Off-line breath acetone analysis in critical illness.

abstract：:Exhaled air contains sub-micron droplets of lung liquid, which potentially bear biomarkers of lung diseases. After dehydration they form dry residue particles (DRPs). As a first step in developing techniques to characterize individual DRPs, a new electrostatic collector was designed in which DRPs are charged within a ...

journal_title：Journal of breath research

authors： Morozov VN,Mikheev AY

更新日期：2017-01-09 00:00:00

abstract：:The results of experiments are described in which a known quantity of sterile deuterated water is injected directly into the pulmonary circulation via the right internal jugular vein of several haemodialysis patients and the deuterium to hydrogen ratio, D/H, in the exhaled lung water was measured using the flowing aft...

journal_title：Journal of breath research

authors： Tan BK,Davies SJ,Spaněl P,Smith D

更新日期：2012-09-01 00:00:00

abstract：:Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...

journal_title：Journal of breath research

authors： Wang Z,Wang C

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The analysis of volatile organic compounds (VOCs) in breath allows non-invasive investigations of diseases. Animal studies are conducted as a model to perform research of VOCs and their relation to diseases. In large animal models ruminants were often used as experimental targets. The effect of their physiol...

journal_title：Journal of breath research

authors： Oertel P,Küntzel A,Reinhold P,Köhler H,Schubert JK,Kolb J,Miekisch W

更新日期：2018-05-14 00:00:00

abstract：:Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...

journal_title：Journal of breath research

authors： McCartney MM,Thompson CJ,Klein LR,Ngo JH,Seibel JD,Fabia F,Simms LA,Borras E,Young BS,Lara J,Turnlund MW,Nguyen AP,Kenyon NJ,Davis CE

更新日期：2020-07-21 00:00:00

abstract：:The forehead was studied as a possible sampling site for capturing changes in volatile organic compound (VOC) profiles associated with psychological-stress. Skin-VOCs were sampled with a polydimethylsilicone (PDMS)-coupon and the resulting VOCs were recovered and analysed with two-stage thermal desorption gas chromato...

journal_title：Journal of breath research

authors： Martin HJ,Turner MA,Bandelow S,Edwards L,Riazanskaia S,Thomas CL

更新日期：2016-11-21 00:00:00

abstract：:Fractional exhaled nitric oxide (FENO) is a marker of airway inflammation. Measuring FENO at multiple flow rates enables calculation of NO parameters: bronchial NO output (J awNO), bronchial wall (C awNO) and alveolar (C ANO) NO concentrations, and bronchial diffusion factor of NO (D awNO). FENO is known to rapidly re...

journal_title：Journal of breath research

authors： Karvonen T,Sepponen-Lavikko A,Holm K,Schultz R,Moilanen E,Lehtimäki L

更新日期：2020-11-05 00:00:00

abstract：:The discovery of nitric oxide (NO) as a signalling and regulatory molecule and its subsequent detection in the exhaled breath has not only yielded new mechanistic insights but also diagnostic opportunities and therapeutic targets in several important medical conditions. In diseases involving chronic pulmonary inflamma...

journal_title：Journal of breath research

authors： Boshier PR,Hanna GB,Marczin N

更新日期：2013-03-01 00:00:00

abstract：:Breath contains hundreds of volatile organic compounds (VOCs), the composition of which is altered in a wide variety of diseases. Bacteria are implicated in the formation of VOCs, but the biochemical mechanisms that lead to the formation of breath VOCs remain largely hypothetical. We hypothesized that bacterial DNA fr...

journal_title：Journal of breath research

authors： Bos LD,Meinardi S,Blake D,Whiteson K

更新日期：2016-12-17 00:00:00

abstract：:Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...

journal_title：Journal of breath research

authors： Plantier L,Debray MP,Estellat C,Flamant M,Roy C,Bancal C,Borie R,Israël-Biet D,Mal H,Crestani B,Delclaux C

更新日期：2016-02-01 00:00:00

abstract：:There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of ...

