Abstract:
BACKGROUND:Peripheral ECMO is an effective cardiopulmonary support in clinical. The perfusion level could directly influence the performances and complications. However, there are few studies on the effects of the perfusion level on hemodynamics of peripheral ECMO. METHODS:The geometric model of cardiovascular system with peripheral ECMO was established. The blood assist index was used to classify the perfusion level of the ECMO. The flow pattern from the aorta to the femoral artery and their branches, blood flow rate from aorta to brain and limbs, flow interface, harmonic index of blood flow, wall shear stress and oscillatory shear index were chosen to evaluate the hemodynamic effects of peripheral ECMO. RESULTS:The results demonstrated that the flow rate of aorta outlets increased and perfusion condition had been improved. And the average flow to the upper limbs and brain has a positive correlation with BAI (r = 0.037, p < 0.05), while there is a negative correlation with lower limbs (r = - 0.054, p < 0.05). The HI has negative correlation with BAI (p < 0.05, r < 0). The blood interface is further from the heart with the BAI decrease. And the average WSS has negative correlation with BAI (p < 0.05, r = - 0.983) at the bifurcation of femoral aorta and has positive correlation with BAI (p < 0.05, r = 0.99) at the inner aorta. The OSI under different BAI is higher (reaching 0.4) at the inner wall of the aortic arch, the descending aorta and the femoral access. CONCLUSIONS:The pathogenesis of peripheral ECMO with different perfusion levels varies; its further research will be thorough and extensive.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Gu K,Zhang Z,Gao B,Chang Y,Wan Fdoi
10.1186/s12938-018-0493-5subject
Has Abstractpub_date
2018-05-09 00:00:00pages
59issue
1issn
1475-925Xpii
10.1186/s12938-018-0493-5journal_volume
17pub_type
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