Abstract:
BACKGROUND:Cerebral hyperperfusion syndrome develops in a small subset of patients following carotid artery surgery (CAS) performed to treat severe carotid artery stenosis. This syndrome has been found to have a close correlation with cerebral hyperperfusion occurring after CAS. The purpose of this study is to investigate whether and how the anatomy of the Circle of Willis (CoW) of the cerebral circulation influences post-CAS cerebral hyperperfusion. METHODS:A computational model of the cerebral circulation coupled with the global cardiovascular system has been developed to investigate hemodynamic events associated with CAS. Nine topological structures of the CoW were investigated in combination with various distribution patterns of stenosis in the feeding arteries of the cerebral circulation. RESULTS:The occurrence of post-CAS cerebral hyperperfusion was predicted for the CoW structures that have poor collateral pathways between the stenosed cerebral feeding arteries and the remaining normal feeding arteries. The risk and the localization of post-CAS hyperperfusion were determined jointly by the anatomy of the CoW and the distribution pattern of stenosis in the cerebral feeding arteries. The presence of basilar artery stenosis or contralateral ICA stenosis increased the risk of post-CAS hyperperfusion and enlarged the cerebral region affected by hyperperfusion. For a certain CoW structure, the diameters of the cerebral communicating arteries and the severity of carotid artery stenosis both had a significant influence on the computed post-CAS cerebral hyperperfusion rates. Moreover, post-CAS cerebral hyperperfusion was predicted to be accompanied with an excessively high capillary transmural pressure. CONCLUSIONS:This study demonstrated the importance of considering the anatomy of the CoW in assessing the risk of post-CAS cerebral hyperperfusion. Particularly, since the anatomy of the CoW and the distribution pattern of stenosis in the cerebral feeding arteries jointly determine the risk and localization of post-CAS cerebral hyperperfusion, a patient-specific hemodynamic analysis aimed to help physicians identify patients at high risk of cerebral hyperperfusion should account for the combined effect of the anatomy of cerebral arteries and cerebral feeding artery stenoses on cerebral hemodynamics.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Liang F,Fukasaku K,Liu H,Takagi Sdoi
10.1186/1475-925X-10-84subject
Has Abstractpub_date
2011-09-23 00:00:00pages
84issn
1475-925Xpii
1475-925X-10-84journal_volume
10pub_type
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