Abstract:
:There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of VCs) remain largely unreported. This paper addresses that issue by comparing the response of a metal oxide sensor directly with a mass spectrometer (MS), whereby both detectors are interfaced to the same GC column using an s-swafer. It was demonstrated that the sensitivity of an in-house fabricated ZnO/SnO2 thick film MOS was superior to a modern MS for the detection of a wide range of volatile compounds (VCs) of different functionalities and masses. Better techniques for detection and quantification of these VCs is valuable, as many of these compounds are commonly reported throughout the scientific literature. This is also the first published report of a combined GC-MS sensor system. These two different detector technologies when combined, should enhance discriminatory abilities to aid disease diagnoses using volatiles from e.g. breath, and bodily fluids. Twenty-nine chemical standards have been tested using solid phase micro-extraction; 25 of these compounds are found on human breath. In all but two instances the sensor exhibited the same or superior limit of detection compared to the MS. Twelve stool samples from healthy participants were analysed; the sensor detected, on average 1.6 peaks more per sample than the MS. Similarly, analysing the headspace of E. coli broth cultures the sensor detected 6.9 more peaks per sample versus the MS. This greater sensitivity is primarily a function of the superior limits of detection of the metal oxide sensor. This shows that systems based on the combination of chromatography systems with solid state sensors shows promise for a range of applications.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Gould O,Wieczorek T,de Lacy Costello B,Persad R,Ratcliffe Ndoi
10.1088/1752-7163/aa8efesubject
Has Abstractpub_date
2017-12-06 00:00:00pages
016009issue
1eissn
1752-7155issn
1752-7163journal_volume
12pub_type
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/4/046001
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journal_title:Journal of breath research
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doi:10.1088/1752-7155/7/4/046002
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journal_title:Journal of breath research
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doi:10.1088/1752-7163/aaba84
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/1/1/014004
更新日期:2007-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa7957
更新日期:2017-09-13 00:00:00
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journal_title:Journal of breath research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-12-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/2/026001
更新日期:2014-06-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/6/3/036005
更新日期:2012-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abba6c
更新日期:2020-10-31 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026008
更新日期:2016-04-27 00:00:00
abstract::Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly re...
journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abc054
更新日期:2020-11-05 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/5/3/037111
更新日期:2011-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/ab1faf
更新日期:2019-06-25 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/2/027005
更新日期:2009-06-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/10/3/034001
更新日期:2016-07-05 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac273
更新日期:2018-06-08 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/8/2/027103
更新日期:2014-06-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aac5a5
更新日期:2018-06-08 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/2/026005
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/8/4/046002
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/4/047003
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pub_type: 杂志文章,随机对照试验
doi:10.1088/1752-7155/6/1/017107
更新日期:2012-03-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/abba88
更新日期:2020-10-22 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/3/1/016002
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/4/4/047103
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017006
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/3/036006
更新日期:2016-07-13 00:00:00
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/4/046008
更新日期:2016-10-12 00:00:00
abstract::Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessing malabsorption of sugars in the small intestine. However, there are...
journal_title:Journal of breath research
pub_type: 杂志文章,评审
doi:10.1088/1752-7155/7/2/024001
更新日期:2013-06-01 00:00:00