Abstract：
:The increased risk of breast cancer recently observed with some specific estro-progestin associations has raised concerns about the harmful effects of menopausal hormone replacement therapy (HRT). It has been proposed that phytoestrogens (PEs), which have a similar chemical structure to estrogens, could be used as HRT. The main selling points of these preparations concern the management of hot flashes and their potential beneficial effects on breast tissue. In this review, we will address the effects of PE on hot flashes and breast cancer risk as well as the questions raised on a chemical point of view. We conclude that the efficacy of a PE rich diet or nutritional supplements is not clearly established. The use of PE as an alternative for HRT cannot be advocated for now, due to insufficient and conflicting data on efficacy and safety. Moreover, due to the hormone dependence of breast cancer, PE use must be contraindicated in breast cancer survivors.
journal_name
Maturitasjournal_title
Maturitasauthors
This P,de Cremoux P,Leclercq G,Jacquot Ydoi
10.1016/j.maturitas.2011.07.001subject
Has Abstractpub_date
2011-11-01 00:00:00pages
222-6issue
3eissn
0378-5122issn
1873-4111pii
S0378-5122(11)00235-0journal_volume
70pub_type
杂志文章,评审相关文献
MATURITAS文献大全abstract：INTRODUCTION:Osteoporosis and its consequent fractures is a major public health problem. AIM:To formulate a position statement on the use of bone densitometry in screening postmenopausal women for osteoporosis and in their management. MATERIALS AND METHODS:Literature review and consensus of expert opinion. RESULTS A...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2010.09.009
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:Elevation of blood pressure and heart rate increase the risk of cardiovascular disease. Administration of estrogens does not affect heart rate but may decrease 24 h blood pressure. In this study, we tested the effect of the estro-progestogenic compound tibolone. METHODS:Thirty healthy, post-menopausal women ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.maturitas.2003.08.011
更新日期：2004-06-15 00:00:00
abstract：OBJECTIVES:Levonorgestrel (LNG), delivered locally into the uterine cavity has a profound effect on the endometrium. The aim of the study was to use a LNG intrauterine system to treat non-atypical and atypical endometrial hyperplasia in women and to evaluate the long-term cure (remission) rate. METHODS:Each of the 20 ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/j.maturitas.2006.12.004
更新日期：2007-06-20 00:00:00
abstract：:Telehealth offers a feasible method to provide nutrition support to malnourished older adults. This systematic review and meta-analysis aims to determine the efficacy of telehealth methods in delivering malnutrition-related interventions to community-dwelling older adults. Studies in any language were searched in five...
journal_title：Maturitas
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.maturitas.2018.02.012
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Develop a rat model for the evaluation of estrogenic agents on estrogen deficiency-induced changes in thermoregulation. METHODS:OVX rats are impaired in thermoregulation which manifests itself as an elevation in basal tail skin temperature (TST) and are less able to respond to temperature changes than intact...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2003.11.001
更新日期：2004-08-20 00:00:00
abstract：OBJECTIVE:To correlate circulating hormone levels with the clinical and biological features of the tumors in menopausal breast cancer patients. DESIGN:Circulating hormone levels were measured in 161 previously untreated menopausal breast cancer patients within 72 h of their planned surgery. The obtained hormone levels...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.07.001
更新日期：2009-09-20 00:00:00
abstract：OBJECTIVES:this paper aims to report the prevalence of symptoms in the Hong Kong Chinese perimenopausal women; to construct reported symptoms into symptom groupings; and to clarify whether the symptom groups are associated with menopausal status. METHODS:a random telephone survey of perimenopausal women aged 44-55 yea...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(99)00056-0
更新日期：1999-12-15 00:00:00
abstract：OBJECTIVE:Decision-making during menopause (especially surgical menopause) can be complex given the variability in risk-benefit perceptions of menopausal treatments. Decision aid tools (DATs) help women participate in decision-making about options. Our objective is to identify and evaluate the content and development o...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2017.09.006
更新日期：2017-12-01 00:00:00
abstract：:Fifty postmenopausal women requiring hormone replacement therapy for the treatment of climacteric symptoms were recruited in six centers. All patients received a new combined norethisterone acetate (NETA)/oestradiol (E2)-TTS, (Estragest TTS, Ciba-Geigy Ltd), delivering 0.25 mg NETA and 50 micrograms E2 per day, contin...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0378-5122(94)00891-a
更新日期：1995-04-01 00:00:00
abstract：:Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the lit...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2019.08.006
更新日期：2019-11-01 00:00:00
abstract：:Osteoarthritis (OA) is a common age-related disease that affects the tissues of the synovial joint, leading to loss of function and pain. It impacts on both patient morbidity and mortality. It is a complex, polygenic disease that lacks any large-effect susceptibility loci. Instead, OA susceptibility alleles individual...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.12.001
