Open source model for generating RR intervals in atrial fibrillation and beyond.

Abstract:

BACKGROUND:Realistic modeling of cardiac inter-beat (RR) intervals is highly desirable for basic research in cardiac electrophysiology, clinical management of heart diseases, and developing signal processing tools for ECG analysis. METHODS:We present an open source computer model that is capable to generate realistic time series of RR intervals in both physiologic and pathologic conditions. Detailed model structure and the software implementation are described. RESULTS:Examples are provided on how to use this model to generate RR intervals in atrial fibrillation with ventricular pacing, normal sinus rhythm with heart rate variability, and typical atrial flutter with atrioventricular block. The extensibility of the model is also discussed. CONCLUSION:The present computer model provides a unified platform wherein various types of ventricular rhythm can be simulated. The availability of this open source model promises to support and stimulate future studies.

journal_name

Biomed Eng Online

authors

Lian J,Clifford GD,Müssig D,Lang V

doi

10.1186/1475-925X-6-9

subject

Has Abstract

pub_date

2007-03-02 00:00:00

pages

9

issn

1475-925X

pii

1475-925X-6-9

journal_volume

6

pub_type

杂志文章
  • Artery buckling affects the mechanical stress in atherosclerotic plaques.

    abstract:BACKGROUND:Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-14-S1-S4

    authors: Sanyal A,Han HC

    更新日期:2015-01-01 00:00:00

  • Evolutionary optimization of classifiers and features for single-trial EEG discrimination.

    abstract:BACKGROUND:State-of-the-art signal processing methods are known to detect information in single-trial event-related EEG data, a crucial aspect in development of real-time applications such as brain computer interfaces. This paper investigates one such novel approach, evaluating how individual classifier and feature sub...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-6-32

    authors: Aberg MC,Wessberg J

    更新日期:2007-08-23 00:00:00

  • Biomechanical simulation of thorax deformation using finite element approach.

    abstract:BACKGROUND:The biomechanical simulation of the human respiratory system is expected to be a useful tool for the diagnosis and treatment of respiratory diseases. Because the deformation of the thorax significantly influences airflow in the lungs, we focused on simulating the thorax deformation by introducing contraction...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0132-y

    authors: Zhang G,Chen X,Ohgi J,Miura T,Nakamoto A,Matsumura C,Sugiura S,Hisada T

    更新日期:2016-02-06 00:00:00

  • Motor recovery monitoring using acceleration measurements in post acute stroke patients.

    abstract:BACKGROUND:Stroke is one of the major causes of morbidity and mortality. Its recovery and treatment depends on close clinical monitoring by a clinician especially during the first few hours after the onset of stroke. Patients who do not exhibit early motor recovery post thrombolysis may benefit from more aggressive tre...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-33

    authors: Gubbi J,Rao AS,Fang K,Yan B,Palaniswami M

    更新日期:2013-04-16 00:00:00

  • Phantom-based experimental validation of fast virtual deployment of self-expandable stents for cerebral aneurysms.

    abstract:BACKGROUND:Endovascular intervention using a stent is a mainstream treatment for cerebral aneurysms. To assess the effect of intervention strategies on aneurysm hemodynamics, we have developed a fast virtual stenting (FVS) technique to simulate stent deployment in patient-specific aneurysms. However, quantitative valid...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0250-6

    authors: Zhang Q,Meng Z,Zhang Y,Yao K,Liu J,Zhang Y,Jing L,Yang X,Paliwal N,Meng H,Wang S

    更新日期:2016-12-28 00:00:00

  • Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI.

    abstract:BACKGROUND:Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid dynamics (CFD) calculations...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-015-0104-7

    authors: Rispoli VC,Nielsen JF,Nayak KS,Carvalho JL

    更新日期:2015-11-26 00:00:00

  • Challenges, issues and trends in fall detection systems.

