6issue
1eissn
0378-5122issn
1873-4111pii
S0378-5122(00)00101-8journal_volume
35pub_type
杂志文章相关文献
MATURITAS文献大全abstract::Serum oestrone, oestradiol and oestriol concentrations were investigated during oral treatment with oestradiol valerate and oestriol succinate in ovariectomized women. The dosages used were 1 mg oestradiol valerate in the morning and 2 mg oestriol succinate in the evening of the first day and 2 mg oestradiol valerate ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(78)90014-2
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVE:To analyze the effects of statin use on bone turnover markers (BTM), in participants from a large population-based cohort. SUBJECTS AND METHODS:Cross-sectional study that included 2431 subjects (1401 women and 930 men) from the Camargo Cohort. We analyzed the differences in serum BTM between statin or non-st...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.02.003
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:The menopause rating scale (MRS) has been developed as a modern tool for the assessment of menopausal complaints. It combines in practice excellent applicability and a good reliability, and there are normal values for the population available. For further practical evaluation, the MRS was applied in order to...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00177-8
更新日期:2000-12-29 00:00:00
abstract::Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and end...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(84)90065-3
更新日期:1984-07-01 00:00:00
abstract:OBJECTIVES:To examine the association between the principal lifetime occupation and the incidence of Alzheimer's disease (AD) in men and women in a southern European population aged 55 years or more. STUDY DESIGN:A community-dwelling sample of 3883 dementia-free individuals aged 55 years or over was classified accordi...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2019.05.008
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed. METHODS:Review of the relevant literature and results from recent clinical trials. RESULT...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2008.02.008
更新日期:2008-05-20 00:00:00
abstract:OBJECTIVES:To investigate the influence and specificity of sociodemographic and psychological factors on the perception of symptoms associated with menopause. STUDY DESIGN:Data are based on a nationwide cross-sectional survey study in Germany. A representative sample of 1350 females aged 14-95 years was examined. Soci...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.03.004
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate how whole-body vibration (WBV) and exercise and their interactions influenced leg muscle activity in elderly adults. STUDY DESIGN:An experimental study with repeated measures design that involved a group of ambulatory, community-dwelling elderly adults (n=30; 23 women; mean ag...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2016.03.011
更新日期:2016-06-01 00:00:00
abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(81)90003-7
更新日期:1981-08-01 00:00:00
abstract::The pentraxin serum amyloid P component (SAP) is a 9.5Sz1-glycoprotein and it has recently been found to be deposited in atherosclerotic lesions or neurofibrillary tangles, which are related to the aging process and Alzheimer's disease. The level of SAP was measured by micro single radial-immunodiffusion. Sample sera ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)01086-9
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of hormone replacement therapy (HT) use by postmenopausal women doctors and doctors' wives in Italy and to explore the relationship between their personal characteristics and HT use. DESIGN:A total of 500 women doctors and 500 men doctors answering on behalf of their female partner...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.10.008
更新日期:2006-05-20 00:00:00
abstract::The increased risk of breast cancer recently observed with some specific estro-progestin associations has raised concerns about the harmful effects of menopausal hormone replacement therapy (HRT). It has been proposed that phytoestrogens (PEs), which have a similar chemical structure to estrogens, could be used as HRT...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.07.001
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To examine the prevalence and correlates of foot problems in older women over a 6-year period. STUDY DESIGN:Women aged 70-75 years who participated in the Australian Longitudinal Study on Women's Health completed a postal questionnaire incorporating questions relating to demographics, major medical condition...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.08.010
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(00)00159-6
更新日期:2000-11-30 00:00:00
abstract:OBJECTIVES:The aim of this study was to observe hysterectomized postmenopausal women (without progestogen, which could interfere in the results), using oral-conjugated oestrogen 0.625 mg daily (n=13) or 17beta-estradiol transdermal patches delivering 50 microg daily (n=10) during 12 months, and to evaluate the treatmen...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/s0378-5122(03)00159-2
更新日期:2003-09-25 00:00:00
abstract::Serum and urine electrolytes, and biochemical indices of bone metabolism and liver function were measured in 51 post-menopausal women treated with two hormone replacement therapy regimens for 24 wk. Twenty-six of the women were treated continuously with conjugated equine oestrogens (0.625 mg/day) and the remainder wer...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(88)90100-4
更新日期:1988-03-01 00:00:00
abstract::Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(98)00056-5
更新日期:1998-09-20 00:00:00
abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.08.006
更新日期:2012-12-01 00:00:00
abstract::In order to assess the possible role of circulating immunoreactive inhibin (INH) during the menopausal transition, two groups of subjects were studied. Four were normal volunteers, three of whom had developed their first symptoms of cycle irregularity at age 45-46 years, the fourth being aged 37, a volunteer for a stu...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(93)90026-e
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.10.016
更新日期:2010-01-01 00:00:00
abstract::We investigated the long-term effects of oral estriol (E3) on bone mineral density (BMD) at the lumbar spine and biochemical indices of bone turnover in early menopausal women. We studied 64 healthy early menopausal women who were treated for 24 months with 2.0 mg E3 plus 2.5 mg medroxyprogesterone acetate daily (E3 g...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(97)00061-3
更新日期:1997-09-01 00:00:00
abstract::This study was a cross-sectional survey of mid-aged Thai women with the following aims: to describe their experience of symptoms and attitudes to menopause and to examine the relationships between symptoms, attitudes to menopause, sociodemographic variables and menopausal status. The sample was 268 women aged between ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)01058-4
更新日期:1997-01-01 00:00:00
abstract::Treatments for osteoporosis over the last few decades have largely focused on antiresorptive agents that effectively prevent bone loss. Beginning with hormone therapy, a variety of new potent antiresorptive agents were developed, including oral and intravenous bisphosphonates, raloxifene and other selective estrogen r...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2012.08.002
更新日期:2012-11-01 00:00:00
abstract::Earlier menopause onset has been linked to a greater risk of cardiovascular disease. Both menopause onset and cardiovascular disease risk vary by geographical region, race/ethnicity and socioeconomic status. As such, it is plausible to hypothesize that these factors may influence the association of menopause onset and...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2020.06.007
更新日期:2020-11-01 00:00:00
abstract::In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(02)00010-5
更新日期:2002-04-15 00:00:00
abstract::Most health decisions occur in contexts of scientific uncertainty, the "grey zone" of decision-making and many decisions faced by menopausal women are no exception. These contexts are characterized either by scientific evidence that points to a balance between harms and benefits within or between options, or by the ab...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.01.013
更新日期:2009-07-20 00:00:00
abstract::Elderly subjects with cognitive disorders are at particularly high risk of adverse drug reactions (ADRs). The objectives of our systematic review were to describe the prevalence of ADRs in elderly patients with cognitive disorders, the different types of ADRs and the medications suspected of involvement; to describe w...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.12.013
更新日期:2016-03-01 00:00:00
abstract::Tibolone (Livial) has advantages over other forms of hormone replacement therapy (HRT); it is easy to use and does not induce withdrawal bleeding in postmenopausal women. The evidence for the effect of tibolone on climacteric symptoms is reviewed and shows that tibolone is effective in reducing vasomotor symptoms and ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(94)00888-e
更新日期:1995-02-01 00:00:00
abstract::For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2016.05.015
更新日期:2016-09-01 00:00:00
abstract::Population health outcomes are shaped by complex interactions between individuals and the environments in which they live, work and play. Environments encompass streets and buildings (physical environment), attitudes, supports and relationships with others (social environment), as well as social and political systems ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.07.011
更新日期:2009-09-20 00:00:00