A reconfigurable arbitrary waveform generator using PWM modulation for ultrasound research.

Abstract:

BACKGROUND:In ultrasound imaging systems, the digital transmit beamformer is a critical module that generates accurate control over several transmission parameters. However, such transmit front-end module is not typically accessible to ultrasound researchers. To overcome this difficulty, we have been developing a compact and fully programmable digital transmit system using the pulse-width modulation (PWM) technique for generating simultaneous arbitrary waveforms, specifically designed for research purposes. METHODS:In this paper we present a reconfigurable arbitrary waveform generator (RAWG) for ultrasound research applications that exploits a high frequency PWM scheme implemented in a low-cost FPGA, taking advantage of its flexibility and parallel processing capability for independent controlling of multiple transmission parameters. The 8-channel platform consists of a FPGA-based development board including an USB 2.0 interface and an arbitrary waveform generator board with eight MD2130 beamformer source drivers for individual control of waveform, amplitude apodization, phase angle and time delay trigger. RESULTS:To evaluate the efficiency of our system, we used equivalent RC loads (1 kΩ and 220 pF) to produce arbitrary excitation waveforms with the Gaussian and Tukey profiles. The PWM carrier frequency was set at 160 MHz featuring high resolution while keeping a minimum time delay of 3.125 ns between pulses to enable the acoustic beam to be focused and/or steered electronically. Preliminary experimental results show that the RAWG can produce complex arbitrary pulses with amplitude over 100 Vpp and central frequency up to 20 MHz with satisfactory linearity of the amplitude apodization, as well as focusing phase adjustment capability with angular resolution of 7.5°. CONCLUSIONS:The initial results of this study showed that the proposed research system is suitable for generating simultaneous arbitrary waveforms, providing extensive user control with direct digital access to the various transmission parameters needed to explore alternative ultrasound transmission techniques.

journal_name

Biomed Eng Online

authors

Assef AA,Maia JM,Schneider FK,Button VL,Costa ET

doi

10.1186/1475-925X-12-24

subject

Has Abstract

pub_date

2013-03-20 00:00:00

pages

24

issn

1475-925X

pii

1475-925X-12-24

journal_volume

12

pub_type

杂志文章
  • Low-cost equipment for the evaluation of reach and grasp in post-stroke individuals: a pilot study.

    abstract:BACKGROUND:Reach-grasp movements are motor components commonly affected after stroke and directly related to the independence of these individuals. Evaluations of these activities can be performed using clinical instruments and assessed by detailed and costly kinematic analyses. The aim of this study was to develop an ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-020-0758-7

    authors: Gomes CLA,Cacho RO,Nobrega VTB,de A Confessor EM,de Farias EEM,Neto JLF,de Araújo DS,de S Medeiros AL,Barreto RL,Cacho EWA

    更新日期:2020-03-04 00:00:00

  • Why brain-controlled neuroprosthetics matter: mechanisms underlying electrical stimulation of muscles and nerves in rehabilitation.

    abstract::Delivering short trains of electric pulses to the muscles and nerves can elicit action potentials resulting in muscle contractions. When the stimulations are sequenced to generate functional movements, such as grasping or walking, the application is referred to as functional electrical stimulation (FES). Implications ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章,评审

    doi:10.1186/s12938-020-00824-w

    authors: Milosevic M,Marquez-Chin C,Masani K,Hirata M,Nomura T,Popovic MR,Nakazawa K

    更新日期:2020-11-04 00:00:00

  • Colonoscopy procedure simulation: virtual reality training based on a real time computational approach.

    abstract:BACKGROUND:Colonoscopy plays an important role in the clinical screening and management of colorectal cancer. The traditional 'see one, do one, teach one' training style for such invasive procedure is resource intensive and ineffective. Given that colonoscopy is difficult, and time-consuming to master, the use of virtu...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0433-4

    authors: Wen T,Medveczky D,Wu J,Wu J

    更新日期:2018-01-25 00:00:00

  • Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging.

    abstract:BACKGROUND:Tumor hypoxia is involved in every stage of solid tumor development: formation, progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors-chronic hypoxia and acute hypoxia. Recent studies indicate that the regional hypoxia kinetics is closely linked to metastasis and therapeutic responses,...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0235-5

    authors: Lee CW,Stantz KM

    更新日期:2016-10-12 00:00:00

  • Effects of 8-week swimming training on carotid arterial stiffness and hemodynamics in young overweight adults.