journal_title：Journal of breath research

authors： Gould O,Wieczorek T,de Lacy Costello B,Persad R,Ratcliffe N

更新日期：2017-12-06 00:00:00

abstract：:Profiling the body chemistry by means of volatile organic compounds (VOCs) in the breath opens exciting new avenues in medical diagnostics. Gas sensors could provide ideal platforms for realizing portable, hand-held breath testing devices in the near future. This review summarizes the latest developments and applicati...

journal_title：Journal of breath research

authors： Tisch U,Haick H

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed to verify to which extent exhaled VOCs can characterize new...

journal_title：Journal of breath research

authors： Scarlata S,Finamore P,Santangelo S,Giannunzio G,Pennazza G,Grasso S,Santonico M,Incalzi RA

更新日期：2018-06-08 00:00:00

abstract：:Microbial cultures and/or microbial associated diseases often have a characteristic smell. Volatile organic compounds (VOCs) are produced by all microorganisms as part of their normal metabolism. The types and classes of VOC produced is wide, including fatty acids and their derivatives (e.g. hydrocarbons, aliphatic al...

journal_title：Journal of breath research

authors： Thorn RM,Greenman J

更新日期：2012-06-01 00:00:00

abstract：:Radiation dose is important in radiotherapy. Too little, and the treatment is not effective, too much causes radiation toxicity. A biochemical measurement of the effect of radiotherapy would be useful in personalisation of this treatment. This study evaluated changes in exhaled breath volatile organic compounds (VOC) ...

journal_title：Journal of breath research

authors： Salman D,Eddleston M,Darnley K,Nailon WH,McLaren DB,Hadjithelki A,Ruszkiewicz D,Langejuergen J,Alkhalifa Y,Phillips I,Thomas CLP

更新日期：2020-10-24 00:00:00

abstract：:Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we ...

journal_title：Journal of breath research

authors： Allers M,Langejuergen J,Gaida A,Holz O,Schuchardt S,Hohlfeld JM,Zimmermann S

更新日期：2016-04-08 00:00:00

abstract：:Experimental studies using trained dogs to identify breath odour markers of human cancer, published in the recent decade, have been analyzed and compared with the authors' own results. Particular published studies differ as regards the experimental setup, kind of odour samples (breath, urine, tumor tissue, serum), sam...

journal_title：Journal of breath research

authors： Jezierski T,Walczak M,Ligor T,Rudnicka J,Buszewski B

更新日期：2015-05-06 00:00:00

abstract：:Selected volatile organic compounds (VOCs) in breath may be considered biomarkers if they are indicative of distinct diseases or disease states. Given the inherent molecular selectivity of vibrational spectroscopy, infrared sensing technologies appear ideally suitable for the determination of endogenous VOCs in breath...

journal_title：Journal of breath research

authors： Perez-Guaita D,Kokoric V,Wilk A,Garrigues S,Mizaikoff B

更新日期：2014-06-01 00:00:00

abstract：:The design, realization and testing of a CO(2)-triggered breath sampler, capable of a separate collection of dead space and end-tidal air on multiple breaths, is presented. This sampling procedure has advantages in terms of the sample volume, insights regarding the origin of compounds, increased reproducibility and hi...

journal_title：Journal of breath research

authors： Di Francesco F,Loccioni C,Fioravanti M,Russo A,Pioggia G,Ferro M,Roehrer I,Tabucchi S,Onor M

更新日期：2008-09-01 00:00:00

abstract：:Despite recent progress in Critical Care Medicine, sepsis is still a major medical problem with a high rate of mortality and morbidity especially in intensive care units. Oxidative stress induced by inflammation associated with sepsis causes degradation of heme protein, increases microsomal free heme content, promotes...

journal_title：Journal of breath research

authors： Morimatsu H,Takahashi T,Matsusaki T,Hayashi M,Matsumi J,Shimizu H,Matsumi M,Morita K

更新日期：2010-12-01 00:00:00

abstract：:Exhaled breath condensate (EBC) is increasingly being used as a non-invasive method for disease diagnosis and environmental exposure assessment. We previously detected the nucleic acids of bacterial pathogens in EBC. Influenza viruses can be transmitted through aerosols during coughing and exhaling. Existing detection...

