Abstract:
BACKGROUND:Tumor hypoxia is involved in every stage of solid tumor development: formation, progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors-chronic hypoxia and acute hypoxia. Recent studies indicate that the regional hypoxia kinetics is closely linked to metastasis and therapeutic responses, but regional hypoxia kinetics is hard to measure. We propose a novel approach to determine the local pO2 by fusing the parameters obtained from in vivo functional imaging through the use of a modified multivariate Krogh model. METHODS:To test our idea and its potential to translate into an in vivo setting through the use of existing imaging techniques, simulation studies were performed comparing the local partial oxygen pressure (pO2) from the proposed multivariate image fusion model to the referenced pO2 derived by Green's function, which considers the contribution from every vessel segment of an entire three-dimensional tumor vasculature to profile tumor oxygen with high spatial resolution. RESULTS:pO2 derived from our fusion approach were close to the referenced pO2 with regression slope near 1.0 and an r2 higher than 0.8 if the voxel size (or the spatial resolution set by functional imaging modality) was less than 200 μm. The simulation also showed that the metabolic rate, blood perfusion, and hemoglobin concentration were dominant factors in tissue oxygenation. The impact of the measurement error of functional imaging to the pO2 precision and accuracy was simulated. A Gaussian error function with FWHM equal to 20 % of blood perfusion or fractional vascular volume measurement contributed to average 7 % statistical error in pO2. CONCLUSION:The simulation results indicate that the fusion of multiple parametric maps through the biophysically derived mathematical models can monitor the intra-tumor spatial variations of hypoxia in tumors with existing imaging methods, and the potential to further investigate different forms of hypoxia, such as chronic and acute hypoxia, in response to cancer therapies.
journal_name
Biomed Eng Onlinejournal_title
Biomedical engineering onlineauthors
Lee CW,Stantz KMdoi
10.1186/s12938-016-0235-5subject
Has Abstractpub_date
2016-10-12 00:00:00pages
114issue
1issn
1475-925Xpii
10.1186/s12938-016-0235-5journal_volume
15pub_type
杂志文章abstract:BACKGROUND:The biomechanical simulation of the human respiratory system is expected to be a useful tool for the diagnosis and treatment of respiratory diseases. Because the deformation of the thorax significantly influences airflow in the lungs, we focused on simulating the thorax deformation by introducing contraction...
journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0132-y
更新日期:2016-02-06 00:00:00
abstract:BACKGROUND:A valveless pump generates a unidirectional net flow of fluid around a closed loop of soft viscoelastic tubing that is rhythmically compressed at one point. The tubing must have at least two sections with two different stiffnesses. When a short segment of the tube is squeezed asymmetrically at certain freque...
journal_title:Biomedical engineering online
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journal_title:Biomedical engineering online
pub_type: 杂志文章
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925x-1-5
更新日期:2002-11-13 00:00:00
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journal_title:Biomedical engineering online
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journal_title:Biomedical engineering online
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journal_title:Biomedical engineering online
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journal_title:Biomedical engineering online
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journal_title:Biomedical engineering online
pub_type: 杂志文章
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journal_title:Biomedical engineering online
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更新日期:2019-07-25 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0573-6
更新日期:2018-11-06 00:00:00
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journal_title:Biomedical engineering online
pub_type: 评论,信件
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更新日期:2011-09-11 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-12-105
更新日期:2013-10-14 00:00:00
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journal_title:Biomedical engineering online
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doi:10.1186/1475-925X-10-11
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pub_type: 杂志文章
doi:10.1186/1475-925X-6-19
更新日期:2007-05-31 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-9-27
更新日期:2010-06-18 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-018-0441-4
更新日期:2018-01-29 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/s12938-016-0143-8
更新日期:2016-03-08 00:00:00
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doi:10.1186/1475-925X-13-146
更新日期:2014-10-21 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
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更新日期:2019-11-14 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-11-52
更新日期:2012-08-21 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-9-56
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journal_title:Biomedical engineering online
pub_type: 杂志文章
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journal_title:Biomedical engineering online
pub_type: 杂志文章
doi:10.1186/1475-925X-10-23
更新日期:2011-04-03 00:00:00
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journal_title:Biomedical engineering online
pub_type: 杂志文章,评审
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