Abstract：
BACKGROUND:Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque. METHODS:Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature. RESULTS:Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque. CONCLUSIONS:Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Sanyal A,Han HCdoi
10.1186/1475-925X-14-S1-S4subject
Has Abstractpub_date
2015-01-01 00:00:00pages
S4issn
1475-925Xpii
1475-925X-14-S1-S4journal_volume
14 Suppl 1pub_type
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