当前位置： SCI文献检索 > MATURITAS期刊下所有文献 > Aromatase inhibitors and the endometrium.

Aromatase inhibitors and the endometrium.

Abstract：

OBJECTIVE:To investigate the potential impact of aromatase inhibitors, given after stopping tamoxifen treatment, on the endometrium of postmenopausal breast cancer patients. METHODS:Review of all available literature of studies on aromatase inhibitor therapy in postmenopausal breast cancer patients previously treated with tamoxifen. RESULTS:(1) Endometrial thickness was found to be significantly lower in patients switched from tamoxifen treatment to aromatase inhibitor therapy, compared to those who continued tamoxifen treatment. This significant difference between the 2 groups was maintained throughout the entire treatment. (2) Vaginal bleeding was significantly more common in patients who continued tamoxifen therapy as compared to those who switched to aromatase inhibitors. (3) Replacement of tamoxifen treatment by aromatase inhibitors in postmenopausal breast cancer patients resulted in the appearance of only few, benign endometrial pathologies. The different endometrial pathologies were more common in patients who continued tamoxifen therapy, compared to patients who switched to aromatase inhibitors. (4) Endometrial cancer was recovered in significantly more patients who continued tamoxifen therapy as compared to those switched to aromatase inhibitors. However, some studies showed no significant statistical differences in the frequency of endometrial cancer diagnosed in the tamoxifen group as compared to the aromatase inhibitor group. CONCLUSION:These findings may hint on the possibility that aromatase inhibitors may provide a potential protective effect on the endometrium in patients previously treated with tamoxifen.

journal_name

Maturitas

journal_title

Maturitas

authors

Cohen I

doi

10.1016/j.maturitas.2008.03.001

subject

Has Abstract

pub_date

2008-04-20 00:00:00

pages

285-92

issue

4

eissn

0378-5122

issn

1873-4111

pii

S0378-5122(08)00075-3

journal_volume

59

pub_type

杂志文章,评审

相关文献

MATURITAS文献大全
  • Evaluating risk factors for differences in fibroid size and number using a large electronic health record population.

    abstract：OBJECTIVE:To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS:This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and ...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2018.05.003

    authors： Bray MJ,Torstenson ES,Jones SH,Edwards TL,Velez Edwards DR

    更新日期：2018-08-01 00:00:00

  • Reporting of sex-specific outcomes in trials of interventions for cardiovascular disease: Has there been progress?

    abstract：:In the past decade, the leading international cardiology societies have released statements that emphasize the importance of sex-specific reporting of the findings of clinical trials in cardiovascular research. To find out whether this has led to improvement, we compared sex-specific reporting of efficacy and safety o...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2020.09.007

    authors： Schreuder MM,Boersma E,Kavousi M,Visser LE,Roos-Hesselink JW,Versmissen J,Roeters van Lennep JE

    更新日期：2021-02-01 00:00:00

  • Lack of microbial proliferation and phototoxic potential of a new matrix patch for estradiol delivery.

    abstract：OBJECTIVES:To examine the potential of a new matrix system developed for estradiol delivery to cause microbial proliferation under the occluded site or to cause acute phototoxicity reactions. METHODS:Twenty healthy post-menopausal women participated in a microbial proliferation study and 11 in a phototoxicity study. B...

    journal_title：Maturitas

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0378-5122(96)01062-6

    authors： Mulberry GK,Della-Cioppa G,Monza G,Harper RA,Oelrich DM

    更新日期：1996-11-01 00:00:00

  • Predictors and persistence of foot problems in women aged 70 years and over: a prospective study.

    abstract：OBJECTIVE:To examine the prevalence and correlates of foot problems in older women over a 6-year period. STUDY DESIGN:Women aged 70-75 years who participated in the Australian Longitudinal Study on Women's Health completed a postal questionnaire incorporating questions relating to demographics, major medical condition...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2010.08.010

    authors： Menz HB,Barr EL,Brown WJ

    更新日期：2011-01-01 00:00:00

  • A prospective study of the frequency of acute menopausal symptoms in Hong Kong Chinese women.

