Current perspectives on the benefits of HRT in menopausal women.

Abstract:

AIMS:Women in the West can now expect to live one third of their life in a postmenopausal state, and consequently in a state of estrogen deficiency. This can have a number of consequences, and many women suffer vasomotor symptoms during the climacteric. Estrogen deficiency can also result in changes to the skin, hair, urogenital, cardiovascular and skeletal systems. This article reviews some of the main actions of replacement estrogen in postmenopausal women, and discusses the major benefits of estrogen replacement therapy (ERT) and hormone replacement therapy (HRT). REVIEW:HRT is well documented to reduce vasomotor symptoms in women suffering from estrogen deficiency, and can have beneficial effects on the skin and the prevention of skin aging. HRT has beneficial effects on urogenitary function including reductions in urinary incontinence and vaginal atrophy. HRT is used as a first-line treatment to prevent or reverse the development of postmenopausal osteoporosis and can reduce the risk of fractures if taken for 5-10 years from the menopause. In epidemiological studies, ERT was associated with a reduction in the risk of coronary heart disease. Estrogens seem to affect the cardiovascular system directly and indirectly such as reducing some of the coronary risk factors. In recent years, estrogen has been linked to beneficial effects in the CNS including an association with a reduction in the risk of developing Alzheimer's Disease. Despite these benefits, HRT compliance remains low, and physicians need to address this if patients are to gain the benefits.

journal_name

Maturitas

journal_title

Maturitas

authors

Palacios S

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

S1-13

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(99)00058-4

journal_volume

33 Suppl 1

pub_type

杂志文章,评审
  • Increased menopausal symptoms among Afro-Colombian women as assessed with the Menopause Rating Scale.

    abstract:BACKGROUND:Increased frequency and severity of menopausal symptoms have been associated to black race. However, this situation has not been described in any Latin American population. OBJECTIVE:Compare frequency and severity of menopausal symptoms among Afro and non-Afro Hispanic Colombian climacteric women. METHODS:...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.12.002

    authors: Monterrosa A,Blumel JE,Chedraui P

    更新日期:2008-02-20 00:00:00

  • Multiple myeloma: Current and future management in the aging population.

    abstract::The increasing lifespan of the world population and the novel therapeutic combinations for the treatment of multiple myeloma (MM), which are more efficacious and safer, make the question of how to manage the older patient with MM increasingly relevant. Clinical trial data come mostly from subgroup analysis, as no clin...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2020.04.015

    authors: Fotiou D,Ntanasis-Stathopoulos I,Gavriatopoulou M,Dimopoulos MA

    更新日期:2020-08-01 00:00:00

  • Genetics and epigenetics of osteoarthritis.

    abstract::Osteoarthritis (OA) is a common age-related disease that affects the tissues of the synovial joint, leading to loss of function and pain. It impacts on both patient morbidity and mortality. It is a complex, polygenic disease that lacks any large-effect susceptibility loci. Instead, OA susceptibility alleles individual...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2011.12.001

    authors: Reynard LN,Loughlin J

    更新日期:2012-03-01 00:00:00

  • Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT.

    abstract:OBJECTIVES:Our pilot study tested the efficacy, acceptability and tolerability of DHA supplementation in addition to calcium and vitamin D in individuals with osteopenia. STUDY DESIGN:40 participants were randomised to either algal oil containing 400mg docosahexanoic acid (DHA) daily or placebo. All participants recei...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2011.10.004

    authors: Vanlint SJ,Ried K

    更新日期:2012-01-01 00:00:00

  • Predictive ability and reliability of the STOP-BANG questionnaire in screening for obstructive sleep apnea in midlife women.

    abstract:OBJECTIVES:The STOP-BANG questionnaire (snoring, tiredness, observed apneas, high blood pressure, body mass index, age, neck size, gender) was originally validated to screen for obstructive sleep apnea (OSA) in the surgical population. It has been validated in mixed populations of men and women. We aimed to evaluate it...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2020.02.004

    authors: Orbea CAP,Lloyd RM,Faubion SS,Miller VM,Mara KC,Kapoor E

    更新日期:2020-05-01 00:00:00

  • The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis.

    abstract:OBJECTIVE:The activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis. METHODS:Utilizing a cohort of 39 postmenopausa...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2012.03.014

    authors: Schnatz PF,Nudy M,O'Sullivan DM,Jiang X,Cline JM,Kaplan JR,Clarkson TB,Appt SE

    更新日期:2012-10-01 00:00:00

  • Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. The HIPERPROT-GER study.

    abstract:INTRODUCTION:Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. METHODS:A prospective randomized...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2013.06.016

    authors: Malafarina V,Uriz-Otano F,Gil-Guerrero L,Iniesta R,Zulet MA,Martinez JA

    更新日期:2013-10-01 00:00:00

  • Moderate-severely bothersome vasomotor symptoms are associated with lowered psychological general wellbeing in women at midlife.

