Abstract:
:Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly reduce after the commencement of inhaled corticosteroid (ICS) treatment. However, little is known on the effect of ICS on the other NO parameters. We assessed (1) the onset of action of ICS treatment on the NO parameters and (2) whether the changes in bronchial NO output are due to changes in bronchial wall NO concentration or diffusion factor. FENO and other NO parameters were measured at baseline and after 1, 3 and 7 d of treatment with inhaled fluticasone propionate 250 μg b.i.d. in 23 allergic children with a history of asthma-like symptoms. There was a decrease in J awNO (from 680 (244/1791) (median (1st/3rd quartile)) to 357 (165/753) pl s-1, p < 0.001) and FENO50( from 13.8 (7.5/35) to 8.3 (5.36/17.0) ppb, p < 0.001) in 3 d from the first dose of ICS. Also, C awNO seemed to reduce after 3 d (from 171 (89/328) to 79 (54/157) ppb, p = 0.041), while D awNO remained unchanged. Furthermore, C ANO reduced during the 7 d treatment (from 3.0 (2.0/5.0) to 2.3 (1.9/2.6) ppb, p = 0.004). ICS treatment reduced FENO50 and J awNO rapidly and the decline was caused by decreased bronchial wall NO concentration while bronchial NO diffusion factor remained unchanged. These findings suggest that C awNO could be a more specific marker of airway inflammation and treatment response than J awNO or FENO50, which are both determined also by D awNO that seems to be resistant to the treatment with ICS.
journal_name
J Breath Resjournal_title
Journal of breath researchauthors
Karvonen T,Sepponen-Lavikko A,Holm K,Schultz R,Moilanen E,Lehtimäki Ldoi
10.1088/1752-7163/abc054subject
Has Abstractpub_date
2020-11-05 00:00:00pages
016008issue
1eissn
1752-7155issn
1752-7163journal_volume
15pub_type
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/2/1/017006
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journal_title:Journal of breath research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aa7957
更新日期:2017-09-13 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-02-26 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/3/037102
更新日期:2013-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7163/aba816
更新日期:2020-10-24 00:00:00
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journal_title:Journal of breath research
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026012
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doi:10.1088/1752-7155/4/4/047103
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pub_type: 杂志文章,评审
doi:10.1088/1752-7155/10/3/034001
更新日期:2016-07-05 00:00:00
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/4/1/017105
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1088/1752-7155/8/4/046002
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pub_type: 杂志文章
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journal_title:Journal of breath research
pub_type: 杂志文章,评审
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/1/1/014004
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/3/036009
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/10/2/026004
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journal_title:Journal of breath research
pub_type: 杂志文章
doi:10.1088/1752-7155/7/1/017107
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