Dose proportionality study of four doses of an estradiol transdermal system, Estradot.

abstract：OBJECTIVES:To develop a condition-specific quality of life (QoL) questionnaire to assess the symptoms of the decline in testosterone that occurs as men age, otherwise known as the andropause. METHODS:Two focus groups of patients with low testosterone levels and an expert panel of physicians in the treatment of male te...

journal_title：Maturitas

authors： Novák A,Brod M,Elbers J

更新日期：2002-12-10 00:00:00

abstract：:S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...

journal_title：Maturitas

authors： Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime B

更新日期：2001-01-31 00:00:00

abstract：:At least 16 million women over the age of 50 currently experience low sexual desire, with approximately 4 million women exhibiting hypoactive sexual desire disorder (HSDD). Although early research established that testosterone therapy improves sexual desire in postmenopausal women, safer and more efficacious administr...

journal_title：Maturitas

authors： Krapf JM,Simon JA

更新日期：2009-07-20 00:00:00

abstract：OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...

journal_title：Maturitas

authors： Hilditch JR,Lewis J,Peter A,van Maris B,Ross A,Franssen E,Guyatt GH,Norton PG,Dunn E

更新日期：1996-07-01 00:00:00

abstract：:The recreational use of methamphetamine (METH, or ice) is a global burden. It pervades and plagues contemporary society; it has been estimated that there are up to 35 million users worldwide. METH is a highly addictive psychotropic compound which acts on the central nervous system, and chronic use can induce psychotic...

journal_title：Maturitas

authors： Papageorgiou M,Raza A,Fraser S,Nurgali K,Apostolopoulos V

更新日期：2019-03-01 00:00:00

abstract：:Worldwide, the number of menopausal women is increasing. They present with complex medical issues that lie beyond the traditional scope of gynaecologists and general practitioners (GPs). The European Menopause and Andropause Society (EMAS) therefore provides a holistic model of care for healthy menopause (HM). The HM ...

journal_title：Maturitas

authors： Stute P,Ceausu I,Depypere H,Lambrinoudaki I,Mueck A,Pérez-López FR,van der Schouw YT,Senturk LM,Simoncini T,Stevenson JC,Rees M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:To evaluate whether prolonged physical activity (25 km/week running for 8 years) modifies GH decline. DESIGN:The GH response to maximal exercise on bicycle-ergometer was tested in younger (26-30 years) and older (42-46 years) healthy women. Each age group included 2 subgroups of 10 sedentary and 10 runners, ...

journal_title：Maturitas

authors： Coiro V,Volpi R,Gramellini D,Maffei ML,Volta E,Melani A,Chiodera P

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To examine the association between the principal lifetime occupation and the incidence of Alzheimer's disease (AD) in men and women in a southern European population aged 55 years or more. STUDY DESIGN:A community-dwelling sample of 3883 dementia-free individuals aged 55 years or over was classified accordi...

journal_title：Maturitas

authors： Santabárbara J,Gracía-Rebled AC,López-Antón R,Tomás C,Lobo E,Marcos G,Lobo A

更新日期：2019-08-01 00:00:00

abstract：:The mean plasma anion gap (Na + K + Ca + Mg)--(Cl + HCO3(-) + HPO4(2-) + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/l). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in cit...

journal_title：Maturitas

authors： Hodgkinson A,Jones MM,Marshall RW,Skerrow SM

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:To determine the association between relationship distress and menopausal symptoms. STUDY DESIGN:A retrospective analysis was conducted of questionnaires completed by women 40-65 years of age seeking menopause or sexual health consultation between May, 2015 and May, 2017. MAIN OUTCOME MEASURES:Associations ...

journal_title：Maturitas

authors： Kling JM,Kelly M,Rullo J,Kapoor E,Kuhle CL,Vegunta S,Mara KC,Faubion SS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Aging and menopause are associated with an adverse cardiometabolic profile, predisposing to cardiovascular disease. Diet may also affect their cardiometabolic risk. The aim of this study is to assess dietary habits and patterns of postmenopausal women and their association with adiposity measures, cardiometab...

journal_title：Maturitas

authors： Stamatelopoulos K,Papavagelis C,Augoulea A,Armeni E,Karagkouni I,Avgeraki E,Georgiopoulos G,Yannakoulia M,Lambrinoudaki I

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to evaluate endothelium-dependent flow-mediated dilation (FMD) in the brachial artery and the plasma levels of endothelin-1 in postmenopausal women at risk for coronary artery disease before and after treatment with both estradiol and estradiol plus dydrogesterone. METHODS:Sixt...

journal_title：Maturitas

authors： Gambacciani M,Monteleone P,Vitale C,Silvestri A,Fini M,Genazzani AR,Rosano GM

更新日期：2002-10-25 00:00:00

abstract：OBJECTIVES:Despite their public health importance, little is known about associations between modifiable lifestyles, quality of life (QOL), and psychiatric symptoms in men. We investigated relationships between QOL, obesity, mobility and lifestyle in Australian men, including whether associations were mediated by anxie...

journal_title：Maturitas

authors： Brennan-Olsen SL,Pasco JA,Hosking SM,Dobbins AG,Williams LJ

更新日期：2017-09-01 00:00:00

abstract：:International, national and regional policy documents and key reports espouse the benefits of lifelong learning and people's rights to it, yet little attention has been given to the learning needs of frail older people in nursing (care) homes. People living in care have frequently been cited as a forgotten sector of t...