    abstract:OBJECTIVES:The extent to which menopause influences wellbeing is unclear. We investigated the association between moderate-severely bothersome vasomotor symptoms (VMS) and psychological general wellbeing in women, aged 40-65 years, taking into account socio-demographic and lifestyle factors. STUDY DESIGN/MAIN OUTCOME ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.06.004

    authors: Gartoulla P,Bell RJ,Worsley R,Davis SR

    更新日期:2015-08-01 00:00:00

  • The attitude of gynecologists in São Paulo, Brazil 3 years after the Women's Health Initiative study.

    abstract:OBJECTIVE:The objective of this study was to evaluate gynecologists' knowledge of the WHI study, and its repercussions on their attitudes and practice 3 years after publication. DESIGN:A self-administered, anonymous questionnaire containing 19 questions was sent to 6000 gynecologists, members of the São Paulo Society ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.06.022

    authors: Lazar F Jr,Costa-Paiva L,Morais SS,Pedro AO,Pinto-Neto AM

    更新日期:2007-02-20 00:00:00

  • The effect of occupation type on risk of Alzheimer's disease in men and women.

    abstract:OBJECTIVES:To examine the association between the principal lifetime occupation and the incidence of Alzheimer's disease (AD) in men and women in a southern European population aged 55 years or more. STUDY DESIGN:A community-dwelling sample of 3883 dementia-free individuals aged 55 years or over was classified accordi...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2019.05.008

    authors: Santabárbara J,Gracía-Rebled AC,López-Antón R,Tomás C,Lobo E,Marcos G,Lobo A

    更新日期:2019-08-01 00:00:00

  • The effects of postmenopausal Vitamin D treatment on vaginal atrophy.

    abstract:OBJECTIVES:To evaluate the efficacy of Vitamin D for relieving vaginal atrophy. METHODS:In our cross-sectional study, 60 eligible women were consecutively identified among patients who were followed in physical medicine and rehabilitation's outpatient clinic, during the period March June 2001. The sample consisted of ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2004.02.008

    authors: Yildirim B,Kaleli B,Düzcan E,Topuz O

    更新日期:2004-12-10 00:00:00

  • Classical and newly recognised non-contraceptive benefits of combined hormonal contraceptive use in women over 40.

    abstract::Although age is the most crucial predictor of a woman's reproductive capacity, it is assumed that there is still a risk of pregnancy in menopause transition, as occasional spontaneous ovulation is possible. Moreover, age alone is not sufficient to contraindicate the use of any contraceptive method, whether hormonal or...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.02.017

    authors: Mendoza N,Sanchez-Borrego R

    更新日期:2014-05-01 00:00:00

  • Efficacy and effectiveness of bulking agents in the treatment of stress and mixed urinary incontinence: A systematic review and meta-analysis.

    abstract::The objective of this systematic review and meta-analysis was to evaluate the efficacy and the effectiveness, as well as the safety and tolerability, of urethral bulking agents (UBAs) in women with mixed or stress urinary incontinence. PubMed, Scopus, and the Cochrane Central Register of Controlled Trials were used to...

    journal_title:Maturitas

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.maturitas.2019.12.007

    authors: Capobianco G,Saderi L,Dessole F,Petrillo M,Dessole M,Piana A,Cherchi PL,Dessole S,Sotgiu G

    更新日期:2020-03-01 00:00:00

  • Aromatherapy for stress reduction in healthy adults: a systematic review and meta-analysis of randomized clinical trials.

    abstract::The aim of this review was to systematically assess the effectiveness of aromatherapy for stress management. Seven databases were searched from their inception through April 2014. RCTs testing aromatherapy against any type of controls in healthy human person that assessed stress level and cortisol level were considere...

    journal_title:Maturitas

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.maturitas.2014.08.006

    authors: Hur MH,Song JA,Lee J,Lee MS

    更新日期:2014-12-01 00:00:00

  • Factors affecting bone loss around menopause in women without HRT: a prospective study.

    abstract:OBJECTIVES:The present study evaluated the effects of menopause and other putative bone loss modifying factors on bone mineral density (BMD) change. METHODS:The study population, 396 healthy women aged 48-59 years with no history of hormone replacement therapy (HRT) use or any bone affecting disease or medications, wa...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(03)00150-6

    authors: Sirola J,Kröger H,Honkanen R,Jurvelin JS,Sandini L,Tuppurainen MT,Saarikoski S,OSTPRE Study Group.

    更新日期:2003-07-25 00:00:00

  • Clinical profile of Org OD 14.

    abstract::The clinical profile of Org OD 14 ((7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5 (10)-en-20-yn-3-one) is remarkable in that the compound demonstrates simultaneous weak oestrogenic, androgenic and progestational activity after oral administration to animals. It was therefore studied to evaluate its efficacy in t...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/0378-5122(87)90038-7

    authors: Tax L,Goorissen EM,Kicovic PM

    更新日期:1987-01-01 00:00:00

  • Postmenopausal hormone therapy and mammographic breast density.

    abstract:OBJECTIVE:The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS:In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die ...

    journal_title:Maturitas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.maturitas.2005.02.010

    authors: Marchesoni D,Driul L,Ianni A,Fabiani G,Della Martina M,Zuiani C,Bazzocchi M

    更新日期:2006-01-10 00:00:00

  • Molecular aspects of skin ageing.

