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Image based evaluation of mediastinal constraints for the development of a pulsatile total artificial heart.

Abstract：

BACKGROUND:Good anatomical compatibility is an important aspect in the development of cardiovascular implants. This work analyzes the interaction of the pump unit of an electrically driven pulsatile Total Artificial Heart (TAH) and the mediastinum. For an adequate compliance, both overall dimensions and alignment of inlets and outlets must be matched. METHODS:Cross-sectional medical image data of 27 individuals, including male and female patients suffering from end stage heart failure, was segmented and reconstructed to three dimensional (3D) surface models. Dimensions and orientations of relevant structures were identified and analyzed. The TAH surface model was virtually placed in orthotopic position and aligned with atrioventricular valves and big vessels. Additionally seven conventional cadaver studies were performed to validate different pump chamber designs based on virtual findings. Thereby 3D-coordinates were captured and introduced to the virtual environment to allow quantitative comparison between different individuals. RESULTS:Spatial parameters varied more in male patients with higher values if heart failure persists. Good correlation of the virtual analysis both to literature data and conventional cadaver studies could be shown. The full data of the 27 individuals as well as the summarized values found in literature are enclosed in the appendix. By superimposing the TAH-volume model to the anatomy, various misalignments were found and the TAH-design was adjusted. CONCLUSIONS:Virtual fitting allows implant design adjustments in realistic anatomy which has not been influenced by thoracotomy. Higher numbers of relevant individuals can be reasonably investigated in the virtual environment and quantitatively correlated. Using this approach, conventional cadaver studies can be significantly reduced but not obviated, due to the unavailable haptic feedback and immobility of potentially compressed structures.

journal_name

Biomed Eng Online

journal_title

Biomedical engineering online

authors

Fritschi AJ,Laumen M,Spiliopoulos S,Finocchiaro T,Egger C,Schmitz-Rode T,Tenderich G,Koerfer R,Steinseifer U

doi

10.1186/1475-925X-12-81

subject

Has Abstract

pub_date

2013-08-14 00:00:00

pages

issn

1475-925X

pii

1475-925X-12-81

journal_volume

pub_type

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Image based evaluation of mediastinal constraints for the development of a pulsatile total artificial heart.