journal_title：Journal of breath research

authors： Li X,Wang M,Chen J,Lin F,Wang W

更新日期：2021-01-12 00:00:00

abstract：:The sensitivity of selected ion flow tube mass spectrometry, SIFT-MS, has been increased such that it is now possible to detect metabolites present at a part-per-billion, ppb, level in single breath exhalations. However, to utilize this improved sensitivity, the overlaps (coincidences) of those ions resulting from int...

journal_title：Journal of breath research

authors： Spaněl P,Smith D

更新日期：2008-12-01 00:00:00

abstract：:Volatile organic compounds (VOCs) in exhaled human breath can serve as potential disease-specific and exposure biomarkers and therefore can reveal information about a subject's health and environment. Pyridine, a VOC marker for exposure to tobacco smoke, and isoprene, a liver disease biomarker, were studied using atmo...

journal_title：Journal of breath research

authors： Kapishon V,Koyanagi GK,Blagojevic V,Bohme DK

更新日期：2013-06-01 00:00:00

abstract：:Breath analysis represents a new frontier in medical diagnosis and a powerful tool for cancer biomarker discovery due to the recent development of analytical platforms for the detection and identification of human exhaled volatile compounds. Statistical and bioinformatic tools may represent an effective complement to ...

journal_title：Journal of breath research

authors： Martinez-Lozano Sinues P,Landoni E,Miceli R,Dibari VF,Dugo M,Agresti R,Tagliabue E,Cristoni S,Orlandi R

更新日期：2015-09-21 00:00:00

abstract：:In this article, a database of blood:air and fat:air partition coefficients (λ b:a and λ f:a) is reported for estimating 1678 volatile organic compounds recently reported to appear in the volatilome of the healthy human. For this purpose, a quantitative structure-property relationship (QSPR) approach was applied and a...

journal_title：Journal of breath research

authors： Kramer C,Mochalski P,Unterkofler K,Agapiou A,Ruzsanyi V,Liedl KR

更新日期：2016-01-27 00:00:00

abstract：:Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...

journal_title：Journal of breath research

authors： Harshman SW,Mani N,Geier BA,Kwak J,Shepard P,Fan M,Sudberry GL,Mayes RS,Ott DK,Martin JA,Grigsby CC

更新日期：2016-10-12 00:00:00

abstract：:Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FE(NO)) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared enviro...

journal_title：Journal of breath research

authors： Tarnoki DL,Tarnoki AD,Medda E,Littvay L,Lazar Z,Toccaceli V,Fagnani C,Stazi MA,Nisticó L,Brescianini S,Penna L,Lucatelli P,Boatta E,Zini C,Fanelli F,Baracchini C,Meneghetti G,Koller A,Osztovits J,Jermendy G,Preda

更新日期：2013-06-01 00:00:00

abstract：:Breath analysis techniques offer a potential revolution in health care diagnostics, especially if these techniques can be brought into standard use in the clinic and at home. The advent of microsensors combined with smart sensor system technology enables a new generation of sensor systems with significantly enhanced c...

journal_title：Journal of breath research

authors： Hunter GW,Xu JC,Biaggi-Labiosa AM,Laskowski D,Dutta PK,Mondal SP,Ward BJ,Makel DB,Liu CC,Chang CW,Dweik RA

更新日期：2011-09-01 00:00:00

abstract：:Sugar malabsorption in the bowel can lead to bloating, cramps, diarrhea and other symptoms of irritable bowel syndrome as well as affecting absorption of other nutrients. The hydrogen breath test is now a well established noninvasive test for assessing malabsorption of sugars in the small intestine. However, there are...

journal_title：Journal of breath research

authors： de Lacy Costello BP,Ledochowski M,Ratcliffe NM

更新日期：2013-06-01 00:00:00

abstract：:Exhaled NO (FE(NO)) measurements have been utilized as a marker to diagnose asthma as well as a non-invasive tool for monitoring airway inflammation and the response to anti-inflammatory medications. One area where this non-invasive monitoring may be helpful is for asthmatic athletes as they train for competitive even...

journal_title：Journal of breath research

authors： Grob NM,Laskowski D,Dweik RA

更新日期：2008-09-01 00:00:00