    abstract::Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2011.04.011

    authors: Naylor EC,Watson RE,Sherratt MJ

    更新日期:2011-07-01 00:00:00

  • Thyrotropin-releasing hormone and the menopausal hot flash.

    abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/0378-5122(81)90003-7

    authors: Molnar GW

    更新日期:1981-08-01 00:00:00

  • Personal and professional use of menopausal hormone therapy among gynecologists: A multinational study (REDLINC VII).

    abstract:BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...

    journal_title:Maturitas

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.maturitas.2016.02.015

    authors: Danckers L,Blümel JE,Witis S,Vallejo MS,Tserotas K,Sánchez H,Salinas C,Saavedra J,Rojas JA,Onatra W,Ojeda E,Mostajo D,Morera F,Monterrosa A,Montaño A,Meruvia N,Martino M,Martínez J,Lima S,González E,Gómez G,Espi

    更新日期:2016-05-01 00:00:00

  • Stem cells and the reproductive system: historical perspective and future directions.

    abstract::Recent findings in stem cell biology have presented new perspectives and opportunities for the treatment of reproductive disease. In a departure from the long held dogma of embryologically fixed numbers of oocytes, current literature suggests that human ovaries contain stem cells which form new oocytes even in adultho...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2013.08.012

    authors: Duke CM,Taylor HS

    更新日期:2013-11-01 00:00:00

  • The effects of a soy rich diet on serum lipids: the Menfis randomized trial.

    abstract:OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(01)00259-6

    authors: Chiechi LM,Secreto G,Vimercati A,Greco P,Venturelli E,Pansini F,Fanelli M,Loizzi P,Selvaggi L

    更新日期:2002-02-26 00:00:00

  • Breast cancer molecular subtypes--modern therapeutic concepts for targeted therapy of a heterogeneous entity.

    abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2012.08.006

    authors: Liedtke C,Kiesel L

    更新日期:2012-12-01 00:00:00

  • Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels.

    abstract::This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly mens...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(93)90120-7

    authors: Gonzales GF,Carrillo C

    更新日期:1993-07-01 00:00:00

  • The prescription of hormone replacement therapy in Spain: differences between general practitioners and gynaecologists.

    abstract:OBJECTIVES:The purpose of this study was to determine the frequency with which hormone replacement therapy (HRT) was prescribed and to identify physician-related factors associated with the prescription of HRT in Spain. STUDY DESIGN:A descriptive cross-sectional survey based on a personal interview with a structured q...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.04.023

    authors: Castelo-Branco C,Ferrer J,Palacios S,Cornago S

    更新日期:2006-11-20 00:00:00

  • Reporting of sex-specific outcomes in trials of interventions for cardiovascular disease: Has there been progress?

    abstract::In the past decade, the leading international cardiology societies have released statements that emphasize the importance of sex-specific reporting of the findings of clinical trials in cardiovascular research. To find out whether this has led to improvement, we compared sex-specific reporting of efficacy and safety o...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2020.09.007

    authors: Schreuder MM,Boersma E,Kavousi M,Visser LE,Roos-Hesselink JW,Versmissen J,Roeters van Lennep JE

    更新日期:2021-02-01 00:00:00

  • Clinical evaluation, dose-finding and acceptability of AERODIOL, the pulsed estrogen therapy for treatment of climacteric symptoms.

    abstract::S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0378-5122(00)00175-4

    authors: Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime B

    更新日期:2001-01-31 00:00:00

  • Effect of physical training on age-related reduction of GH secretion during exercise in normally cycling women.

    abstract:OBJECTIVE:To evaluate whether prolonged physical activity (25 km/week running for 8 years) modifies GH decline. DESIGN:The GH response to maximal exercise on bicycle-ergometer was tested in younger (26-30 years) and older (42-46 years) healthy women. Each age group included 2 subgroups of 10 sedentary and 10 runners, ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2009.12.020

    authors: Coiro V,Volpi R,Gramellini D,Maffei ML,Volta E,Melani A,Chiodera P

    更新日期:2010-04-01 00:00:00

  • Frailty and multimorbidity: Two related yet different concepts.

    abstract::The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2016.10.008

    authors: Villacampa-Fernández P,Navarro-Pardo E,Tarín JJ,Cano A

    更新日期:2017-01-01 00:00:00

  • The impact of a monophasic continuous estro-progestogenic treatment on Latin American menopausal women.

    abstract:OBJECTIVE:The present study was undertaken to assess the impact, effectiveness and safety of a monophasic hormone replacement treatment (HRT) for continuous use with regards to the clinical effects, bleeding patterns and lipid profile of menopausal women in four Latin American countries. DESIGN:Three hundred and six p...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.maturitas.2004.05.014

    authors: Bassol S,Carranza-Lira S,Celis-Gonzalez C,Santoyo S,Murillo A,Martinez N,Santos J,Llaca V,de la Loza FR,Zarain J,da Fonseca AM,Camargos AF,Baracat EC,da Sá MF,Bayo J,Adaro L,Gurucharri C,Murga M,Siseles N,Sayegh F,

    更新日期:2005-03-14 00:00:00