    abstract:BACKGROUND:Exercise has been found to either reduce or increase arterial stiffness. Land-based exercise modalities have been documented as effective physical therapies to decrease arterial stiffness. However, these land-based exercise modalities may not be suitable for overweight individuals, in terms of risks of joint...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0274-y

    authors: Yuan WX,Liu HB,Gao FS,Wang YX,Qin KR

    更新日期:2016-12-28 00:00:00

  • Examination of ceramic restoration adhesive coverage in cusp-replacement premolar using acoustic emission under fatigue testing.

    abstract:BACKGROUND:This study investigates CAD/CAM ceramic cusp-replacing restoration resistance with and without buccal cusp replacement under static and dynamic cyclic loads, monitored using the acoustic emission (AE) technique. METHOD:The cavity was designed in a typical MODP (mesial-occlusal-distal-palatal) restoration fa...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-13-165

    authors: Chang YH,Yu JJ,Lin CL

    更新日期:2014-12-13 00:00:00

  • Image based evaluation of mediastinal constraints for the development of a pulsatile total artificial heart.

    abstract:BACKGROUND:Good anatomical compatibility is an important aspect in the development of cardiovascular implants. This work analyzes the interaction of the pump unit of an electrically driven pulsatile Total Artificial Heart (TAH) and the mediastinum. For an adequate compliance, both overall dimensions and alignment of in...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-81

    authors: Fritschi AJ,Laumen M,Spiliopoulos S,Finocchiaro T,Egger C,Schmitz-Rode T,Tenderich G,Koerfer R,Steinseifer U

    更新日期:2013-08-14 00:00:00

  • Hemodynamic effects of perfusion level of peripheral ECMO on cardiovascular system.

    abstract:BACKGROUND:Peripheral ECMO is an effective cardiopulmonary support in clinical. The perfusion level could directly influence the performances and complications. However, there are few studies on the effects of the perfusion level on hemodynamics of peripheral ECMO. METHODS:The geometric model of cardiovascular system ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0493-5

    authors: Gu K,Zhang Z,Gao B,Chang Y,Wan F

    更新日期:2018-05-09 00:00:00

  • Voluntary EMG-to-force estimation with a multi-scale physiological muscle model.

    abstract:BACKGROUND:EMG-to-force estimation based on muscle models, for voluntary contraction has many applications in human motion analysis. The so-called Hill model is recognized as a standard model for this practical use. However, it is a phenomenological model whereby muscle activation, force-length and force-velocity prope...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-86

    authors: Hayashibe M,Guiraud D

    更新日期:2013-09-04 00:00:00

  • Unsupervised machine-learning method for improving the performance of ambulatory fall-detection systems.

    abstract:BACKGROUND:Falls can cause trauma, disability and death among older people. Ambulatory accelerometer devices are currently capable of detecting falls in a controlled environment. However, research suggests that most current approaches can tend to have insufficient sensitivity and specificity in non-laboratory environme...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-11-9

    authors: Yuwono M,Moulton BD,Su SW,Celler BG,Nguyen HT

    更新日期:2012-02-16 00:00:00

  • Designing and testing scene enhancement algorithms for patients with retina degenerative disorders.

    abstract:BACKGROUND:Retina degenerative disorders represent the primary cause of blindness in UK and in the developed world. In particular, Age Related Macular Degeneration (AMD) and Retina Pigmentosa (RP) diseases are of interest to this study. We have therefore created new image processing algorithms for enhancing the visual ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-9-27

    authors: Al-Atabany WI,Memon MA,Downes SM,Degenaar PA

    更新日期:2010-06-18 00:00:00

  • Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI.

    abstract:BACKGROUND:Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid dynamics (CFD) calculations...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-015-0104-7

    authors: Rispoli VC,Nielsen JF,Nayak KS,Carvalho JL

    更新日期:2015-11-26 00:00:00

  • Effect of amplitude and duration of impulsive pressure on endothelial permeability in in vitro fluid percussion trauma.

    abstract:BACKGROUND:Intracranial pressure changes during head impact cause brain injuries such as vasogenic edema and cerebral contusion. However, the influence of impulsive pressure on endothelial function has not yet been fully studied in vitro. In this study, we developed a pressure loading device that produced positive and ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-13-44

    authors: Nakadate H,Inuzuka K,Akanuma S,Kakuta A,Aomura S

    更新日期:2014-04-16 00:00:00

  • Identification of dental root canals and their medial line from micro-CT and cone-beam CT records.