    abstract::Since falls are a major public health problem among older people, the number of systems aimed at detecting them has increased dramatically over recent years. This work presents an extensive literature review of fall detection systems, including comparisons among various kinds of studies. It aims to serve as a referenc...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章,评审

    doi:10.1186/1475-925X-12-66

    authors: Igual R,Medrano C,Plaza I

    更新日期:2013-07-06 00:00:00

  • Heart rate variability analysis using robust period detection.

    abstract:OBJECTIVE:Heart rate variability (HRV) analysis, which is an important tool for activity assessment of the cardiac autonomic nervous system, very often includes the estimation of power spectra for series of interbeat intervals (IBI). Ectopic beats and artifacts have a destructive effect on the standard methods (Fourier...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-13-138

    authors: Skotte JH,Kristiansen J

    更新日期:2014-09-23 00:00:00

  • Review of cognitive behavioural therapy mobile apps using a reference architecture embedded in the patient-provider relationship.

    abstract:BACKGROUND:Mobile health apps (mHealth apps) are increasing in popularity and utility for the management of many chronic diseases. Although the current reimbursement structure for mHealth apps is lagging behind the rapidly improving functionality, more clinicians will begin to recommend these apps as they prove their c...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0611-4

    authors: Lan A,Lee A,Munroe K,McRae C,Kaleis L,Keshavjee K,Guergachi A

    更新日期:2018-12-17 00:00:00

  • Using stochastic modelling to identify unusual continuous glucose monitor measurements and behaviour, in newborn infants.

    abstract:BACKGROUND:Abnormal blood glucose (BG) concentrations have been associated with increased morbidity and mortality in both critically ill adults and infants. Furthermore, hypoglycaemia and glycaemic variability have both been independently linked to mortality in these patients. Continuous Glucose Monitoring (CGM) device...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-11-45

    authors: Signal M,Le Compte A,Harris DL,Weston PJ,Harding JE,Chase JG,CHYLD Study Group.

    更新日期:2012-08-06 00:00:00

  • Development and mechanical testing of a short intramedullary nail for fixation of femoral rotational osteotomy in cerebral palsy patients.

    abstract:BACKGROUND:Rotational osteotomy is frequently indicated to correct excessive femoral anteversion in cerebral palsy patients. Angled blade plate is the standard fixation device used when performed in the proximal femur, but extensile exposure is required for plate accommodation. The authors developed a short locked intr...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-10-57

    authors: Pagnano RG,Okubo R,Volpon JB

    更新日期:2011-06-28 00:00:00

  • The influence of probe level on the tuning of stimulus frequency otoacoustic emissions and behavioral test in human.

    abstract:BACKGROUND:Frequency selectivity (FS) of the auditory system is established at the level of the cochlea and it is important for the perception of complex sounds. Although direct measurements of cochlear FS require surgical preparation, it can also be estimated with the measurements of otoacoustic emissions or behaviora...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-016-0167-0

    authors: Wang Y,Gong Q,Zhang T

    更新日期:2016-05-10 00:00:00

  • Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis.

    abstract:BACKGROUND:In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric oxide synthase (eNOS) encoding plasmid DNA administered using coated stents in a rabbit iliac artery restenosis model. METHODS:Lipopolyplexes (LPPs) with eNOS expressing plasmid DNA we...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-9-56

    authors: Brito LA,Chandrasekhar S,Little SR,Amiji MM

    更新日期:2010-09-27 00:00:00

  • A reconfigurable arbitrary waveform generator using PWM modulation for ultrasound research.

    abstract:BACKGROUND:In ultrasound imaging systems, the digital transmit beamformer is a critical module that generates accurate control over several transmission parameters. However, such transmit front-end module is not typically accessible to ultrasound researchers. To overcome this difficulty, we have been developing a compa...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-24

    authors: Assef AA,Maia JM,Schneider FK,Button VL,Costa ET

    更新日期:2013-03-20 00:00:00

  • Performance evaluation of a motor-imagery-based EEG-Brain computer interface using a combined cue with heterogeneous training data in BCI-Naive subjects.

