Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders.

abstract：:Leptin plays a key role in obstructive sleep apnea syndrome (OSAS). Leptin production in human airways has been previously evaluated by measuring leptin concentration in the exhaled breath condensate and in the induced sputum. The aim was to study leptin expression in the cells of induced sputum and in exhaled breath ...

journal_title：Journal of breath research

authors： Carpagnano GE,Resta O,Pergola GD,Sabato R,Foschino Barbaro MP

更新日期：2010-09-01 00:00:00

abstract：:This study aimed to analyze the impact of chewing gum on halitosis parameters. Three databases were searched with the following focused question: 'Can chewing gum additionally reduce halitosis parameters, such as organoleptic scores and volatile sulfur compounds (VSC), when compared to a control treatment'? Controlled...

journal_title：Journal of breath research

authors： Muniz FW,Friedrich SA,Silveira CF,Rösing CK

更新日期：2017-02-17 00:00:00

abstract：:While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...

journal_title：Journal of breath research

authors： Singh KD,Del Miguel GV,Gaugg MT,Ibañez AJ,Zenobi R,Kohler M,Frey U,Sinues PM

更新日期：2018-02-07 00:00:00

abstract：:Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...

journal_title：Journal of breath research

authors： Tarnoki DL,Tarnoki AD,Medda E,Littvay L,Lazar Z,Toccaceli V,Fagnani C,Stazi MA,Nisticó L,Brescianini S,Penna L,Lucatelli P,Boatta E,Zini C,Fanelli F,Baracchini C,Meneghetti G,Koller A,Osztovits J,Jermendy G,Preda

更新日期：2013-06-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) is a common bacterium infecting children with cystic fibrosis (CF). Since current detection methods are difficult to perform in children, there is need for an alternative. This proof of concept study investigates whether breath profiles can discriminate between S. aureus infected and ...

journal_title：Journal of breath research

authors： Neerincx AH,Geurts BP,van Loon J,Tiemes V,Jansen JJ,Harren FJ,Kluijtmans LA,Merkus PJ,Cristescu SM,Buydens LM,Wevers RA

更新日期：2016-11-30 00:00:00

abstract：:In the current pilot study we aimed to determine whether breath analysis could be used to help recognise intra-abdominal infection, using acute appendicitis as an exemplar condition. Our study included 53 patients (aged 18-88 years) divided into three groups: appendix group, 26 (13 male) patients suffering from acute ...

journal_title：Journal of breath research

authors： Andrews BT,Das P,Denzer W,Ritchie GA,Peverall R,Hamade AM,Hancock G

更新日期：2020-10-22 00:00:00

abstract：:In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a...

journal_title：Journal of breath research

authors： Kramer C,Mochalski P,Unterkofler K,Agapiou A,Ruzsanyi V,Liedl KR

更新日期：2016-01-27 00:00:00

abstract：:Tongue coating (TC) mainly consists of protein mostly from exfoliated epithelial cells. Until now, to reduce TC accumulation, only mechanical measures have been available, and the procedure involves unpleasant side effects, such as gagging reflex or carcinogenesis related to mechanical stimulation. We expected that pr...

journal_title：Journal of breath research

authors： Nohno K,Yamaga T,Kaneko N,Miyazaki H

更新日期：2012-03-01 00:00:00

abstract：:Nitrative stress is thought to be involved in the inflammatory process in COPD airways, and the alveolar nitric oxide concentration (CAlv) has been reported to be increased. However, the CAlv levels are also regulated by gas diffusion at alveolar sites. The aim of the study was to assess the relationship between the C...

journal_title：Journal of breath research

authors： Hirano T,Matsunaga K,Sugiura H,Minakata Y,Koarai A,Akamatsu K,Ichikawa T,Furukawa K,Ichinose M

更新日期：2013-12-01 00:00:00

abstract：:Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid an...

journal_title：Journal of breath research

authors： Uchida M,Yoshida K,Shimizu K

更新日期：2009-12-01 00:00:00

abstract：:Despite recent progress in Critical Care Medicine, sepsis is still a major medical problem with a high rate of mortality and morbidity especially in intensive care units. Oxidative stress induced by inflammation associated with sepsis causes degradation of heme protein, increases microsomal free heme content, promotes...

journal_title：Journal of breath research

authors： Morimatsu H,Takahashi T,Matsusaki T,Hayashi M,Matsumi J,Shimizu H,Matsumi M,Morita K

更新日期：2010-12-01 00:00:00

abstract：:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...

journal_title：Journal of breath research

authors： Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled N

更新日期：2016-06-07 00:00:00

abstract：:The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...

journal_title：Journal of breath research

authors： Boshier PR,Hanna GB,Marczin N

更新日期：2013-03-01 00:00:00

abstract：:Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly re...

journal_title：Journal of breath research

authors： Karvonen T,Sepponen-Lavikko A,Holm K,Schultz R,Moilanen E,Lehtimäki L

更新日期：2020-11-05 00:00:00

abstract：:Concentrations of exhaled volatile organic compounds (VOCs) may depend not only on biochemical or pathologic processes but also on physiological parameters. As breath sampling may be done in different body positions, effects of the sampling position on exhaled VOC concentrations were investigated by means of real-time...