    abstract:BACKGROUND:Shape of the dental root canal is highly patient specific. Automated identification methods of the medial line of dental root canals and the reproduction of their 3D shape can be beneficial for planning endodontic interventions as severely curved root canals or multi-rooted teeth may pose treatment challenge...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-11-81

    authors: Benyó B

    更新日期:2012-10-29 00:00:00

  • Public access defibrillation: suppression of 16.7 Hz interference generated by the power supply of the railway systems.

    abstract:BACKGROUND:A specific problem using the public access defibrillators (PADs) arises at the railway stations. Some countries as Germany, Austria, Switzerland, Norway and Sweden are using AC railroad net power-supply system with rated 16.7 Hz frequency modulated from 15.69 Hz to 17.36 Hz. The power supply frequency contam...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-4-16

    authors: Christov II,Iliev GL

    更新日期:2005-03-15 00:00:00

  • Automatic diagnosis of imbalanced ophthalmic images using a cost-sensitive deep convolutional neural network.

    abstract:BACKGROUND:Ocular images play an essential role in ophthalmological diagnoses. Having an imbalanced dataset is an inevitable issue in automated ocular diseases diagnosis; the scarcity of positive samples always tends to result in the misdiagnosis of severe patients during the classification task. Exploring an effective...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-017-0420-1

    authors: Jiang J,Liu X,Zhang K,Long E,Wang L,Li W,Liu L,Wang S,Zhu M,Cui J,Liu Z,Lin Z,Li X,Chen J,Cao Q,Li J,Wu X,Wang D,Wang J,Lin H

    更新日期:2017-11-21 00:00:00

  • Biomechanical simulation of thorax deformation using finite element approach.

    abstract:BACKGROUND:The biomechanical simulation of the human respiratory system is expected to be a useful tool for the diagnosis and treatment of respiratory diseases. Because the deformation of the thorax significantly influences airflow in the lungs, we focused on simulating the thorax deformation by introducing contraction...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0132-y

    authors: Zhang G,Chen X,Ohgi J,Miura T,Nakamoto A,Matsumura C,Sugiura S,Hisada T

    更新日期:2016-02-06 00:00:00

  • Reviewing the connection between speech and obstructive sleep apnea.

    abstract:BACKGROUND:Sleep apnea (OSA) is a common sleep disorder characterized by recurring breathing pauses during sleep caused by a blockage of the upper airway (UA). The altered UA structure or function in OSA speakers has led to hypothesize the automatic analysis of speech for OSA assessment. In this paper we critically rev...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0138-5

    authors: Espinoza-Cuadros F,Fernández-Pozo R,Toledano DT,Alcázar-Ramírez JD,López-Gonzalo E,Hernández-Gómez LA

    更新日期:2016-02-20 00:00:00

  • Prospects of implant with locking plate in fixation of subtrochanteric fracture: experimental demonstration of its potential benefits on synthetic femur model with supportive hierarchical nonlinear hyperelastic finite element analysis.

    abstract:BACKGROUND:Effective fixation of fracture requires careful selection of a suitable implant to provide stability and durability. Implant with a feature of locking plate (LP) has been used widely for treating distal fractures in femur because of its favourable clinical outcome, but its potential in fixing proximal fractu...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-11-23

    authors: Latifi MH,Ganthel K,Rukmanikanthan S,Mansor A,Kamarul T,Bilgen M

    更新日期:2012-04-30 00:00:00

  • Integrated EIT system for functional lung ventilation imaging.

    abstract:BACKGROUND:Electrical impedance tomography (EIT) has been used for functional lung imaging of regional air distributions during mechanical ventilation in intensive care units (ICU). From numerous clinical and animal studies focusing on specific lung functions, a consensus about how to use the EIT technique has been for...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-019-0701-y

    authors: Jang GY,Ayoub G,Kim YE,Oh TI,Chung CR,Suh GY,Woo EJ

    更新日期:2019-07-25 00:00:00

  • Novel dynamic corneal response parameters in a practice use: a critical review.

    abstract:BACKGROUND:Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章,评审

    doi:10.1186/s12938-019-0636-3

    authors: Jędzierowska M,Koprowski R

    更新日期:2019-02-13 00:00:00

  • Characterization of the head-to-trunk orientation with handheld optical 3D apparatus based on the fringe projection technique.

