Abstract：
BACKGROUND:The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent signals recorded from the nerves and associated to hand movements. FINDINGS:To address this issue, in this work we acquired neural efferent activities from healthy subjects performing hand-related tasks using ultrasound-guided microneurography, a minimally invasive technique, which employs needles, inserted percutaneously, to record from nerve fibers. These signals allowed us to identify neural features correlated with force and velocity of finger movements that were used to decode motor intentions. We developed computational models, which confirmed the potential translatability of these results showing how these neural features hold in absence of feedback and when implantable intrafascicular recording, rather than microneurography, is performed. CONCLUSIONS:Our results are a proof of principle that microneurography could be used as a useful tool to assist the development of more effective hand prostheses.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Petrini FM,Mazzoni A,Rigosa J,Giambattistelli F,Granata G,Barra B,Pampaloni A,Guglielmelli E,Zollo L,Capogrosso M,Micera S,Raspopovic Sdoi
10.1186/s12938-019-0659-9subject
Has Abstractpub_date
2019-04-08 00:00:00pages
44issue
1issn
1475-925Xpii
10.1186/s12938-019-0659-9journal_volume
18pub_type
杂志文章abstract：BACKGROUND:Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-14-S1-S4
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Xenogeneic bone has been widely used in a variety of clinical bone-related disease to promote bone healing and restore bone defects. However, the adverse effects of immune system limit its application in the clinic. The aim of this study was to evaluate xenogeneic bone safety of immunotoxicity and explore th...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-019-0729-z
更新日期：2019-11-14 00:00:00
abstract：BACKGROUND:Studies found that treatment symptoms of concern to oncology/hematology patients were greatly under-identified in medical records. On average, 11.0 symptoms were reported of concern to patients compared to 1.5 symptoms identified in their medical records. A solution to this problem is use of an electronic sy...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-14-S2-S1
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Gait analysis and research have been developed to obtain characteristics of movement patterns of people while walking. However, traditional measuring systems present different drawbacks that reduce their use and application. Among those drawbacks one can find: high price, low sampling frequency and limiting ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-34
更新日期：2014-03-31 00:00:00
abstract：BACKGROUND:Concerns about the cost-effectiveness of invasive hemodynamic monitoring in critically ill patients using pulmonary artery catheters motivate a renewed search for effective noninvasive methods to measure stroke volume. This paper explores a new approach based on noninvasively measured pulse wave velocity, pu...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-137
更新日期：2014-09-19 00:00:00
abstract：BACKGROUND:This paper proposes a methodology for helping bridge the gap between the complex waveform information frequently available in an intensive care unit and the simple, lumped values favoured for rapid clinical diagnosis and management. This methodology employs a simple waveform contour analysis approach to comp...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-018-0603-4
更新日期：2018-11-20 00:00:00
abstract：BACKGROUND:Abnormal blood glucose (BG) concentrations have been associated with increased morbidity and mortality in both critically ill adults and infants. Furthermore, hypoglycaemia and glycaemic variability have both been independently linked to mortality in these patients. Continuous Glucose Monitoring (CGM) device...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-11-45
更新日期：2012-08-06 00:00:00
abstract：BACKGROUND:In order to reduce the radiation dose of CT (computed tomography), compressed sensing theory has been a hot topic since it provides the possibility of a high quality recovery from the sparse sampling data. Recently, the algorithm based on DL (dictionary learning) was developed to deal with the sparse CT reco...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0193-y
更新日期：2016-06-18 00:00:00
abstract：BACKGROUND:Advances in transcranial electrical stimulation (tES) are hampered by the conventional rubber electrodes manually attached to the head with rubber bands. This procedure limits montages to a few electrodes, is error prone with respect to electrode configurations and is burdensome for participants and operator...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-020-00792-1
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:The lumbar range of motion has traditionally been used to assess disability in patients with low back disorders. Controversy exists about how movement ranges in static positions or in a single straight plane is related to the functional status of the patients. The trunk circumduction, as the result of neurom...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-12-4
更新日期：2013-01-11 00:00:00
abstract：BACKGROUND:Classification of breast ultrasound (BUS) images is an important step in the computer-aided diagnosis (CAD) system for breast cancer. In this paper, a novel phase-based texture descriptor is proposed for efficient and robust classifiers to discriminate benign and malignant tumors in BUS images. METHOD:The p...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-015-0022-8
更新日期：2015-03-24 00:00:00
abstract：BACKGROUND:Cerebral hyperperfusion syndrome develops in a small subset of patients following carotid artery surgery (CAS) performed to treat severe carotid artery stenosis. This syndrome has been found to have a close correlation with cerebral hyperperfusion occurring after CAS. The purpose of this study is to investig...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-10-84
更新日期：2011-09-23 00:00:00
abstract：BACKGROUND:Robot-based joint-testing systems (RJTS) can be used to perform unconstrained laxity tests, measuring the stiffness of a degree of freedom (DOF) of the joint at a fixed flexion angle while allowing the other DOFs unconstrained movement. Previous studies using the force-position hybrid (FPH) control method pr...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0195-9
更新日期：2016-06-07 00:00:00
abstract：BACKGROUND:The main problem of tremor is the damage caused to the quality of the life of patients, especially those at more advanced ages. There is not a consensus yet about the origins of this disorder, but it can be examined in the correlations between the biological signs of aging and the tremor characteristics. ME...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-9-29