journal_title：Journal of breath research

authors： Sukul P,Trefz P,Kamysek S,Schubert JK,Miekisch W

更新日期：2015-11-19 00:00:00

abstract：:Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three ...

journal_title：Journal of breath research

authors： Cui Y,Pi X,Wang C,Liu S,Gong Y,Wang Y,Zhang F,Shi J,Lin Z,Zhang X,Li E

更新日期：2015-02-26 00:00:00

abstract：:The human genome is the counterpart to the human exposome with respect to the gene × environment interaction that describes health state and outcome. The genome has already been sequenced and is in the process of being assessed for specific functionality; to similarly decode the exposome will require the measurement a...

journal_title：Journal of breath research

authors： Pleil JD,Stiegel MA,Sobus JR

更新日期：2011-12-01 00:00:00

abstract：:The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...

journal_title：Journal of breath research

authors： Tan BK,Davies SJ,Spaněl P,Smith D

更新日期：2012-09-01 00:00:00

abstract：:The haloamines, including the chloramines (H(2)NCl, HNCl(2)) and bromamine (H(2)NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid sampl...

journal_title：Journal of breath research

authors： Storer MK,Dummer JD,Cook J,McEwan M,Epton MJ

更新日期：2011-09-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer-related deaths worldwide, and is considered one of the most aggressive human cancers, with a 5 year overall survival of 10-15%. Early diagnosis of lung cancer is ideal; however, it is still uncertain as to what technique will prove successful in the systematic screening of high...

journal_title：Journal of breath research

authors： Hayes SA,Haefliger S,Harris B,Pavlakis N,Clarke SJ,Molloy MP,Howell VM

更新日期：2016-07-05 00:00:00

abstract：:Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic al...

journal_title：Journal of breath research

authors： Thorn RM,Greenman J

更新日期：2012-06-01 00:00:00

abstract：:There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of ...

journal_title：Journal of breath research

authors： Gould O,Wieczorek T,de Lacy Costello B,Persad R,Ratcliffe N

更新日期：2017-12-06 00:00:00

abstract：:Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in...

journal_title：Journal of breath research

authors： Hannemann M,Antufjew A,Borgmann K,Hempel F,Ittermann T,Welzel S,Weltmann KD,Völzke H,Röpcke J

更新日期：2011-06-01 00:00:00

abstract：:Selected volatile organic compounds (VOCs) in breath may be considered biomarkers if they are indicative of distinct diseases or disease states. Given the inherent molecular selectivity of vibrational spectroscopy, infrared sensing technologies appear ideally suitable for the determination of endogenous VOCs in breath...

journal_title：Journal of breath research

authors： Perez-Guaita D,Kokoric V,Wilk A,Garrigues S,Mizaikoff B

更新日期：2014-06-01 00:00:00

abstract：:Experimental studies using trained dogs to identify breath odour markers of human cancer, published in the recent decade, have been analyzed and compared with the authors' own results. Particular published studies differ as regards the experimental setup, kind of odour samples (breath, urine, tumor tissue, serum), sam...

journal_title：Journal of breath research

authors： Jezierski T,Walczak M,Ligor T,Rudnicka J,Buszewski B

更新日期：2015-05-06 00:00:00

abstract：:The objective of this study is to evaluate tonsil odor as a contributor to halitosis and to study the reduction of oral malodor by mouth rinsing, without tonsil treatment. In 48 halitosis patients, tonsil odor and oral malodor were assessed through the 0-5 scale. In tonsil odor assessment, a dental burnisher was inser...

journal_title：Journal of breath research

authors： Talebian A,Tazhibi M,Iranpoor R,Semyari H,Taherzadeh M

更新日期：2008-03-01 00:00:00

abstract：:Rodent and nonhuman primate studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed i...

journal_title：Journal of breath research

authors： Bishop AC,Libardoni M,Choudary A,Misra B,Lange K,Bernal J,Nijland M,Li C,Olivier M,Nathanielsz PW,Cox LA

更新日期：2018-05-14 00:00:00

abstract：:Despite growing interest and considerable progress in breath research over the last decade, standardized practices for the sampling and analysis of breath gas volatiles remain elusive. The primary reasons for this are (a) the rich chemical diversity of exhaled breath that covers an extensive range of volatile organic ...

journal_title：Journal of breath research

authors： Herbig J,Beauchamp J

更新日期：2014-09-01 00:00:00

abstract：:Exhaled breath condensate (EBC) is increasingly being used as a non-invasive method for disease diagnosis and environmental exposure assessment. We previously detected the nucleic acids of bacterial pathogens in EBC. Influenza viruses can be transmitted through aerosols during coughing and exhaling. Existing detection...

journal_title：Journal of breath research

authors： Li X,Wang M,Chen J,Lin F,Wang W

更新日期：2021-01-12 00:00:00

abstract：:Robust methods for breath sampling and analysis are required for potential clinical applications. We have evaluated an improved sampling and experimental design, assessing instrumental and biological variability within and across breath measurements. Calibration curves for selected relevant volatile organic compounds...

journal_title：Journal of breath research

authors： Basanta M,Ibrahim B,Douce D,Morris M,Woodcock A,Fowler SJ

更新日期：2012-06-01 00:00:00