    abstract:BACKGROUND:The subjects in EEG-Brain computer interface (BCI) system experience difficulties when attempting to obtain the consistent performance of the actual movement by motor imagery alone. It is necessary to find the optimal conditions and stimuli combinations that affect the performance factors of the EEG-BCI syst...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-10-91

    authors: Choi D,Ryu Y,Lee Y,Lee M

    更新日期:2011-10-12 00:00:00

  • Estimation of pelvis kinematics in level walking based on a single inertial sensor positioned close to the sacrum: validation on healthy subjects with stereophotogrammetric system.

    abstract:BACKGROUND:Kinematics measures from inertial sensors have a value in the clinical assessment of pathological gait, to track quantitatively the outcome of interventions and rehabilitation programs. To become a standard tool for clinicians, it is necessary to evaluate their capability to provide reliable and comprehensib...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-13-146

    authors: Buganè F,Benedetti MG,D'Angeli V,Leardini A

    更新日期:2014-10-21 00:00:00

  • The development and application of an oncology Therapy-Related Symptom Checklist for Adults (TRSC) and Children (TRSC-C) and e-health applications.

    abstract:BACKGROUND:Studies found that treatment symptoms of concern to oncology/hematology patients were greatly under-identified in medical records. On average, 11.0 symptoms were reported of concern to patients compared to 1.5 symptoms identified in their medical records. A solution to this problem is use of an electronic sy...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-14-S2-S1

    authors: Williams AR,Williams DD,Williams PD,Alemi F,Hesham H,Donley B,Kheirbek RE

    更新日期:2015-01-01 00:00:00

  • Exploiting nonlinear recurrence and fractal scaling properties for voice disorder detection.

    abstract:BACKGROUND:Voice disorders affect patients profoundly, and acoustic tools can potentially measure voice function objectively. Disordered sustained vowels exhibit wide-ranging phenomena, from nearly periodic to highly complex, aperiodic vibrations, and increased "breathiness". Modelling and surrogate data studies have s...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-6-23

    authors: Little MA,McSharry PE,Roberts SJ,Costello DA,Moroz IM

    更新日期:2007-06-26 00:00:00

  • An inverse method to determine the mechanical properties of the iris in vivo.

    abstract:BACKGROUND:Understanding the mechanical properties of the iris can help to have an insight into the eye diseases with abnormalities of the iris morphology. Material parameters of the iris were simply calculated relying on the ex vivo experiment. However, the mechanical response of the iris in vivo is different from tha...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-13-66

    authors: Zhang K,Qian X,Mei X,Liu Z

    更新日期:2014-05-30 00:00:00

  • A multivariate relationship between the kinematic and clinical parameters of knee osteoarthritis population.

    abstract:BACKGROUND:Biomechanical and clinical parameters contribute very closely to functional evaluations of the knee joint. To better understand knee osteoarthritis joint function, the association between a set of knee biomechanical data and a set of clinical parameters of an osteoarthritis population (OA) is investigated in...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-019-0676-8

    authors: Bensalma F,Mezghani N,Ouakrim Y,Fuentes A,Choinière M,Bureau NJ,Durand M,Hagemeister N

    更新日期:2019-05-15 00:00:00

  • Effect of glutaraldehyde based cross-linking on the viscoelasticity of mitral valve basal chordae tendineae.

    abstract:BACKGROUND:Mitral valve failure can require repair or replacement. Replacement bioprosthetic valves are treated with glutaraldehyde prior to implantation. The aim of this study was to determine the changes in mechanical properties following glutaraldehyde fixation of mitral valve chordae. METHODS:To investigate the im...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-018-0524-2

    authors: Constable M,Burton HE,Lawless BM,Gramigna V,Buchan KG,Espino DM

    更新日期:2018-07-13 00:00:00

  • Feature extraction for the analysis of colon status from the endoscopic images.

    abstract:BACKGROUND:Extracting features from the colonoscopic images is essential for getting the features, which characterizes the properties of the colon. The features are employed in the computer-assisted diagnosis of colonoscopic images to assist the physician in detecting the colon status. METHODS:Endoscopic images contai...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925x-2-9

    authors: Tjoa MP,Krishnan SM

    更新日期:2003-04-08 00:00:00

  • Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes.

