Abstract:
:Vitamin D, a soluble steroid hormone synthesized in the skin after sun exposure, plays a crucial role in calcium metabolism and is also involved in cardiovascular pathophysiology. The aim of this review is to summarize the available evidence (a) on the association between endogenous vitamin D status and cardiovascular disease, and (b) on the effect of vitamin D supplementation on cardiovascular outcomes. Most studies have shown an inverse association between vitamin D levels and cardiovascular outcomes. Randomized controlled trials, however, do not consistently support a beneficial effect of vitamin D administration on cardiovascular health. Population characteristics, comorbid conditions such as diabetes, the overall population prevalence of cardiovascular disease, vitamin D status and the regimen of vitamin D supplementation may account for the conflicting results.
journal_name
Maturitasjournal_title
Maturitasauthors
Apostolakis M,Armeni E,Bakas P,Lambrinoudaki Idoi
10.1016/j.maturitas.2018.05.010subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1-22eissn
0378-5122issn
1873-4111pii
S0378-5122(18)30217-2journal_volume
115pub_type
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