Abstract:
:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGTT) to determine if tumor cells' hyperglycolysis would affect the volatile signature. Blood glucose levels and exhaled breath samples were analyzed before the OGTT, and 90 min after, in both LC patients and controls. The volatile signature was measured by proton transfer reaction mass spectrometry (PTR-MS). Twenty-two LC patients (age 66.6 ± 12.7) with adenocarcinoma (n = 14), squamous (n = 6), small cell carcinoma (n = 2), and twenty-one controls (age 54.4 ± 13.7; 10 non-smokers and 11 smokers) were included. All LC patients showed a hyperglycolytic state in their FDG-PET scans. Both baseline and post OGTT volatile signatures discriminate between the groups. The OGTT has a minimal effect in LC (a decrease in m/z 54 by 39%, p v = 0.0499); whereas in the control group, five masses (m/z 64, 87,88, 142 and 161) changed by -13%, -49%, -40% and -29% and 46% respectively. To conclude, OGTT has a minimal effect on the VOC signature in LC patients, where a hyperglycolytic state already exists. In contrast, in the control group the OGTT has a profound effect in which induced hyperglycolysis significantly changed the VOC pattern. We hypothesized that a ceiling effect in cancerous patients is responsible for this discrepancy.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled Ndoi
10.1088/1752-7155/10/2/026012subject
Has Abstractpub_date
2016-06-07 00:00:00pages
026012issue
2eissn
1752-7155issn
1752-7163journal_volume
10pub_type
杂志文章abstract::In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/017103
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/3/037009
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journal_title:Journal of breath research
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doi:10.1088/1752-7155/10/3/036009
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abstract::Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) represents an attractive tool for the real-time analysis of VOC profiles in human breath. Quantification of breath VOCs by means of direct MS may be affected by the matrix, as human breath not only contains several hundred VOCs at the ppbV-pptV lev...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa9eea
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abstract::Tongue coating (TC) mainly consists of protein mostly from exfoliated epithelial cells. Until now, to reduce TC accumulation, only mechanical measures have been available, and the procedure involves unpleasant side effects, such as gagging reflex or carcinogenesis related to mechanical stimulation. We expected that pr...
journal_title:Journal of breath research
pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7155/6/1/017107
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abstract::Early detection of lung cancer (LC) is a priority since LC is characterized by symptoms mimicking other respiratory conditions, but it remains the leading cause of oncological disease death. Properly trained dogs can perceive the volatile organic compounds (VOCs) related to cancer thanks to their acute sense of smell....
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab716e
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
abstract::The objective of this study is to evaluate tonsil odor as a contributor to halitosis and to study the reduction of oral malodor by mouth rinsing, without tonsil treatment. In 48 halitosis patients, tonsil odor and oral malodor were assessed through the 0-5 scale. In tonsil odor assessment, a dental burnisher was inser...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017016
更新日期:2008-03-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,meta分析,评审
doi:10.1088/1752-7163/aa5cc2
更新日期:2017-02-17 00:00:00
abstract:BACKGROUND:The analysis of volatile organic compounds (VOCs) in breath allows non-invasive investigations of diseases. Animal studies are conducted as a model to perform research of VOCs and their relation to diseases. In large animal models ruminants were often used as experimental targets. The effect of their physiol...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aabdaf
更新日期:2018-05-14 00:00:00
abstract::A point-of-care, non-invasive, low-cost and sensitive nano-biodiagnostic is needed in today's age for rapid and accurate self-diagnosis as well as for the management of asthma, which is advantageous for low resource areas where asthma is prevalent. The objective of this research work was to prepare the miniature, nano...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab1faf
更新日期:2019-06-25 00:00:00
abstract::Methods for breath sampling and analysis require robust quality assessment to minimise the risk of false discoveries. Planning large-scale multi-site breath metabolite profiling studies also requires careful consideration of systematic and random variation as a result of sampling and analysis techniques. In this study...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aae557
更新日期:2018-10-30 00:00:00
abstract::This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017006
更新日期:2008-03-01 00:00:00
abstract::The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/7/1/017118
更新日期:2013-03-01 00:00:00
abstract::Despite growing interest and considerable progress in breath research over the last decade, standardized practices for the sampling and analysis of breath gas volatiles remain elusive. The primary reasons for this are (a) the rich chemical diversity of exhaled breath that covers an extensive range of volatile organic ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/3/037101
更新日期:2014-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/4/046002
更新日期:2014-09-18 00:00:00
abstract::Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...
journal_title:Journal of breath research
pub_type: 历史文章,杂志文章,评审
doi:10.1088/1752-7155/7/3/037109
更新日期:2013-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac5a5
更新日期:2018-06-08 00:00:00
abstract::Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid an...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/4/047003
更新日期:2009-12-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/10/4/047103
更新日期:2016-12-17 00:00:00
abstract::Despite recent progress in Critical Care Medicine, sepsis is still a major medical problem with a high rate of mortality and morbidity especially in intensive care units. Oxidative stress induced by inflammation associated with sepsis causes degradation of heme protein, increases microsomal free heme content, promotes...
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pub_type: 杂志文章
doi:10.1088/1752-7155/4/4/047103
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/1/016005
更新日期:2016-02-01 00:00:00
abstract::The analysis of exhaled breath is drawing a high degree of interest in the diagnostics of various diseases, including lung cancer. Electronic nose (E-nose) technology is one of the perspective approaches in the field due to its relative simplicity and cost efficiency. The use of an E-nose together with pattern recogni...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab433d
更新日期:2019-10-23 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed to verify to which extent exhaled VOCs can characterize new...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac273
更新日期:2018-06-08 00:00:00
abstract::Volatile organic compounds (VOCs) in exhaled breath originate from current or previous environmental exposures (exogenous compounds) and internal metabolic (anabolic and catabolic) production (endogenous compounds). The origins of certain VOCs in breath presumed to be endogenous have been proposed to be useful as prec...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/1/017107
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Asthma control does not yet meet the goals of asthma management guidelines. Non-invasive monitoring of airway inflammation may help to improve the level of asthma control in children. OBJECTIVES:(1) To identify a set of exhaled volatile organic compounds (VOCs) that is most predictive for an asthma exacerba...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa5a8b
更新日期:2017-03-01 00:00:00
abstract::Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R = 90. In this study, we ...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026004
更新日期:2016-04-08 00:00:00
abstract::Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic al...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/6/2/024001
更新日期:2012-06-01 00:00:00
abstract::While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of ...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7163/aa9ee3
更新日期:2018-02-07 00:00:00
abstract::Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046008
更新日期:2016-10-12 00:00:00