    abstract：:A prospective study was conducted amongst Hong Kong Chinese women to determine the incidence of acute menopausal symptoms following surgical menopause. Cases where a laparotomy was performed for other indications were used as controls. Hot flushes and sweating developed in 8/33 (24.2%) and 6/33 (18.2%), respectively, ...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/0378-5122(94)90123-6

    authors： Haines CJ,Chung TK,Leung DH

    更新日期：1994-03-01 00:00:00

  • The age and symptomatology of natural menopause among United Arab Emirates women.

    abstract：OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/s0378-5122(98)00010-3

    authors： Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

    更新日期：1998-06-17 00:00:00

  • Treatment with percutanous testosterone gel in postmenopausal women with decreased libido--effects on sexuality and psychological general well-being.

    abstract：OBJECTIVES:To elucidate if percutanous treatment with 10mg testosterone per day could enhance sexuality and psychological well-being in postmenopausal women presenting problems with low libido. Secondary to study the influence on blood lipids, hemoglobin and erythropoietin levels. METHODS:Fifty-three postmenopausal wo...

    journal_title：Maturitas

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.maturitas.2005.01.002

    authors： Nathorst-Böös J,Flöter A,Jarkander-Rolff M,Carlström K,Schoultz Bv

    更新日期：2006-01-10 00:00:00

  • A systematic review of social support interventions for caregivers of people with dementia: Are they doing what they promise?

    abstract：OBJECTIVE:Social support interventions for caregivers of persons with dementia (PwD) are important because informal carers often rely on their social networks for support. This systematic review synthesises findings from research on social support interventions, and examines their methodological quality and effectivene...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2015.12.008

    authors： Dam AE,de Vugt ME,Klinkenberg IP,Verhey FR,van Boxtel MP

    更新日期：2016-03-01 00:00:00

  • Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia.

    abstract：OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and ...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2007.10.002

    authors： Pereira LC,Pereira FA,Sá MF,Foss MC,de Paula FJ

    更新日期：2008-01-20 00:00:00

  • Age-related bone loss and sarcopenia in men.

    abstract：:Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This occurs in both genders but compared with postmenopausal women, men a...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2019.01.006

    authors： Laurent MR,Dedeyne L,Dupont J,Mellaerts B,Dejaeger M,Gielen E

    更新日期：2019-04-01 00:00:00

  • Observational and mechanistic links between C-reactive protein and blood pressure in elderly women.

    abstract：:It is hypothesized that chronic systemic inflammation contributes to the age-related decline in cardiovascular function. The aim of the present study was to combine an assessment of the relationship between the serum level of C-reactive protein (CRP) and systolic and diastolic blood pressure in 108 elderly women (65 a...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2016.04.016

    authors： Hosford-Donovan A,Nilsson A,Wåhlin-Larsson B,Kadi F

    更新日期：2016-07-01 00:00:00

  • Expression of estrogen receptor (ER) in oral mucosa and salivary glands.

    abstract：OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/s0378-5122(00)00138-9

    authors： Leimola-Virtanen R,Salo T,Toikkanen S,Pulkkinen J,Syrjänen S

    更新日期：2000-08-31 00:00:00

  • Ophthalmic complaints as a climacteric symptom.

    abstract：:The menopausal syndrome is characterized by a variety of emotional and physical symptoms of varying intensity. A total of 1287 women who attended the Outpatient Department for Climacteric Symptoms and Osteoporosis Prophylaxis (1st Department of Gynaecology and Obstetrics, University of Vienna Medical School) constitut...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/0378-5122(91)90141-c

    authors： Metka M,Enzelsberger H,Knogler W,Schurz B,Aichmair H

    更新日期：1991-12-01 00:00:00

  • Prevalence of disability and associated social and health-related factors among the elderly in Spain: a population-based study.

    abstract：OBJECTIVES:To estimate the prevalence of disability and its association with morbidity and other social and health-related factors among Spain's non-institutionalized elderly population. METHODS:Cross-sectional survey, by home-based personal interview, covering a sample of 4000 subjects representative of the non-insti...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2003.10.004

    authors： Graciani A,Banegas JR,López-García E,Rodríguez-Artalejo F

    更新日期：2004-08-20 00:00:00

  • Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk.