journal_title：Maturitas

authors： Kydd A,Fulford H

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The role of endogenous testosterone in the pathogenesis of type 2 diabetes mellitus remains vague. We investigated whether associations between endogenous testosterone and diabetes prevalence in men could be partially explained by modifiable risk factors. STUDY DESIGN:A random population-based cross-sectiona...

journal_title：Maturitas

authors： Atlantis E,Lange K,Martin S,Haren MT,Taylor A,O'Loughlin PD,Marshall V,Wittert GA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...

journal_title：Maturitas

authors： Albu A,Fodor D,Bondor C,Crăciun AM

更新日期：2013-10-01 00:00:00

abstract：:Age-related changes in the concentrations of the main plasma electrolytes and in the urinary excretion of some of these ions have been examined in 436 pre-menopausal and 117 post-menopausal women. The main changes up to the menopause were decreases in the mean plasma potassium, calcium and total protein concentrations...

journal_title：Maturitas

authors： Hodgkinson A

更新日期：1982-12-01 00:00:00

abstract：:Sera were sampled from 83 people (pre- and post-menopausal women and men). Climacteric symptoms of 23 women were treated with conjugated estrogen. Sera were sampled serially until the 21st day of estrogen administration. Serum concentrations of 40 protein components were measured by micro single radial immunodiffusion...

journal_title：Maturitas

authors： Hashimoto S,Miwa M,Akasofu K,Nishida E

更新日期：1991-03-01 00:00:00

abstract：:The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD...

journal_title：Maturitas

authors： Kuol N,Stojanovska L,Nurgali K,Apostolopoulos V

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Several studies drawn from the Ecuadorian population have previously reported that more than half of mid-aged women present hot flushes, which can impair their quality of life. However up-to-date risk factors for their presence and severity have not been assessed. OBJECTIVE:To assess hot flush frequency and...

journal_title：Maturitas

authors： Chedraui P,Aguirre W,Calle A,Hidalgo L,León-León P,Miranda O,Martínez N,Mendoza M,Narváez J,Sánchez H,Schwager G,Quintero JC,Zambrano B,Aguilar A,Martínez MA,Rivera R,Ruilova I

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:The effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with non-insulin dependent diabetes mellitus (type II diabetes) is uncertain. METHODS:The effects of estrogen replacement therapy (ERT, conjugated equine estrogen0.625mg orally daily), combined estrogen and con...

journal_title：Maturitas

authors： Manwaring P,Morfis L,Diamond T,Howes LG

更新日期：2000-03-31 00:00:00

abstract：OBJECTIVES:To characterise changes in nationwide fall-related mortality rates in Australia and the United Kingdom (UK) between 2006 and 2016 by age group and sex. STUDY DESIGN:Trend analysis of falls mortality data from World Health Organization (WHO) Mortality Database for the Australian and UK population. MAIN OUTC...

journal_title：Maturitas

authors： Wu H,Mach J,Le Couteur DG,Hilmer SN

更新日期：2020-12-01 00:00:00

abstract：:Cardiovascular disease is the leading determinant of mortality and morbidity in women. Functional foods are attracting interest as potential regulators of the susceptibility to disease. Supported by epidemiological evidence, chocolate has emerged as a possible modulator of cardiovascular risk. Chocolate, or cocoa as t...

journal_title：Maturitas

authors： Fernández-Murga L,Tarín JJ,García-Perez MA,Cano A

更新日期：2011-08-01 00:00:00

abstract：:Combination therapy strategies for osteoporosis are reviewed in this article. Regimens including two antiresorptives agents increase BMD more than single therapy alone, but they have not proved to reduce fracture risk. The alternative of combining antiresorptives together with anabolics has gained more interest. There...

journal_title：Maturitas

authors： Garcés C,García LE

更新日期：2006-04-20 00:00:00

abstract：:Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...

journal_title：Maturitas

authors： Zoet GA,Koster MP,Velthuis BK,de Groot CJ,Maas AH,Fauser BC,Franx A,van Rijn BB

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...

journal_title：Maturitas

authors： Danckers L,Blümel JE,Witis S,Vallejo MS,Tserotas K,Sánchez H,Salinas C,Saavedra J,Rojas JA,Onatra W,Ojeda E,Mostajo D,Morera F,Monterrosa A,Montaño A,Meruvia N,Martino M,Martínez J,Lima S,González E,Gómez G,Espi

更新日期：2016-05-01 00:00:00

abstract：:A prospective study was conducted amongst Hong Kong Chinese women to determine the incidence of acute menopausal symptoms following surgical menopause. Cases where a laparotomy was performed for other indications were used as controls. Hot flushes and sweating developed in 8/33 (24.2%) and 6/33 (18.2%), respectively, ...

journal_title：Maturitas

authors： Haines CJ,Chung TK,Leung DH

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...

journal_title：Maturitas

authors： Karjalainen AH,Ruskoaho H,Vuolteenaho O,Heikkinen JE,Bäckström AC,Savolainen MJ,Kesäniemi YA

更新日期：2004-03-15 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...

journal_title：Maturitas

authors： O'Toole SA,Dunn E,Sheppard BL,Sheils O,O'Leary JJ,Wuttke W,Seidlova-Wuttke D

更新日期：2005-06-16 00:00:00

abstract：:Heart disease is a major cause of death, disease and disability in the developed world for both men and women. Women appear to be under-diagnosed and treated both because they fail to visit the doctor or hospital with relevant symptoms and because doctors tend to dismiss the seriousness of women's symptoms of heart di...

journal_title：Maturitas

authors： Clarke J

更新日期：2010-03-01 00:00:00