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the association between treatments for vulvovaginal atrophy (VVA) and symptom frequency and severity, quality of life (QoL) and sexual functioning in postmenopausal women. STUDY DESIGN:Cross-sectional survey conducted in postmenopausal women aged 45-75 years. Data on demographic and clinical var...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2019.03.013
更新日期：2019-06-01 00:00:00
abstract：:The effect of two forms of exogenous estrogen and a placebo on diastolic blood pressure and bodyweight was evaluated in 50 oophorectomized women. There was no significant change in bodyweight on any form of treatment, nor was there any significant elevation in mean diastolic blood pressure. However, 2 out of 49 female...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(78)90003-8
更新日期：1978-06-01 00:00:00
abstract：:Examining such terms as climacteric or menopause and utilizing supportive historical data, an attempt is made to trace the development of these concepts, their time of inception and their spread. It is suggested that the persistence of popular terminology of the climacteric, especially in England, until late in the la...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(81)90013-x
更新日期：1981-03-01 00:00:00
abstract：:In the present study, unopposed oestrogens were given to 184 non-hysterectomized women, for a duration varying from four weeks to 24 months, while the endometrial responses were monitored by transvaginal sonography (TVS) and backed up by endometrial sampling (conducted when the endometrial thickness reached 8 mm (doub...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(96)00995-4
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To study the efficacy and tolerability of Aerodiol, a novel intranasal estradiol spray, and to determine an appropriate dose range. METHODS:An exploratory, parallel-group, dose-finding study was followed by a large-scale, double-blind, placebo-controlled study. In the exploratory study, 134 postmenopausal wo...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(01)00200-6
更新日期：2001-06-15 00:00:00
abstract：INTRODUCTION:Osteoporotic vertebral fractures are associated with significant morbidity, excess mortality as well as health and social service expenditure. Additionally, women with a prevalent osteoporotic vertebral fracture have a high risk of experiencing a further one within one year. It is therefore important for t...
journal_title：Maturitas
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.maturitas.2014.03.002
更新日期：2014-06-01 00:00:00
abstract：:The aim of this trial was to study the vaginal absorption of oestriol and to investigate whether morning rather than evening oestriol administration would produce different plasma oestriol patterns. The influence of food intake on plasma oestriol levels was also investigated. Nine post-menopausal women were given 0.5 ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(86)90031-9
更新日期：1986-10-01 00:00:00
abstract：:The reduction of gonadotrophin levels, urinary calcium and hot flushes in post-menopausal patients by ethinyl oestradiol is shown to be dose dependent, near maximum response being achieved by a dose of 15 micrograms daily. Equivalent ethinyl oestradiol doses to a number of other gonadal hormone preparations have been ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90060-3
更新日期：1982-12-01 00:00:00
abstract：OBJECTIVES:To investigate the influence and specificity of sociodemographic and psychological factors on the perception of symptoms associated with menopause. STUDY DESIGN:Data are based on a nationwide cross-sectional survey study in Germany. A representative sample of 1350 females aged 14-95 years was examined. Soci...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2020.03.004
更新日期：2020-06-01 00:00:00
abstract：:The endometrial effect of long-term vaginal oestriol (E3) therapy for urogenital atrophy was assessed in 23 post-menopausal women. Hysteroscopic and histological examinations were performed in each patient to assess endometrial atrophy before treatment and after 6 and 12 months of therapy (0.5 mg vaginal E3 for 21 day...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(91)90235-i
更新日期：1991-10-01 00:00:00
abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(94)00855-2
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00921-7
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:We investigated, using color Doppler ultrasound, possible detectable blood changes of prolonged treatment with 17-beta-estradiol tablets on uterine artery blood flow, in a cohort of low risk postmenopausal women. METHODS:39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, w...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.07.004
更新日期：2005-04-11 00:00:00
abstract：:Epidemiological studies have shown that cigarette smoking is associated with an increased risk of midlife hot flashes; however, the effect of quitting smoking on this risk is unclear. The purpose of this study was to examine the effect of quitting smoking on hot flashes using data from 761 women aged 45 to 54 years of...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.06.029
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.008
更新日期：2007-01-20 00:00:00
abstract：OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2005.01.002
更新日期：2006-01-10 00:00:00
abstract：:From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 1...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2008.09.010
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0378-5122(03)00279-2
更新日期：2004-03-15 00:00:00
abstract：:There are few prospective data on temporal trends in overall sitting time for different domains of sitting. This study examined time trends over 6 years in total and domain-specific sitting time in mid-age Australian men and women. Self-report data from 5246 participants in four survey waves (2007, 2009, 2011, 2013) o...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.08.006
更新日期：2018-10-01 00:00:00