    abstract:BACKGROUND:Knowing the orientation of the head is important in many fields, including medicine. Many methods and measuring systems exist, but usually they use different markers or sensors attached to the subject's head for head orientation determination. In certain applications these attachments may represent a burden ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-96

    authors: Pavlovčič U,Diaci J,Možina J,Jezeršek M

    更新日期:2013-09-26 00:00:00

  • Patterned thin metal film for the lateral resolution measurement of photoacoustic tomography.

    abstract:BACKGROUND:Image quality assessment method of photoacoustic tomography has not been completely standardized yet. Due to the combined nature of photonic signal generation and ultrasonic signal transmission in biological tissue, neither optical nor ultrasonic traditional methods can be used without modification. An optic...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-11-37

    authors: Kim DH,Shin DH,Ryu SH,Song CG

    更新日期:2012-07-13 00:00:00

  • Open source model for generating RR intervals in atrial fibrillation and beyond.

    abstract:BACKGROUND:Realistic modeling of cardiac inter-beat (RR) intervals is highly desirable for basic research in cardiac electrophysiology, clinical management of heart diseases, and developing signal processing tools for ECG analysis. METHODS:We present an open source computer model that is capable to generate realistic ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-6-9

    authors: Lian J,Clifford GD,Müssig D,Lang V

    更新日期:2007-03-02 00:00:00

  • Developing functional workspace for the movement of trunk circumduction in healthy young subjects: a reliability study.

    abstract:BACKGROUND:The lumbar range of motion has traditionally been used to assess disability in patients with low back disorders. Controversy exists about how movement ranges in static positions or in a single straight plane is related to the functional status of the patients. The trunk circumduction, as the result of neurom...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-4

    authors: Cheng SC,Hsu CH,Ting YT,Kuo LC,Lin RM,Su FC

    更新日期:2013-01-11 00:00:00

  • A reference dataset for verifying numerical electrophysiological heart models.

    abstract:BACKGROUND:The evaluation, verification and comparison of different numerical heart models are difficult without a commonly available database that could be utilized as a reference. Our aim was to compile an exemplary dataset. METHODS:The following methods were employed: Magnetic Resonance Imaging (MRI) of heart and t...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-10-11

    authors: Koch H,Bousseljot RD,Kosch O,Jahnke C,Paetsch I,Fleck E,Schnackenburg B

    更新日期:2011-01-27 00:00:00

  • Probability mapping of scarred myocardium using texture and intensity features in CMR images.

    abstract:BACKGROUND:The myocardium exhibits heterogeneous nature due to scarring after Myocardial Infarction (MI). In Cardiac Magnetic Resonance (CMR) imaging, Late Gadolinium (LG) contrast agent enhances the intensity of scarred area in the myocardium. METHODS:In this paper, we propose a probability mapping technique using Te...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-91

    authors: Kotu LP,Engan K,Skretting K,Måløy F,Orn S,Woie L,Eftestøl T

    更新日期:2013-09-22 00:00:00

  • Influence of vascular geometry on local hemodynamic parameters: phantom and small rodent study.

    abstract:BACKGROUND:Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wall circumferential strain and its instantaneous wall shear stress is known as stress phase angle (SPA...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0458-8

    authors: Niu L,Zhu X,Pan M,Derek A,Xu L,Meng L,Zheng H

    更新日期:2018-03-02 00:00:00

  • Wound healing of human embryonic stem cell-derived retinal pigment epithelial cells is affected by maturation stage.

    abstract:BACKGROUND:Wound healing of retinal pigment epithelium (RPE) is a complex process that may take place in common age-related macular degeneration eye disease. The purpose of this study was to evaluate whether wounding and wound healing has an effect on Ca2+ dynamics in human embryonic stem cell (hESC)-RPEs cultured diff...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0535-z

    authors: Abu Khamidakh AE,Rodriguez-Martinez A,Kaarniranta K,Kallioniemi A,Skottman H,Hyttinen J,Juuti-Uusitalo K

    更新日期:2018-07-31 00:00:00

  • Novel flexible cap for application of transcranial electrical stimulation: a usability study.

    abstract:BACKGROUND:Advances in transcranial electrical stimulation (tES) are hampered by the conventional rubber electrodes manually attached to the head with rubber bands. This procedure limits montages to a few electrodes, is error prone with respect to electrode configurations and is burdensome for participants and operator...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-020-00792-1

    authors: Hunold A,Ortega D,Schellhorn K,Haueisen J

    更新日期:2020-06-17 00:00:00