    abstract：OBJECTIVES:Assessing the combined impact of mutation position, regarding the ovarian cancer cluster region (OCCR), and type of cancer family history (FH) on age-related penetrance of ovarian cancer (OC) in women from BRCA1/2 families from the northern Netherlands. STUDY DESIGN:A consecutive series of 1763 mutation car...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2015.07.001

    authors： Teixeira N,Mourits MJ,Vos JR,Kolk DM,Jansen L,Oosterwijk JC,Bock GH

    更新日期：2015-10-01 00:00:00

  • Vitamin D and its implications for musculoskeletal health in women: an update.

    abstract：:Vitamin D is a hormone that controls phosphorus, calcium, and bone metabolism and neuromuscular function. Vitamin D synthesis is a process in which the skin, liver, and kidney are sequentially involved. The vitamin D pool is completed by the amount taken with food and supplements. Vitamin D deficiency causes osteopeni...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2007.05.002

    authors： Pérez-López FR

    更新日期：2007-10-20 00:00:00

  • Position of the Spanish Menopause Society regarding the management of menopausal symptoms in breast cancer patients.

    abstract：:Breast cancer is the most common female cancer in Spain. Its high prevalence, its high survival rate, and its incidence are the reasons treatment is increasingly sought for common problems by young women who have survived it. Besides the contraception and fertility issues, many breast cancer survivors develop sexual d...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2013.04.016

    authors： Sánchez-Borrego R,Mendoza N,Beltrán E,Comino R,Allué J,Castelo-Branco C,Cornellana MJ,Duran M,Haya J,Juliá MD,Llaneza P,Navarro MC,Quereda F

    更新日期：2013-07-01 00:00:00

  • The effect of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats.

    abstract：OBJECTIVE:The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. METHODS:Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiti...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/s0378-5122(02)00068-3

    authors： Kuşcu NK,Koyuncu FM,Inan S,Tuglu I,Uyar Y,Ozbilgin K

    更新日期：2002-07-25 00:00:00

  • Dose proportionality study of four doses of an estradiol transdermal system, Estradot.

    abstract：OBJECTIVES:To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot, in healthy postmenopausal women and to evaluate the wear and irritation properties of the ETS. METHODS:In an open label, single-dose, randomized, four-period crossover study, healthy postmenopausal wome...

    journal_title：Maturitas

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0378-5122(03)00189-0

    authors： Hossain M,Quebe-Fehling E,Sergejew T,Schmidt G,Skerjanec A,Ibarra de Palacios P,Krinsky L

    更新日期：2003-11-20 00:00:00

  • Administration of tibolone decreases 24 h heart rate but not blood pressure of post-menopausal women.

    abstract：OBJECTIVE:Elevation of blood pressure and heart rate increase the risk of cardiovascular disease. Administration of estrogens does not affect heart rate but may decrease 24 h blood pressure. In this study, we tested the effect of the estro-progestogenic compound tibolone. METHODS:Thirty healthy, post-menopausal women ...

    journal_title：Maturitas

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.maturitas.2003.08.011

    authors： Cagnacci A,Baldassari F,Arangino S,Alessandrini C,Volpe A

    更新日期：2004-06-15 00:00:00

  • Endocrinological and clinical investigations in post-menopausal women following administration of vaginal cream containing oestriol.

    abstract：:The maturation value (MV), cervical mucus parameters (ferning, Spinnbarkeit), oestrone (E1), oestradiol (E2), oestriol (E3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyrotropin (TSH), growth hormone (GH), sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG) ...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/0378-5122(81)90041-4

    authors： Haspels AA,Luisi M,Kicovic PM

    更新日期：1981-12-01 00:00:00

  • Management of patients with non-atypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: long-term follow-up.