更新日期：2010-06-22 00:00:00
abstract：BACKGROUND:The anterior cruciate ligament (ACL) plays an important role in stabilizing translation and rotation of the tibia relative to the femur. ACL injury alters knee kinematics and usually links to the alternation of gait patterns. The aim of this study is to develop a new method to distinguish between gait patter...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-018-0594-1
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Assessing hand injury is of great interest given the level of involvement of the hand with the environment. Knowing different assessment systems and their limitations generates new perspectives. The integration of digital systems (accelerometry and electromyography) as a tool to supplement functional assessm...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-161
更新日期：2014-12-11 00:00:00
abstract：BACKGROUND:Tumor hypoxia is involved in every stage of solid tumor development: formation, progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors-chronic hypoxia and acute hypoxia. Recent studies indicate that the regional hypoxia kinetics is closely linked to metastasis and therapeutic responses,...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-016-0235-5
更新日期：2016-10-12 00:00:00
abstract：:A large number of incommensurable metrics are currently used to report the performance of brain-computer interfaces (BCI) used for augmentative and alterative communication (AAC). The lack of standard metrics precludes the comparison of different BCI-based AAC systems, hindering rapid growth and development of this te...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-12-43
更新日期：2013-05-16 00:00:00
abstract：BACKGROUND:Newborn mammals suffering from moderate hypoxia during or after birth are able to compensate a transitory lack of oxygen by adapting their vital functions. Exposure to hypoxia leads to an increase in the sympathetic tone causing cardio-respiratory response, peripheral vasoconstriction and vasodilatation in p...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-10-88
更新日期：2011-10-03 00:00:00
abstract：BACKGROUND:For electroporation-based therapies, accurate modeling of the electric field distribution within the target tissue is important for predicting the treatment volume. In response to conventional, unipolar pulses, the electrical impedance of a tissue varies as a function of the local electric field, leading to ...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-14-S3-S3
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Radio Frequency Identification(RFID) has been widely used in healthcare facilities, but it has been paid little attention whether RFID applications are safe enough under healthcare environment. The purpose of this study is to assess the effects of RFID tags on Magnetic Resonance (MR) imaging in a typical ele...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-129
更新日期：2014-09-04 00:00:00
abstract：BACKGROUND:Analysis of heart rate variation (HRV) has become a popular noninvasive tool for assessing the activities of the autonomic nervous system (ANS). HRV analysis is based on the concept that fast fluctuations may specifically reflect changes of sympathetic and vagal activity. It shows that the structure generati...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-3-24
更新日期：2004-07-20 00:00:00
abstract：BACKGROUND:Mitral valve failure can require repair or replacement. Replacement bioprosthetic valves are treated with glutaraldehyde prior to implantation. The aim of this study was to determine the changes in mechanical properties following glutaraldehyde fixation of mitral valve chordae. METHODS:To investigate the im...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-018-0524-2
更新日期：2018-07-13 00:00:00
abstract：BACKGROUND:This work deals with copyright protection of digital images, an issue that needs protection of intellectual property rights. It is an important issue with a large number of medical images interchanged on the Internet every day. So, it is a challenging task to ensure the integrity of received images as well a...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-015-0101-x
更新日期：2015-11-25 00:00:00
abstract：BACKGROUND:State-of-the-art signal processing methods are known to detect information in single-trial event-related EEG data, a crucial aspect in development of real-time applications such as brain computer interfaces. This paper investigates one such novel approach, evaluating how individual classifier and feature sub...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-6-32
更新日期：2007-08-23 00:00:00
abstract：BACKGROUND:Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid dynamics (CFD) calculations...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-015-0104-7
更新日期：2015-11-26 00:00:00
abstract：BACKGROUND:In a typical electrophysiological experiment, especially one that includes studying animal behavior, the data collected normally contain spikes, local field potentials, behavioral responses and other associated data. In order to obtain informative results, the data must be analyzed simultaneously with the ex...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-017-0419-7
更新日期：2017-11-13 00:00:00
abstract：BACKGROUND:Colonoscopy plays an important role in the clinical screening and management of colorectal cancer. The traditional 'see one, do one, teach one' training style for such invasive procedure is resource intensive and ineffective. Given that colonoscopy is difficult, and time-consuming to master, the use of virtu...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-018-0433-4
更新日期：2018-01-25 00:00:00
abstract：BACKGROUND:The challenges of glycaemic control in critically ill patients have been debated for 20 years. While glycaemic control shows benefits inter- and intra-patient metabolic variability results in increased hypoglycaemia and glycaemic variability, both increasing morbidity and mortality. Hence, current recommenda...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/s12938-019-0720-8
更新日期：2019-10-22 00:00:00
abstract：BACKGROUND:In magnetic resonance electrical impedance tomography (MREIT), we reconstruct conductivity images using magnetic flux density data induced by externally injected currents. Since we extract magnetic flux density data from acquired MR phase images, the amount of measurement noise increases in regions of weak M...
journal_title：Biomedical engineering online
pub_type： 杂志文章
doi：10.1186/1475-925X-13-87
更新日期：2014-06-26 00:00:00