    abstract:BACKGROUND:We sought to compare uterine cervical electrical impedance spectroscopy measurements employing two probes of different sizes, and to employ a finite element model to predict and compare the fraction of electrical current derived from subepithelial stromal tissue. METHODS:Cervical impedance was measured in 1...

    journal_title:Biomedical engineering online

    pub_type: 临床试验,杂志文章

    doi:10.1186/1475-925X-5-62

    authors: Gandhi SV,Walker DC,Brown BH,Anumba DO

    更新日期:2006-11-24 00:00:00

  • Infrared thermography fails to visualize stimulation-induced meridian-like structures: comment by Rixin Chen and Zhimai Lv and reply from Gerhard Litscher.

    abstract::A comment on G. Litscher: Infrared thermography fails to visualize stimulation-induced meridian-like structures. Biomed. Eng. OnLine 2005, 4:38 (15 June 2005), with a response by the author. ...

    journal_title:Biomedical engineering online

    pub_type: 评论,信件

    doi:10.1186/1475-925X-10-80

    authors: Chen R,Lv Z

    更新日期:2011-09-11 00:00:00

  • 3-Dimensional printing in rehabilitation: feasibility of printing an upper extremity gross motor function assessment tool.

    abstract:BACKGROUND:Use of standardized and scientifically sound outcome measures is encouraged in clinical practice and research. With the development of newer rehabilitation therapies, we need technology-supported upper extremity outcome measures that are easily accessible, reliable and valid. 3-Dimensional printing (3D-print...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-020-00839-3

    authors: Kapadia N,Myers M,Musselman K,Wang RH,Yurkewich A,Popovic MR

    更新日期:2021-01-05 00:00:00

  • Correction to: Effects of astrocyte on neuronal outgrowth in a layered 3D structure.

    abstract::It was highlighted that the original article [1] contained an error in the Acknowledgments section. ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12938-019-0707-5

    authors: Fang A,Li D,Hao Z,Wang L,Pan B,Gao L,Qu X,He J

    更新日期:2019-08-08 00:00:00

  • Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism.

    abstract:BACKGROUND:A computational model of myocardial energy metabolism was used to assess the metabolic responses to normal and reduced myocardial blood flow. The goal was to examine to what extent glycolysis and lactate formation are controlled by the supply of glycolytic substrate and/or the cellular redox (NADH/NAD+) and ...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-3-15

    authors: Salem JE,Stanley WC,Cabrera ME

    更新日期:2004-06-02 00:00:00

  • 3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation.

    abstract:BACKGROUND:The challenges of glycaemic control in critically ill patients have been debated for 20 years. While glycaemic control shows benefits inter- and intra-patient metabolic variability results in increased hypoglycaemia and glycaemic variability, both increasing morbidity and mortality. Hence, current recommenda...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-019-0720-8

    authors: Uyttendaele V,Knopp JL,Davidson S,Desaive T,Benyo B,Shaw GM,Chase JG

    更新日期:2019-10-22 00:00:00

  • Developing functional workspace for the movement of trunk circumduction in healthy young subjects: a reliability study.

    abstract:BACKGROUND:The lumbar range of motion has traditionally been used to assess disability in patients with low back disorders. Controversy exists about how movement ranges in static positions or in a single straight plane is related to the functional status of the patients. The trunk circumduction, as the result of neurom...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/1475-925X-12-4

    authors: Cheng SC,Hsu CH,Ting YT,Kuo LC,Lin RM,Su FC

    更新日期:2013-01-11 00:00:00

  • PDE based scheme for multi-modal medical image watermarking.

    abstract:BACKGROUND:This work deals with copyright protection of digital images, an issue that needs protection of intellectual property rights. It is an important issue with a large number of medical images interchanged on the Internet every day. So, it is a challenging task to ensure the integrity of received images as well a...

    journal_title:Biomedical engineering online

    pub_type: 杂志文章

    doi:10.1186/s12938-015-0101-x

    authors: Aherrahrou N,Tairi H

    更新日期:2015-11-25 00:00:00