    abstract：OBJECTIVES:Levonorgestrel (LNG), delivered locally into the uterine cavity has a profound effect on the endometrium. The aim of the study was to use a LNG intrauterine system to treat non-atypical and atypical endometrial hyperplasia in women and to evaluate the long-term cure (remission) rate. METHODS:Each of the 20 ...

    journal_title：Maturitas

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.maturitas.2006.12.004

    authors： Wildemeersch D,Janssens D,Pylyser K,De Wever N,Verbeeck G,Dhont M,Tjalma W

    更新日期：2007-06-20 00:00:00

  • Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women.

    abstract：OBJECTIVE:New regimens and routes of administration of hormonal replacement therapy (HRT) in climateric women are becoming available. Since there is no information on the neuroendocrine effects of sequential combined treatment with 17 beta-estradiol and a progestin, the present study evaluated the neuroendocrine, clini...

    journal_title：Maturitas

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0378-5122(97)00073-x

    authors： Stomati M,Bersi C,Rubino S,Palumbo M,Comitini G,Genazzani AD,Santuz M,Petraglia F,Genazzani AR

    更新日期：1997-12-15 00:00:00

  • Cardiovascular disease prevention in women: Impact of dietary interventions.

    abstract：:In Western countries, cardiovascular disease is the leading cause of death in women. Prevalence of risk factors and clinical presentation are different in men and women and it is important to take these differences into account in both prevention and treatment. A healthy diet can substantially reduce cardiovascular ri...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2009.02.003

    authors： Hoekstra T,Beulens JW,van der Schouw YT

    更新日期：2009-05-20 00:00:00

  • Tibolone: a review.

    abstract：:Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-5122(98)00059-0

    authors： Albertazzi P,Di Micco R,Zanardi E

    更新日期：1998-11-16 00:00:00

  • An integrative review on current evidence of testosterone replacement therapy for the andropause.

    abstract：OBJECTIVES:This paper examines the evidence supporting testosterone replacement in aging males. Confounding factors contributing to low testosterone levels and challenges to diagnosis of the andropause will also be considered. METHODS:A thorough review using an integrative approach citing published literature and the ...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/s0378-5122(03)00083-5

    authors： Tan RS,Culberson JW

    更新日期：2003-05-30 00:00:00

  • Quality of life, characteristics and metabolic control in diabetic geriatric patients.

    abstract：OBJECTIVES:To describe the characteristics, metabolic control and health-related quality of life (HRQL) of type 2 diabetes mellitus (T2DM) geriatric patients. STUDY DESIGN:Cross-sectional descriptive study of consecutive patients attended at a geriatric outpatient clinic in a tertiary hospital over three months. Socio...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2011.05.001

    authors： Rodríguez-Pascual C,Rodriguez-Justo S,García-Villar E,Narro-Vidal M,Torrente-Carballido M,Paredes-Galan E

    更新日期：2011-08-01 00:00:00

  • A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density.

    abstract：:From a longitudinal prospective study, 160 women with spontaneous menopause and without steroid medication were followed during the transition from pre- to postmenopause. After 12 years 152 women were still participating in the study. Blood samples were drawn every 6 months until 1 year after the menopause and every 1...

    journal_title：Maturitas

    pub_type： 杂志文章

    doi：10.1016/j.maturitas.2008.09.010

    authors： Rannevik G,Jeppsson S,Johnell O,Bjerre B,Laurell-Borulf Y,Svanberg L

    更新日期：2008-09-01 00:00:00

  • Molecular aspects of skin ageing.

    abstract：:Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2011.04.011

    authors： Naylor EC,Watson RE,Sherratt MJ

    更新日期：2011-07-01 00:00:00

  • The role of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women.

    abstract：:At least 16 million women over the age of 50 currently experience low sexual desire, with approximately 4 million women exhibiting hypoactive sexual desire disorder (HSDD). Although early research established that testosterone therapy improves sexual desire in postmenopausal women, safer and more efficacious administr...

    journal_title：Maturitas

    pub_type： 杂志文章,评审

    doi：10.1016/j.maturitas.2009.04.008

    authors： Krapf JM,Simon JA

    更新日期：2009-07-20 00:00:00